| Name | CDC25C |
| ID | P30307 |
| Role | phosphatase |
| Enzymatic Domains |
Rhodanese 321-428 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC25C | CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates | 19574738 | SIGNOR-186617 |
| CDC25C | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates | 19574738 | SIGNOR-186621 |
| CDC25C | CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates activity | 17634129 | SIGNOR-276945 |
| CDC25C | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates activity | 24643073 | SIGNOR-276944 |
| CDC25C | CCNB1 | – | dephosphorylation up-regulates activity | 25949173 | SIGNOR-277099 | |
| CDC25C | MAP3K5 | – | dephosphorylation down-regulates activity | 32518522 | SIGNOR-277100 | |
| CDC25C | CyclinB/CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates activity | 10913154 | SIGNOR-251509 |
| CDC25C | CyclinB/CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates activity | 10913154 | SIGNOR-255037 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CDK1 | 19574738 | SIGNOR-186617 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CDK1 | 19574738 | SIGNOR-186621 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CDK1 | 17634129 | SIGNOR-276945 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CDK1 | 24643073 | SIGNOR-276944 |
| CDC25C | dephosphorylation down-regulates ⊣ | CyclinB/CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CyclinB/CDK1 | 10913154 | SIGNOR-251509 |
| CDC25C | dephosphorylation down-regulates ⊣ | CyclinB/CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CyclinB/CDK1 | 10913154 | SIGNOR-255037 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC25C | dephosphorylation → up-regulates | CDK1 | SIGNOR-186617 |
| CDC25C | dephosphorylation → up-regulates | CDK1 | SIGNOR-186621 |
| CDC25C | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-276945 |
| CDC25C | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-276944 |
| CDC25C | dephosphorylation → up-regulates activity | CCNB1 | SIGNOR-277099 |
| CDC25C | dephosphorylation → down-regulates activity | MAP3K5 | SIGNOR-277100 |
| CDC25C | dephosphorylation → up-regulates activity | CyclinB/CDK1 | SIGNOR-251509 |
| CDC25C | dephosphorylation → up-regulates activity | CyclinB/CDK1 | SIGNOR-255037 |