| Name | SHC1 |
| ID | P29353 |
| Role | substrate |
| Enzymatic Domains |
PID 156-339 PROSITE-ProRule
SH2 488-579 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | dephosphorylation down-regulates activity | 9488479 | SIGNOR-248397 |
| LTK | SHC1 | – | phosphorylation up-regulates | 9223670 | SIGNOR-49625 | |
| PTPN12 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | dephosphorylation down-regulates | 8939605 | SIGNOR-44361 |
| SYK | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates | 9710204 | SIGNOR-59635 |
| SRC | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates activity | 8939605 | SIGNOR-44866 |
| FLT4 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation unknown | 9927207 | SIGNOR-64186 |
| FLT4 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation unknown | 9927207 | SIGNOR-64190 |
| PTPRG | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254723 |
| PRKCE | SHC1 | Ser139 | EEWTRHGsFVNKPTR | phosphorylation up-regulates activity | 12052829 | SIGNOR-263048 |
| LCK | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 9710204 | SIGNOR-251388 |
| PTPN12 | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | dephosphorylation down-regulates | 8939605 | SIGNOR-44862 |
| TGFBR1 | SHC1 | – | phosphorylation up-regulates | 17673906 | SIGNOR-227503 | |
| SYK | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | phosphorylation up-regulates | 9710204 | SIGNOR-59639 |
| ALK | SHC1 | – | phosphorylation up-regulates | 12185581 | SIGNOR-91534 | |
| INSR | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 11075717 | SIGNOR-251325 |
| ZAP70 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates | 9710204 | SIGNOR-59659 |
| FLT3 | SHC1 | – | phosphorylation up-regulates activity | 15769897 | SIGNOR-261540 | |
| SYK | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates | 9710204 | SIGNOR-59643 |
| FYN | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates | 9710204 | SIGNOR-59631 |
| PTPRG | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254724 |
| PRKCD | SHC1 | Ser28 | LEEGASGsTPPEELP | phosphorylation unknown | 16963224 | SIGNOR-149402 |
| PTK2 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 9566877 | SIGNOR-259854 |
| FYN | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | phosphorylation up-regulates | 9710204 | SIGNOR-59627 |
| FLT4 | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | phosphorylation unknown | 9927207 | SIGNOR-64076 |
| SRC | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | phosphorylation up-regulates activity | 8939605 | SIGNOR-44870 |
| ZAP70 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates | 9710204 | SIGNOR-59647 |
| PRKCD | SHC1 | Ser139 | EEWTRHGsFVNKPTR | phosphorylation up-regulates | 16963224 | SIGNOR-149398 |
| PRKCA | SHC1 | Ser139 | EEWTRHGsFVNKPTR | phosphorylation up-regulates activity | 12052829 | SIGNOR-249150 |
| PDGFRB | SHC1 | – | phosphorylation up-regulates | 8195171 | SIGNOR-36906 | |
| PRKCA | SHC1 | Ser139 | EEWTRHGsFVNKPTR | phosphorylation up-regulates activity | 12052829 | SIGNOR-263047 |
| FLT3 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 10482988 | SIGNOR-251148 |
| FLT3 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates activity | 10482988 | SIGNOR-251146 |
| FYN | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates | 9710204 | SIGNOR-59623 |
| ZAP70 | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | phosphorylation up-regulates | 9710204 | SIGNOR-59651 |
| FYN | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates | 9741627 | SIGNOR-60160 |
| FLT3 | SHC1 | Tyr350 | EPPDHQYyNDFPGKE | phosphorylation up-regulates activity | 10482988 | SIGNOR-251147 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | dephosphorylation down-regulates ⊣ | SHC1 PTyr349 | dephosphorylation up-regulates → | SHC1 | 9488479 | SIGNOR-248397 |
| PTPN12 | dephosphorylation down-regulates ⊣ | SHC1 PTyr349 | dephosphorylation up-regulates → | SHC1 | 8939605 | SIGNOR-44361 |
| SYK | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59635 |
| SRC | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 8939605 | SIGNOR-44866 |
| FLT4 | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation down-regulates ⊣ | SHC1 | 9927207 | SIGNOR-64186 |
| FLT4 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation down-regulates ⊣ | SHC1 | 9927207 | SIGNOR-64190 |
| PTPRG | dephosphorylation down-regulates ⊣ | SHC1 PTyr349 | dephosphorylation up-regulates → | SHC1 | 25624455 | SIGNOR-254723 |
| PRKCE | phosphorylation up-regulates → | SHC1 PSer139 | phosphorylation up-regulates → | SHC1 | 12052829 | SIGNOR-263048 |
| LCK | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-251388 |
| PTPN12 | dephosphorylation down-regulates ⊣ | SHC1 PTyr350 | dephosphorylation up-regulates → | SHC1 | 8939605 | SIGNOR-44862 |
| SYK | phosphorylation up-regulates → | SHC1 PTyr350 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59639 |
| INSR | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 11075717 | SIGNOR-251325 |
| ZAP70 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59659 |
| SYK | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59643 |
| FYN | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59631 |
| PTPRG | dephosphorylation down-regulates ⊣ | SHC1 PTyr350 | dephosphorylation up-regulates → | SHC1 | 25624455 | SIGNOR-254724 |
| PRKCD | phosphorylation up-regulates → | SHC1 PSer28 | phosphorylation down-regulates ⊣ | SHC1 | 16963224 | SIGNOR-149402 |
| PTK2 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9566877 | SIGNOR-259854 |
| FYN | phosphorylation up-regulates → | SHC1 PTyr350 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59627 |
| FLT4 | phosphorylation up-regulates → | SHC1 PTyr350 | phosphorylation down-regulates ⊣ | SHC1 | 9927207 | SIGNOR-64076 |
| SRC | phosphorylation up-regulates → | SHC1 PTyr350 | phosphorylation up-regulates → | SHC1 | 8939605 | SIGNOR-44870 |
| ZAP70 | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59647 |
| PRKCD | phosphorylation up-regulates → | SHC1 PSer139 | phosphorylation up-regulates → | SHC1 | 16963224 | SIGNOR-149398 |
| PRKCA | phosphorylation up-regulates → | SHC1 PSer139 | phosphorylation up-regulates → | SHC1 | 12052829 | SIGNOR-249150 |
| PRKCA | phosphorylation up-regulates → | SHC1 PSer139 | phosphorylation up-regulates → | SHC1 | 12052829 | SIGNOR-263047 |
| FLT3 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 10482988 | SIGNOR-251148 |
| FLT3 | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 10482988 | SIGNOR-251146 |
| FYN | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59623 |
| ZAP70 | phosphorylation up-regulates → | SHC1 PTyr350 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59651 |
| FYN | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9741627 | SIGNOR-60160 |
| FLT3 | phosphorylation up-regulates → | SHC1 PTyr350 | phosphorylation up-regulates → | SHC1 | 10482988 | SIGNOR-251147 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN2 | dephosphorylation → down-regulates activity | SHC1 | SIGNOR-248397 |
| LTK | phosphorylation → up-regulates | SHC1 | SIGNOR-49625 |
| PTPN12 | dephosphorylation down-regulates | SHC1 | SIGNOR-44361 |
| SYK | phosphorylation → up-regulates | SHC1 | SIGNOR-59635 |
| SRC | phosphorylation → up-regulates activity | SHC1 | SIGNOR-44866 |
| FLT4 | phosphorylation → unknown | SHC1 | SIGNOR-64186 |
| FLT4 | phosphorylation → unknown | SHC1 | SIGNOR-64190 |
| PTPRG | dephosphorylation → down-regulates activity | SHC1 | SIGNOR-254723 |
| PRKCE | phosphorylation → up-regulates activity | SHC1 | SIGNOR-263048 |
| LCK | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251388 |
| PTPN12 | dephosphorylation down-regulates | SHC1 | SIGNOR-44862 |
| TGFBR1 | phosphorylation → up-regulates | SHC1 | SIGNOR-227503 |
| SYK | phosphorylation → up-regulates | SHC1 | SIGNOR-59639 |
| ALK | phosphorylation → up-regulates | SHC1 | SIGNOR-91534 |
| INSR | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251325 |
| ZAP70 | phosphorylation → up-regulates | SHC1 | SIGNOR-59659 |
| FLT3 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-261540 |
| SYK | phosphorylation → up-regulates | SHC1 | SIGNOR-59643 |
| FYN | phosphorylation → up-regulates | SHC1 | SIGNOR-59631 |
| PTPRG | dephosphorylation → down-regulates activity | SHC1 | SIGNOR-254724 |
| PRKCD | phosphorylation → unknown | SHC1 | SIGNOR-149402 |
| PTK2 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-259854 |
| FYN | phosphorylation → up-regulates | SHC1 | SIGNOR-59627 |
| FLT4 | phosphorylation → unknown | SHC1 | SIGNOR-64076 |
| SRC | phosphorylation → up-regulates activity | SHC1 | SIGNOR-44870 |
| ZAP70 | phosphorylation → up-regulates | SHC1 | SIGNOR-59647 |
| PRKCD | phosphorylation → up-regulates | SHC1 | SIGNOR-149398 |
| PRKCA | phosphorylation → up-regulates activity | SHC1 | SIGNOR-249150 |
| PDGFRB | phosphorylation → up-regulates | SHC1 | SIGNOR-36906 |
| PRKCA | phosphorylation → up-regulates activity | SHC1 | SIGNOR-263047 |
| FLT3 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251148 |
| FLT3 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251146 |
| FYN | phosphorylation → up-regulates | SHC1 | SIGNOR-59623 |
| ZAP70 | phosphorylation → up-regulates | SHC1 | SIGNOR-59651 |
| FYN | phosphorylation → up-regulates | SHC1 | SIGNOR-60160 |
| FLT3 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251147 |