Summary

Name DUSP1
Full Name Dual specificity protein phosphatase 1
Synonyms Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1, MAP kinase phosphatase 1, MKP-1, Protein-tyrosine phosphatase CL100 | CL100, MKP1, PTPN10, VH1
Primary ID P28562
Links - -
Type protein
Relations 24
Pathways NOTCH Signaling and Myogenesis
Function Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png acetylation DUSP1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DUSP1 0.31
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DUSP1 0.35
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DUSP1 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DUSP1 0.35
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.43
Publications: 2 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.4
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates quantity img/direct-activation.png DUSP1 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14 0.31
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:NOTCH Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.43
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK8 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DUSP1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding DUSP1 0.35
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation DUSP1 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:NOTCH Signaling and Myogenesis