| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKN1 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation unknown | 15791647 | SIGNOR-249277 |
| PLK3 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation unknown | 10557092 | SIGNOR-249030 |
| ATR | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation up-regulates activity | 28264028 | SIGNOR-279008 |
| CHEK2 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 12835754 | SIGNOR-102779 |
| SYK | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 25506060 | SIGNOR-278328 |
| BRSK1 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates | 9543386 | SIGNOR-56473 |
| MARK3 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 9543386 | SIGNOR-250176 |
| CHEK1 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates quantity by destabilization | 20068082 | SIGNOR-163158 |
| ROBO | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates | 15150265 | SIGNOR-124851 |
| BRSK1 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 15150265 | SIGNOR-107408 |
| MAPK14 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 9543386 | SIGNOR-250091 |
| p38 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates activity | 11333986 | SIGNOR-107420 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKN1 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 15791647 | SIGNOR-249277 |
| PLK3 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 10557092 | SIGNOR-249030 |
| ATR | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation up-regulates → | CDC25C | 28264028 | SIGNOR-279008 |
| CHEK2 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 12835754 | SIGNOR-102779 |
| SYK | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 25506060 | SIGNOR-278328 |
| BRSK1 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 9543386 | SIGNOR-56473 |
| MARK3 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 9543386 | SIGNOR-250176 |
| CHEK1 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 20068082 | SIGNOR-163158 |
| ROBO | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 15150265 | SIGNOR-124851 |
| BRSK1 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 15150265 | SIGNOR-107408 |
| MAPK14 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 9543386 | SIGNOR-250091 |
| p38 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 11333986 | SIGNOR-107420 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKN1 | phosphorylation → unknown | CDC25C | SIGNOR-249277 |
| PLK3 | phosphorylation → unknown | CDC25C | SIGNOR-249030 |
| ATR | phosphorylation → up-regulates activity | CDC25C | SIGNOR-279008 |
| CHEK2 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-102779 |
| SYK | phosphorylation → down-regulates activity | CDC25C | SIGNOR-278328 |
| BRSK1 | phosphorylation down-regulates | CDC25C | SIGNOR-56473 |
| MARK3 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-250176 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | CDC25C | SIGNOR-163158 |
| ROBO | phosphorylation down-regulates | CDC25C | SIGNOR-124851 |
| BRSK1 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-107408 |
| MAPK14 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-250091 |
| p38 | phosphorylation → down-regulates activity | CDC25C | SIGNOR-107420 |
