| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 9566877 | SIGNOR-259854 |
| FLT3 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 10482988 | SIGNOR-251148 |
| FYN | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates | 9741627 | SIGNOR-60160 |
| FLT4 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation unknown | 9927207 | SIGNOR-64190 |
| LCK | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 9710204 | SIGNOR-251388 |
| INSR | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 11075717 | SIGNOR-251325 |
| ZAP70 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates | 9710204 | SIGNOR-59659 |
| SYK | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates | 9710204 | SIGNOR-59643 |
| FYN | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates | 9710204 | SIGNOR-59631 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9566877 | SIGNOR-259854 |
| FLT3 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 10482988 | SIGNOR-251148 |
| FYN | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9741627 | SIGNOR-60160 |
| FLT4 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation down-regulates ⊣ | SHC1 | 9927207 | SIGNOR-64190 |
| LCK | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-251388 |
| INSR | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 11075717 | SIGNOR-251325 |
| ZAP70 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59659 |
| SYK | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59643 |
| FYN | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59631 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK2 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-259854 |
| FLT3 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251148 |
| FYN | phosphorylation → up-regulates | SHC1 | SIGNOR-60160 |
| FLT4 | phosphorylation → unknown | SHC1 | SIGNOR-64190 |
| LCK | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251388 |
| INSR | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251325 |
| ZAP70 | phosphorylation → up-regulates | SHC1 | SIGNOR-59659 |
| SYK | phosphorylation → up-regulates | SHC1 | SIGNOR-59643 |
| FYN | phosphorylation → up-regulates | SHC1 | SIGNOR-59631 |
