Summary

Name SHC1
Full Name SHC-transforming protein 1
Synonyms SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1 | SHC, SHCA
Primary ID P29353
Links - -
Type protein
Relations 57
Pathways EGFR, IL6 , Noonan syndrome, Thyroid cancer, miRNA in AML
Function Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation SHC1 0.36
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.22
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SHC1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.14
Publications: 3 Organism: Homo Sapiens
Pathways:miRNA in AML
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.28
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.31
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SHC1 0.36
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SHC1 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SHC1 0.14
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation SHC1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.38
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.36
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR, IL6
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.14
Publications: 1
+ up-regulates activity img/indirect-activation.png MAPK1 0.28
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png MAPK3 0.22
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png SHC1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png binding SHC1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding INPP5D 0.31
Publications: 1 Organism: Homo Sapiens
Pathways:miRNA in AML
+ up-regulates img/direct-activation.png binding SHC1 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SHC1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SHC1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png binding SHC1 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRAP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.73
Publications: 1 Organism: Mus Musculus
Pathways:EGFR, Noonan syndrome
+ up-regulates activity img/direct-activation.png binding SHC1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png binding SOS1 0.55
Publications: 1 Organism: Mus Musculus
Pathways:EGFR, IL6 , Noonan syndrome, Thyroid cancer
+ up-regulates img/direct-activation.png binding GRB2 0.91
Publications: 4 Organism: Sus Scrofa, Homo Sapiens, Mus Musculus
Pathways:EGFR, IL6 , Noonan syndrome, Thyroid cancer
+ up-regulates img/direct-activation.png binding SHC1 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SHC1 0.73
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Noonan syndrome
+ up-regulates img/direct-activation.png binding SHC1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:IL6
+ up-regulates img/direct-activation.png binding SHC1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png binding SHC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid cancer
+ up-regulates activity img/indirect-activation.png ERK1/2 0.14
Publications: 1 Organism: Mus Musculus
Pathways:EGFR, IL6 , Noonan syndrome, Thyroid cancer