| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | PML | Thr28 | PTMPPPEtPSEGRQP | phosphorylation up-regulates | 15093545 | SIGNOR-124313 |
| HIPK2 | PML | Ser38 | EGRQPSPsPSPTERA | phosphorylation up-regulates | 19015637 | SIGNOR-182428 |
| MAPK1 | PML | Ser38 | EGRQPSPsPSPTERA | phosphorylation up-regulates | 15093545 | SIGNOR-124244 |
| CSNK2A1 | PML | Ser565 | VISSSEDsDAENSSS | phosphorylation down-regulates | 16873060 | SIGNOR-148310 |
| MAPK7 | PML | – | phosphorylation down-regulates | 20832753 | SIGNOR-167947 | |
| MAPK7 | PML | Thr409 | ASPEAAStPRDPIDV | phosphorylation down-regulates activity | 23730625 | SIGNOR-279074 |
| MAPK7 | PML | Ser403 | AAVSKKAsPEAASTP | phosphorylation down-regulates activity | 23730625 | SIGNOR-279075 |
| Gbeta | PML | – | phosphorylation up-regulates | 15093545 | SIGNOR-270034 | |
| MAPK1 | PML | Ser527 | PHLDGPPsPRSPVIG | phosphorylation up-regulates | 15093545 | SIGNOR-124252 |
| MAPK1 | PML | Ser40 | RQPSPSPsPTERAPA | phosphorylation up-regulates | 15093545 | SIGNOR-124248 |
| HIPK2 | PML | Ser8 | MEPAPARsPRPQQDP | phosphorylation up-regulates | 19015637 | SIGNOR-182432 |
| MAPK1 | PML | Ser530 | DGPPSPRsPVIGSEV | phosphorylation up-regulates | 15093545 | SIGNOR-124056 |
| MAPK1 | PML | Ser36 | PSEGRQPsPSPSPTE | phosphorylation up-regulates | 15093545 | SIGNOR-124240 |
| CHEK2 | PML | Ser117 | ESLQRRLsVYRQIVD | phosphorylation unknown | 12402044 | SIGNOR-94872 |
| CSNK2A1 | PML | Ser518 | PSTSKAVsPPHLDGP | phosphorylation down-regulates | 16873060 | SIGNOR-148306 |
| MAPK3 | PML | Ser530 | DGPPSPRsPVIGSEV | phosphorylation up-regulates | 15093545 | SIGNOR-124317 |
| ERK1/2 | PML | – | phosphorylation up-regulates | 15093545 | SIGNOR-270153 | |
| CDK1 | PML | – | phosphorylation down-regulates | 21840486 | SIGNOR-176033 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | PML PThr28 | phosphorylation up-regulates → | PML | 15093545 | SIGNOR-124313 |
| HIPK2 | phosphorylation up-regulates → | PML PSer38 | phosphorylation up-regulates → | PML | 19015637 | SIGNOR-182428 |
| MAPK1 | phosphorylation up-regulates → | PML PSer38 | phosphorylation up-regulates → | PML | 15093545 | SIGNOR-124244 |
| CSNK2A1 | phosphorylation up-regulates → | PML PSer565 | phosphorylation down-regulates ⊣ | PML | 16873060 | SIGNOR-148310 |
| MAPK7 | phosphorylation up-regulates → | PML PThr409 | phosphorylation down-regulates ⊣ | PML | 23730625 | SIGNOR-279074 |
| MAPK7 | phosphorylation up-regulates → | PML PSer403 | phosphorylation down-regulates ⊣ | PML | 23730625 | SIGNOR-279075 |
| MAPK1 | phosphorylation up-regulates → | PML PSer527 | phosphorylation up-regulates → | PML | 15093545 | SIGNOR-124252 |
| MAPK1 | phosphorylation up-regulates → | PML PSer40 | phosphorylation up-regulates → | PML | 15093545 | SIGNOR-124248 |
| HIPK2 | phosphorylation up-regulates → | PML PSer8 | phosphorylation up-regulates → | PML | 19015637 | SIGNOR-182432 |
| MAPK1 | phosphorylation up-regulates → | PML PSer530 | phosphorylation up-regulates → | PML | 15093545 | SIGNOR-124056 |
| MAPK1 | phosphorylation up-regulates → | PML PSer36 | phosphorylation up-regulates → | PML | 15093545 | SIGNOR-124240 |
| CHEK2 | phosphorylation up-regulates → | PML PSer117 | phosphorylation down-regulates ⊣ | PML | 12402044 | SIGNOR-94872 |
| CSNK2A1 | phosphorylation up-regulates → | PML PSer518 | phosphorylation down-regulates ⊣ | PML | 16873060 | SIGNOR-148306 |
| MAPK3 | phosphorylation up-regulates → | PML PSer530 | phosphorylation up-regulates → | PML | 15093545 | SIGNOR-124317 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates | PML | SIGNOR-124313 |
| HIPK2 | phosphorylation → up-regulates | PML | SIGNOR-182428 |
| MAPK1 | phosphorylation → up-regulates | PML | SIGNOR-124244 |
| CSNK2A1 | phosphorylation down-regulates | PML | SIGNOR-148310 |
| MAPK7 | phosphorylation down-regulates | PML | SIGNOR-167947 |
| MAPK7 | phosphorylation → down-regulates activity | PML | SIGNOR-279074 |
| MAPK7 | phosphorylation → down-regulates activity | PML | SIGNOR-279075 |
| Gbeta | phosphorylation → up-regulates | PML | SIGNOR-270034 |
| MAPK1 | phosphorylation → up-regulates | PML | SIGNOR-124252 |
| MAPK1 | phosphorylation → up-regulates | PML | SIGNOR-124248 |
| HIPK2 | phosphorylation → up-regulates | PML | SIGNOR-182432 |
| MAPK1 | phosphorylation → up-regulates | PML | SIGNOR-124056 |
| MAPK1 | phosphorylation → up-regulates | PML | SIGNOR-124240 |
| CHEK2 | phosphorylation → unknown | PML | SIGNOR-94872 |
| CSNK2A1 | phosphorylation down-regulates | PML | SIGNOR-148306 |
| MAPK3 | phosphorylation → up-regulates | PML | SIGNOR-124317 |
| ERK1/2 | phosphorylation → up-regulates | PML | SIGNOR-270153 |
| CDK1 | phosphorylation down-regulates | PML | SIGNOR-176033 |
