| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2G | CHAT | Thr574 | VDNIRSAtPEALAFV | phosphorylation up-regulates activity | 12486117 | SIGNOR-250693 |
| PRKCB | CHAT | Thr373 | TVLVKDStNRDSLDM | phosphorylation up-regulates | 15381704 | SIGNOR-129296 |
| PRKCG | CHAT | Ser558 | VPTYESAsIRRFQEG | phosphorylation up-regulates | 15381704 | SIGNOR-129324 |
| PRKCA | CHAT | Thr373 | TVLVKDStNRDSLDM | phosphorylation up-regulates | 15381704 | SIGNOR-129276 |
| PRKCB | CHAT | Thr373 | TVLVKDStNRDSLDM | phosphorylation up-regulates | 12486117 | SIGNOR-96632 |
| PRKCG | CHAT | Thr373 | TVLVKDStNRDSLDM | phosphorylation up-regulates | 15381704 | SIGNOR-129332 |
| PRKCG | CHAT | Ser594 | HKAAVPAsEKLLLLK | phosphorylation up-regulates | 15381704 | SIGNOR-129328 |
| PRKCG | CHAT | Ser464 | LLKHVTQsSRKLIRA | phosphorylation up-regulates | 15381704 | SIGNOR-129316 |
| PRKCA | CHAT | Ser464 | LLKHVTQsSRKLIRA | phosphorylation up-regulates | 15381704 | SIGNOR-129260 |
| PRKCZ | CHAT | Ser594 | HKAAVPAsEKLLLLK | phosphorylation up-regulates | 15381704 | SIGNOR-129340 |
| PRKCE | CHAT | Ser558 | VPTYESAsIRRFQEG | phosphorylation up-regulates | 15381704 | SIGNOR-129308 |
| CAMK2A | CHAT | Thr574 | VDNIRSAtPEALAFV | phosphorylation up-regulates | 12486117 | SIGNOR-96628 |
| PRKCG | CHAT | Ser465 | LKHVTQSsRKLIRAD | phosphorylation up-regulates | 15381704 | SIGNOR-129320 |
| PRKCB | CHAT | Ser464 | LLKHVTQsSRKLIRA | phosphorylation up-regulates | 15381704 | SIGNOR-129280 |
| PRKCZ | CHAT | Ser558 | VPTYESAsIRRFQEG | phosphorylation up-regulates | 15381704 | SIGNOR-129336 |
| PRKCB | CHAT | Ser465 | LKHVTQSsRKLIRAD | phosphorylation up-regulates | 15381704 | SIGNOR-129284 |
| PRKCB | CHAT | Ser594 | HKAAVPAsEKLLLLK | phosphorylation up-regulates | 15381704 | SIGNOR-129292 |
| PRKCD | CHAT | Ser558 | VPTYESAsIRRFQEG | phosphorylation up-regulates quantity | 15381704 | SIGNOR-249271 |
| PRKCB | CHAT | Ser558 | VPTYESAsIRRFQEG | phosphorylation up-regulates | 15381704 | SIGNOR-129288 |
| PRKCE | CHAT | Ser594 | HKAAVPAsEKLLLLK | phosphorylation up-regulates | 15381704 | SIGNOR-129312 |
| PRKCA | CHAT | Ser558 | VPTYESAsIRRFQEG | phosphorylation up-regulates | 15381704 | SIGNOR-129268 |
| PRKCE | CHAT | Ser465 | LKHVTQSsRKLIRAD | phosphorylation up-regulates | 15381704 | SIGNOR-129304 |
| PRKCA | CHAT | Ser465 | LKHVTQSsRKLIRAD | phosphorylation up-regulates | 15381704 | SIGNOR-129264 |
| PRKCA | CHAT | Ser594 | HKAAVPAsEKLLLLK | phosphorylation up-regulates | 15381704 | SIGNOR-129272 |
| PRKCE | CHAT | Ser464 | LLKHVTQsSRKLIRA | phosphorylation up-regulates | 15381704 | SIGNOR-129300 |
| PRKCD | CHAT | Ser594 | HKAAVPAsEKLLLLK | phosphorylation up-regulates quantity | 15381704 | SIGNOR-249272 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2G | phosphorylation up-regulates → | CHAT PThr574 | phosphorylation up-regulates → | CHAT | 12486117 | SIGNOR-250693 |
| PRKCB | phosphorylation up-regulates → | CHAT PThr373 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129296 |
| PRKCG | phosphorylation up-regulates → | CHAT PSer558 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129324 |
| PRKCA | phosphorylation up-regulates → | CHAT PThr373 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129276 |
| PRKCB | phosphorylation up-regulates → | CHAT PThr373 | phosphorylation up-regulates → | CHAT | 12486117 | SIGNOR-96632 |
| PRKCG | phosphorylation up-regulates → | CHAT PThr373 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129332 |
| PRKCG | phosphorylation up-regulates → | CHAT PSer594 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129328 |
| PRKCG | phosphorylation up-regulates → | CHAT PSer464 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129316 |
| PRKCA | phosphorylation up-regulates → | CHAT PSer464 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129260 |
| PRKCZ | phosphorylation up-regulates → | CHAT PSer594 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129340 |
| PRKCE | phosphorylation up-regulates → | CHAT PSer558 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129308 |
| CAMK2A | phosphorylation up-regulates → | CHAT PThr574 | phosphorylation up-regulates → | CHAT | 12486117 | SIGNOR-96628 |
| PRKCG | phosphorylation up-regulates → | CHAT PSer465 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129320 |
| PRKCB | phosphorylation up-regulates → | CHAT PSer464 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129280 |
| PRKCZ | phosphorylation up-regulates → | CHAT PSer558 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129336 |
| PRKCB | phosphorylation up-regulates → | CHAT PSer465 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129284 |
| PRKCB | phosphorylation up-regulates → | CHAT PSer594 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129292 |
| PRKCD | phosphorylation up-regulates → | CHAT PSer558 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-249271 |
| PRKCB | phosphorylation up-regulates → | CHAT PSer558 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129288 |
| PRKCE | phosphorylation up-regulates → | CHAT PSer594 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129312 |
| PRKCA | phosphorylation up-regulates → | CHAT PSer558 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129268 |
| PRKCE | phosphorylation up-regulates → | CHAT PSer465 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129304 |
| PRKCA | phosphorylation up-regulates → | CHAT PSer465 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129264 |
| PRKCA | phosphorylation up-regulates → | CHAT PSer594 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129272 |
| PRKCE | phosphorylation up-regulates → | CHAT PSer464 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-129300 |
| PRKCD | phosphorylation up-regulates → | CHAT PSer594 | phosphorylation up-regulates → | CHAT | 15381704 | SIGNOR-249272 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2G | phosphorylation → up-regulates activity | CHAT | SIGNOR-250693 |
| PRKCB | phosphorylation → up-regulates | CHAT | SIGNOR-129296 |
| PRKCG | phosphorylation → up-regulates | CHAT | SIGNOR-129324 |
| PRKCA | phosphorylation → up-regulates | CHAT | SIGNOR-129276 |
| PRKCB | phosphorylation → up-regulates | CHAT | SIGNOR-96632 |
| PRKCG | phosphorylation → up-regulates | CHAT | SIGNOR-129332 |
| PRKCG | phosphorylation → up-regulates | CHAT | SIGNOR-129328 |
| PRKCG | phosphorylation → up-regulates | CHAT | SIGNOR-129316 |
| PRKCA | phosphorylation → up-regulates | CHAT | SIGNOR-129260 |
| PRKCZ | phosphorylation → up-regulates | CHAT | SIGNOR-129340 |
| PRKCE | phosphorylation → up-regulates | CHAT | SIGNOR-129308 |
| CAMK2A | phosphorylation → up-regulates | CHAT | SIGNOR-96628 |
| PRKCG | phosphorylation → up-regulates | CHAT | SIGNOR-129320 |
| PRKCB | phosphorylation → up-regulates | CHAT | SIGNOR-129280 |
| PRKCZ | phosphorylation → up-regulates | CHAT | SIGNOR-129336 |
| PRKCB | phosphorylation → up-regulates | CHAT | SIGNOR-129284 |
| PRKCB | phosphorylation → up-regulates | CHAT | SIGNOR-129292 |
| PRKCD | phosphorylation → up-regulates quantity | CHAT | SIGNOR-249271 |
| PRKCB | phosphorylation → up-regulates | CHAT | SIGNOR-129288 |
| PRKCE | phosphorylation → up-regulates | CHAT | SIGNOR-129312 |
| PRKCA | phosphorylation → up-regulates | CHAT | SIGNOR-129268 |
| PRKCE | phosphorylation → up-regulates | CHAT | SIGNOR-129304 |
| PRKCA | phosphorylation → up-regulates | CHAT | SIGNOR-129264 |
| PRKCA | phosphorylation → up-regulates | CHAT | SIGNOR-129272 |
| PRKCE | phosphorylation → up-regulates | CHAT | SIGNOR-129300 |
| PRKCD | phosphorylation → up-regulates quantity | CHAT | SIGNOR-249272 |
