| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | dephosphorylation down-regulates activity | 9488479 | SIGNOR-248397 |
| FYN | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates | 9710204 | SIGNOR-59623 |
| SRC | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates activity | 8939605 | SIGNOR-44866 |
| SYK | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates | 9710204 | SIGNOR-59635 |
| FLT4 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation unknown | 9927207 | SIGNOR-64186 |
| PTPN12 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | dephosphorylation down-regulates | 8939605 | SIGNOR-44361 |
| FLT3 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates activity | 10482988 | SIGNOR-251146 |
| PTPRG | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254723 |
| ZAP70 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | phosphorylation up-regulates | 9710204 | SIGNOR-59647 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | dephosphorylation down-regulates ⊣ | SHC1 PTyr349 | dephosphorylation up-regulates → | SHC1 | 9488479 | SIGNOR-248397 |
| FYN | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59623 |
| SRC | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 8939605 | SIGNOR-44866 |
| SYK | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59635 |
| FLT4 | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation down-regulates ⊣ | SHC1 | 9927207 | SIGNOR-64186 |
| PTPN12 | dephosphorylation down-regulates ⊣ | SHC1 PTyr349 | dephosphorylation up-regulates → | SHC1 | 8939605 | SIGNOR-44361 |
| FLT3 | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 10482988 | SIGNOR-251146 |
| PTPRG | dephosphorylation down-regulates ⊣ | SHC1 PTyr349 | dephosphorylation up-regulates → | SHC1 | 25624455 | SIGNOR-254723 |
| ZAP70 | phosphorylation up-regulates → | SHC1 PTyr349 | phosphorylation up-regulates → | SHC1 | 9710204 | SIGNOR-59647 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN2 | dephosphorylation → down-regulates activity | SHC1 | SIGNOR-248397 |
| FYN | phosphorylation → up-regulates | SHC1 | SIGNOR-59623 |
| SRC | phosphorylation → up-regulates activity | SHC1 | SIGNOR-44866 |
| SYK | phosphorylation → up-regulates | SHC1 | SIGNOR-59635 |
| FLT4 | phosphorylation → unknown | SHC1 | SIGNOR-64186 |
| PTPN12 | dephosphorylation down-regulates | SHC1 | SIGNOR-44361 |
| FLT3 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251146 |
| PTPRG | dephosphorylation → down-regulates activity | SHC1 | SIGNOR-254723 |
| ZAP70 | phosphorylation → up-regulates | SHC1 | SIGNOR-59647 |
