| Name | DUSP1 |
| ID | P28562 |
| Role | phosphatase |
| Enzymatic Domains |
Rhodanese 20-137 PROSITE-ProRule
Tyrosine-protein phosphatase 173-314 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP1 | JUN | – | dephosphorylation down-regulates activity | 26734995 | SIGNOR-277102 | |
| DUSP1 | MAPK3 | – | dephosphorylation down-regulates | 10617468 | SIGNOR-73617 | |
| DUSP1 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248462 |
| DUSP1 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248463 |
| DUSP1 | MAPK1 | – | dephosphorylation down-regulates | 10617468 | SIGNOR-73614 | |
| DUSP1 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248464 |
| DUSP1 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248465 |
| DUSP1 | MAPK8 | – | dephosphorylation down-regulates | 9020184 | SIGNOR-46079 | |
| DUSP1 | MAPK9 | – | dephosphorylation down-regulates | 8626452 | SIGNOR-40879 | |
| DUSP1 | RUNX2 | Ser118 | AELVRTDsPNFLCSV | dephosphorylation up-regulates activity | 27031422 | SIGNOR-277143 |
| DUSP1 | MAPK14 | – | dephosphorylation down-regulates activity | 12356755 | SIGNOR-93873 | |
| DUSP1 | MAPK14 | – | dephosphorylation down-regulates activity | 17158101 | SIGNOR-236867 | |
| DUSP1 | MAPK14 | – | dephosphorylation down-regulates activity | 20626350 | SIGNOR-166571 | |
| DUSP1 | ERK1/2 | – | dephosphorylation down-regulates | 10617468 | SIGNOR-269930 | |
| DUSP1 | Gbeta | – | dephosphorylation down-regulates | 10617468 | SIGNOR-269910 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK3 PThr202 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248462 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248463 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248464 |
| DUSP1 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248465 |
| DUSP1 | dephosphorylation down-regulates ⊣ | RUNX2 PSer118 | dephosphorylation down-regulates ⊣ | RUNX2 | 27031422 | SIGNOR-277143 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DUSP1 | dephosphorylation → down-regulates activity | JUN | SIGNOR-277102 |
| DUSP1 | dephosphorylation down-regulates | MAPK3 | SIGNOR-73617 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248462 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248463 |
| DUSP1 | dephosphorylation down-regulates | MAPK1 | SIGNOR-73614 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248464 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248465 |
| DUSP1 | dephosphorylation down-regulates | MAPK8 | SIGNOR-46079 |
| DUSP1 | dephosphorylation down-regulates | MAPK9 | SIGNOR-40879 |
| DUSP1 | dephosphorylation → up-regulates activity | RUNX2 | SIGNOR-277143 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-93873 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-236867 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-166571 |
| DUSP1 | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269930 |
| DUSP1 | dephosphorylation down-regulates | Gbeta | SIGNOR-269910 |