Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
HIPK2	PML	Ser8 View in OncoXplorer	MEPAPARsPRPQQDP	phosphorylation up-regulates	19015637	SIGNOR-182432

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
HIPK2	phosphorylation up-regulates →	PML PSer8	phosphorylation up-regulates →	PML	19015637	SIGNOR-182432

Regulator	Mechanism/Effect	Target	SIGNOR-ID
HIPK2	phosphorylation → up-regulates	PML	SIGNOR-182432