| Name | DUSP1 |
| ID | P28562 |
| Role | substrate |
| Enzymatic Domains |
Rhodanese 20-137 PROSITE-ProRule
Tyrosine-protein phosphatase 173-314 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | DUSP1 | Ser323 | HCSAEAGsPAMAVLD | phosphorylation down-regulates | 16286470 | SIGNOR-141609 |
| MAPK1 | DUSP1 | Ser364 | LQSPITTsPSC | phosphorylation up-regulates | 10617468 | SIGNOR-73625 |
| MAPK1 | DUSP1 | Ser296 | KQRRSIIsPNFSFMG | phosphorylation down-regulates | 16286470 | SIGNOR-141593 |
| MAPK1 | DUSP1 | Ser359 | SALSYLQsPITTSPS | phosphorylation up-regulates | 10617468 | SIGNOR-73621 |
| PRKAA2 | DUSP1 | Ser334 | AVLDRGTsTTTVFNF | phosphorylation down-regulates quantity by destabilization | 25799226 | SIGNOR-276890 |
| MAPK1 | DUSP1 | Ser323 | HCSAEAGsPAMAVLD | phosphorylation down-regulates | 16286470 | SIGNOR-141601 |
| MAPK3 | DUSP1 | Ser296 | KQRRSIIsPNFSFMG | phosphorylation down-regulates | 16286470 | SIGNOR-141605 |
| MAPK3 | DUSP1 | Ser359 | SALSYLQsPITTSPS | phosphorylation up-regulates | 10617468 | SIGNOR-73629 |
| Gbeta | DUSP1 | – | phosphorylation down-regulates | 16286470 | SIGNOR-270093 | |
| MAPK3 | DUSP1 | Ser364 | LQSPITTsPSC | phosphorylation up-regulates | 10617468 | SIGNOR-73633 |
| ERK1/2 | DUSP1 | – | phosphorylation down-regulates | 16286470 | SIGNOR-270189 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | DUSP1 PSer323 | phosphorylation down-regulates ⊣ | DUSP1 | 16286470 | SIGNOR-141609 |
| MAPK1 | phosphorylation up-regulates → | DUSP1 PSer364 | phosphorylation up-regulates → | DUSP1 | 10617468 | SIGNOR-73625 |
| MAPK1 | phosphorylation up-regulates → | DUSP1 PSer296 | phosphorylation down-regulates ⊣ | DUSP1 | 16286470 | SIGNOR-141593 |
| MAPK1 | phosphorylation up-regulates → | DUSP1 PSer359 | phosphorylation up-regulates → | DUSP1 | 10617468 | SIGNOR-73621 |
| PRKAA2 | phosphorylation up-regulates → | DUSP1 PSer334 | phosphorylation down-regulates ⊣ | DUSP1 | 25799226 | SIGNOR-276890 |
| MAPK1 | phosphorylation up-regulates → | DUSP1 PSer323 | phosphorylation down-regulates ⊣ | DUSP1 | 16286470 | SIGNOR-141601 |
| MAPK3 | phosphorylation up-regulates → | DUSP1 PSer296 | phosphorylation down-regulates ⊣ | DUSP1 | 16286470 | SIGNOR-141605 |
| MAPK3 | phosphorylation up-regulates → | DUSP1 PSer359 | phosphorylation up-regulates → | DUSP1 | 10617468 | SIGNOR-73629 |
| MAPK3 | phosphorylation up-regulates → | DUSP1 PSer364 | phosphorylation up-regulates → | DUSP1 | 10617468 | SIGNOR-73633 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation down-regulates | DUSP1 | SIGNOR-141609 |
| MAPK1 | phosphorylation → up-regulates | DUSP1 | SIGNOR-73625 |
| MAPK1 | phosphorylation down-regulates | DUSP1 | SIGNOR-141593 |
| MAPK1 | phosphorylation → up-regulates | DUSP1 | SIGNOR-73621 |
| PRKAA2 | phosphorylation down-regulates quantity by destabilization | DUSP1 | SIGNOR-276890 |
| MAPK1 | phosphorylation down-regulates | DUSP1 | SIGNOR-141601 |
| MAPK3 | phosphorylation down-regulates | DUSP1 | SIGNOR-141605 |
| MAPK3 | phosphorylation → up-regulates | DUSP1 | SIGNOR-73629 |
| Gbeta | phosphorylation down-regulates | DUSP1 | SIGNOR-270093 |
| MAPK3 | phosphorylation → up-regulates | DUSP1 | SIGNOR-73633 |
| ERK1/2 | phosphorylation down-regulates | DUSP1 | SIGNOR-270189 |