| Name | CDC25C |
| ID | P30307 |
| Role | substrate |
| Enzymatic Domains |
Rhodanese 321-428 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | CDC25C | – | phosphorylation up-regulates activity | 10913154 | SIGNOR-251510 | |
| CHEK2 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 12835754 | SIGNOR-102779 |
| JNK | CDC25C | – | phosphorylation down-regulates | 20220133 | SIGNOR-269983 | |
| BRSK1 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 15150265 | SIGNOR-107408 |
| CyclinB/CDK1 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 10864927 | SIGNOR-216765 |
| MAPK9 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 20220133 | SIGNOR-164093 |
| CDK1 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 8119945 | SIGNOR-36267 |
| PKN1 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation unknown | 15791647 | SIGNOR-249277 |
| CDK2 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 20530684 | SIGNOR-165872 |
| ROBO | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates | 15150265 | SIGNOR-124851 |
| CyclinB/CDK1 | CDC25C | Ser122 | DQHLMKCsPAQLLCS | phosphorylation up-regulates | 10864927 | SIGNOR-216741 |
| CDK1 | CDC25C | Ser122 | DQHLMKCsPAQLLCS | phosphorylation up-regulates | 10864927 | SIGNOR-78416 |
| CyclinB/CDK1 | CDC25C | Thr67 | LSILSGGtPKRCLDL | phosphorylation up-regulates | 10864927 | SIGNOR-216777 |
| CDK1 | CDC25C | Thr67 | LSILSGGtPKRCLDL | phosphorylation up-regulates | 10037602 | SIGNOR-64968 |
| BRSK1 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates | 9543386 | SIGNOR-56473 |
| MARK3 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 9543386 | SIGNOR-250176 |
| SYK | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 25506060 | SIGNOR-278328 |
| CyclinB/CDK1 | CDC25C | Thr48 | VCPDVPRtPVGKFLG | phosphorylation up-regulates | 10864927 | SIGNOR-216773 |
| CDK1 | CDC25C | Thr67 | LSILSGGtPKRCLDL | phosphorylation up-regulates | 10864927 | SIGNOR-78432 |
| CDK1 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 10864927 | SIGNOR-78420 |
| CHEK1 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates quantity by destabilization | 20068082 | SIGNOR-163158 |
| CyclinE/CDK2 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 20530684 | SIGNOR-216721 |
| MAPK14 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 9543386 | SIGNOR-250091 |
| CSNK2A1 | CDC25C | Thr236 | VEKFKDNtIPDKVKK | phosphorylation down-regulates | 15064744 | SIGNOR-123713 |
| p38 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 11333986 | SIGNOR-107420 |
| PLK3 | CDC25C | Ser198 | SDELMEFsLKDQEAK | phosphorylation up-regulates | 14968113 | SIGNOR-122094 |
| CDK1 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 10037602 | SIGNOR-64972 |
| CDK1 | CDC25C | Thr48 | VCPDVPRtPVGKFLG | phosphorylation up-regulates | 8119945 | SIGNOR-36271 |
| CDK1 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 10037602 | SIGNOR-64960 |
| CDK1 | CDC25C | Thr130 | PAQLLCStPNGLDRG | phosphorylation up-regulates | 10864927 | SIGNOR-78424 |
| PIM1 | CDC25C | – | phosphorylation up-regulates activity | 16356754 | SIGNOR-278298 | |
| PLK3 | CDC25C | Ser191 | EDQAEEIsDELMEFS | phosphorylation up-regulates | 14968113 | SIGNOR-122090 |
| MAPK10 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 20220133 | SIGNOR-164085 |
| PLK1 | CDC25C | Ser198 | SDELMEFsLKDQEAK | phosphorylation up-regulates | 11897663 | SIGNOR-115993 |
| CDK1 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 8119945 | SIGNOR-36279 |
| CyclinB/CDK1 | CDC25C | Thr130 | PAQLLCStPNGLDRG | phosphorylation up-regulates | 10864927 | SIGNOR-216769 |
| CDK1 | CDC25C | Thr48 | VCPDVPRtPVGKFLG | phosphorylation up-regulates | 10864927 | SIGNOR-78428 |
| MAPK8 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 20220133 | SIGNOR-164089 |
| PLK4 | CDC25C | – | phosphorylation up-regulates quantity | 35912011 | SIGNOR-280074 | |
| CDK1 | CDC25C | Thr67 | LSILSGGtPKRCLDL | phosphorylation up-regulates | 8119945 | SIGNOR-36275 |
| ATR | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation up-regulates activity | 28264028 | SIGNOR-279008 |
| CDK1 | CDC25C | Thr48 | VCPDVPRtPVGKFLG | phosphorylation up-regulates | 10037602 | SIGNOR-64964 |
| PLK3 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation unknown | 10557092 | SIGNOR-249030 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 12835754 | SIGNOR-102779 |
| BRSK1 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 15150265 | SIGNOR-107408 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-216765 |
| MAPK9 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 20220133 | SIGNOR-164093 |
| CDK1 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 8119945 | SIGNOR-36267 |
| PKN1 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 15791647 | SIGNOR-249277 |
| CDK2 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 20530684 | SIGNOR-165872 |
| ROBO | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 15150265 | SIGNOR-124851 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CDC25C PSer122 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-216741 |
| CDK1 | phosphorylation up-regulates → | CDC25C PSer122 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-78416 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CDC25C PThr67 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-216777 |
| CDK1 | phosphorylation up-regulates → | CDC25C PThr67 | phosphorylation up-regulates → | CDC25C | 10037602 | SIGNOR-64968 |
| BRSK1 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 9543386 | SIGNOR-56473 |
| MARK3 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 9543386 | SIGNOR-250176 |
| SYK | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 25506060 | SIGNOR-278328 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CDC25C PThr48 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-216773 |
| CDK1 | phosphorylation up-regulates → | CDC25C PThr67 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-78432 |
| CDK1 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-78420 |
| CHEK1 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 20068082 | SIGNOR-163158 |
| CyclinE/CDK2 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 20530684 | SIGNOR-216721 |
| MAPK14 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 9543386 | SIGNOR-250091 |
| CSNK2A1 | phosphorylation up-regulates → | CDC25C PThr236 | phosphorylation down-regulates ⊣ | CDC25C | 15064744 | SIGNOR-123713 |
| p38 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 11333986 | SIGNOR-107420 |
| PLK3 | phosphorylation up-regulates → | CDC25C PSer198 | phosphorylation up-regulates → | CDC25C | 14968113 | SIGNOR-122094 |
| CDK1 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 10037602 | SIGNOR-64972 |
| CDK1 | phosphorylation up-regulates → | CDC25C PThr48 | phosphorylation up-regulates → | CDC25C | 8119945 | SIGNOR-36271 |
| CDK1 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 10037602 | SIGNOR-64960 |
| CDK1 | phosphorylation up-regulates → | CDC25C PThr130 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-78424 |
| PLK3 | phosphorylation up-regulates → | CDC25C PSer191 | phosphorylation up-regulates → | CDC25C | 14968113 | SIGNOR-122090 |
| MAPK10 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 20220133 | SIGNOR-164085 |
| PLK1 | phosphorylation up-regulates → | CDC25C PSer198 | phosphorylation up-regulates → | CDC25C | 11897663 | SIGNOR-115993 |
| CDK1 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 8119945 | SIGNOR-36279 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CDC25C PThr130 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-216769 |
| CDK1 | phosphorylation up-regulates → | CDC25C PThr48 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-78428 |
| MAPK8 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 20220133 | SIGNOR-164089 |
| CDK1 | phosphorylation up-regulates → | CDC25C PThr67 | phosphorylation up-regulates → | CDC25C | 8119945 | SIGNOR-36275 |
| ATR | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation up-regulates → | CDC25C | 28264028 | SIGNOR-279008 |
| CDK1 | phosphorylation up-regulates → | CDC25C PThr48 | phosphorylation up-regulates → | CDC25C | 10037602 | SIGNOR-64964 |
| PLK3 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 10557092 | SIGNOR-249030 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → up-regulates activity | CDC25C | SIGNOR-251510 |
| CHEK2 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-102779 |
| JNK | phosphorylation down-regulates | CDC25C | SIGNOR-269983 |
| BRSK1 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-107408 |
| CyclinB/CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-216765 |
| MAPK9 | phosphorylation down-regulates | CDC25C | SIGNOR-164093 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-36267 |
| PKN1 | phosphorylation → unknown | CDC25C | SIGNOR-249277 |
| CDK2 | phosphorylation → up-regulates | CDC25C | SIGNOR-165872 |
| ROBO | phosphorylation down-regulates | CDC25C | SIGNOR-124851 |
| CyclinB/CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-216741 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-78416 |
| CyclinB/CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-216777 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-64968 |
| BRSK1 | phosphorylation down-regulates | CDC25C | SIGNOR-56473 |
| MARK3 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-250176 |
| SYK | phosphorylation → down-regulates activity | CDC25C | SIGNOR-278328 |
| CyclinB/CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-216773 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-78432 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-78420 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | CDC25C | SIGNOR-163158 |
| CyclinE/CDK2 | phosphorylation → up-regulates | CDC25C | SIGNOR-216721 |
| MAPK14 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-250091 |
| CSNK2A1 | phosphorylation down-regulates | CDC25C | SIGNOR-123713 |
| p38 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-107420 |
| PLK3 | phosphorylation → up-regulates | CDC25C | SIGNOR-122094 |
| CDK1 | phosphorylation down-regulates | CDC25C | SIGNOR-64972 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-36271 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-64960 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-78424 |
| PIM1 | phosphorylation → up-regulates activity | CDC25C | SIGNOR-278298 |
| PLK3 | phosphorylation → up-regulates | CDC25C | SIGNOR-122090 |
| MAPK10 | phosphorylation down-regulates | CDC25C | SIGNOR-164085 |
| PLK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-115993 |
| CDK1 | phosphorylation down-regulates | CDC25C | SIGNOR-36279 |
| CyclinB/CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-216769 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-78428 |
| MAPK8 | phosphorylation down-regulates | CDC25C | SIGNOR-164089 |
| PLK4 | phosphorylation → up-regulates quantity | CDC25C | SIGNOR-280074 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-36275 |
| ATR | phosphorylation → up-regulates activity | CDC25C | SIGNOR-279008 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-64964 |
| PLK3 | phosphorylation → unknown | CDC25C | SIGNOR-249030 |