| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | PIK3R1 | Tyr688 | FAEPYNLySSLKELV | phosphorylation down-regulates activity | 9461588 | SIGNOR-251383 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | PIK3R1 PTyr688 | phosphorylation down-regulates ⊣ | PIK3R1 | 9461588 | SIGNOR-251383 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → down-regulates activity | PIK3R1 | SIGNOR-251383 |