| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 10864927 | SIGNOR-78420 |
| CyclinB/CDK1 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 10864927 | SIGNOR-216765 |
| CyclinE/CDK2 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 20530684 | SIGNOR-216721 |
| CDK1 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 8119945 | SIGNOR-36267 |
| CDK1 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 10037602 | SIGNOR-64960 |
| CDK2 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 20530684 | SIGNOR-165872 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-78420 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 10864927 | SIGNOR-216765 |
| CyclinE/CDK2 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 20530684 | SIGNOR-216721 |
| CDK1 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 8119945 | SIGNOR-36267 |
| CDK1 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 10037602 | SIGNOR-64960 |
| CDK2 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 20530684 | SIGNOR-165872 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-78420 |
| CyclinB/CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-216765 |
| CyclinE/CDK2 | phosphorylation → up-regulates | CDC25C | SIGNOR-216721 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-36267 |
| CDK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-64960 |
| CDK2 | phosphorylation → up-regulates | CDC25C | SIGNOR-165872 |
