| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 20220133 | SIGNOR-164093 |
| MAPK8 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 20220133 | SIGNOR-164089 |
| CDK1 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 10037602 | SIGNOR-64972 |
| CDK1 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 8119945 | SIGNOR-36279 |
| MAPK10 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 20220133 | SIGNOR-164085 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 20220133 | SIGNOR-164093 |
| MAPK8 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 20220133 | SIGNOR-164089 |
| CDK1 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 10037602 | SIGNOR-64972 |
| CDK1 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 8119945 | SIGNOR-36279 |
| MAPK10 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 20220133 | SIGNOR-164085 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK9 | phosphorylation down-regulates | CDC25C | SIGNOR-164093 |
| MAPK8 | phosphorylation down-regulates | CDC25C | SIGNOR-164089 |
| CDK1 | phosphorylation down-regulates | CDC25C | SIGNOR-64972 |
| CDK1 | phosphorylation down-regulates | CDC25C | SIGNOR-36279 |
| MAPK10 | phosphorylation down-regulates | CDC25C | SIGNOR-164085 |
