Summary

Name PML
Full Name Protein PML
Synonyms Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19 | MYL, PP8675, RNF71, TRIM19
Primary ID P29590
Links - -
Type protein
Relations 22
Function Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation PML 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PML 0.35
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PML 0.39
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PML 0.38
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PML 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding KAT6A/PML 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell death 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PML 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Apoptosis 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD3 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD3 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD2 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PML 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ZFYVE9 0.22
Publications: 1 Organism: Homo Sapiens