| Name | AKT1 |
| ID | P31749 |
| Role | substrate |
| Enzymatic Domains |
PH 5-108 PROSITE-ProRule
Protein kinase 150-408 PROSITE-ProRule
AGC-kinase C-terminal 409-480 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMKK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 10833263 | SIGNOR-252609 |
| MTOR | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21592956 | SIGNOR-217869 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates | 12167717 | SIGNOR-91354 |
| TNK2 | AKT1 | Tyr176 | EKATGRYyAMKILKK | phosphorylation up-regulates activity | 20333297 | SIGNOR-252446 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates | 10226025 | SIGNOR-67363 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 19951971 | SIGNOR-249629 |
| mTORC2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21592956 | SIGNOR-217012 |
| LRRK2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 24916379 | SIGNOR-252598 |
| SRC | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates activity | 11445557 | SIGNOR-252620 |
| mTORC2 | AKT1 | Thr450 | TAQMITItPPDQDDS | phosphorylation up-regulates activity | 18566586 | SIGNOR-252438 |
| ACP1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248455 |
| PTPA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 21159657 | SIGNOR-252607 |
| mTORC2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21157483 | SIGNOR-217004 |
| PPP2CA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 15367694 | SIGNOR-252606 |
| PP2CA_R1A_R2A | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 18042541 | SIGNOR-252613 |
| MAPK4 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 30688659 | SIGNOR-275450 |
| PPP2CA | AKT1 | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 11839802 | SIGNOR-252616 |
| PI3K | AKT1 | – | phosphorylation up-regulates activity | 15829723 | SIGNOR-255106 | |
| PTK6 | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 20606012 | SIGNOR-252618 |
| MTOR | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-252599 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates | 12808134 | SIGNOR-252611 |
| PRKDC | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 18439899 | SIGNOR-252431 |
| PHLPP1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248327 |
| LRRK2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 21658387 | SIGNOR-174044 |
| mTORC2 | AKT1 | Thr479 | FSYSASGtA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252444 |
| TBK1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 21329883 | SIGNOR-252608 |
| SRC | AKT1 | Tyr326 | EVLEDNDyGRAVDWW | phosphorylation up-regulates activity | 11445557 | SIGNOR-252623 |
| PDK1 | AKT1 | – | phosphorylation up-regulates activity | 15068796 | SIGNOR-278973 | |
| PDPK2P | AKT1 | – | phosphorylation up-regulates | 15505410 | SIGNOR-252628 | |
| PPP2CB | AKT1 | – | dephosphorylation down-regulates | 8650155 | SIGNOR-252636 | |
| AKT1 | AKT1 | Thr72 | TERPRPNtFIIRCLQ | phosphorylation up-regulates activity | 16549426 | SIGNOR-276054 |
| ILK | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 9736715 | SIGNOR-252597 |
| PTK6 | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 15994200 | SIGNOR-252617 |
| PDK2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 19951971 | SIGNOR-249630 |
| ILK | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 11313365 | SIGNOR-252596 |
| CSNK2A1 | AKT1 | Ser129 | SGSPSDNsGAEEMEV | phosphorylation up-regulates | 15818404 | SIGNOR-135203 |
| PHLPP2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15808505 | SIGNOR-252602 |
| AKT1 | AKT1 | Ser246 | LSRERVFsEDRARFY | phosphorylation up-regulates activity | 16549426 | SIGNOR-276055 |
| PP1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-264658 |
| PTPN1 | AKT1 | – | dephosphorylation down-regulates | 15632081 | SIGNOR-252639 | |
| PTPRF | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15896785 | SIGNOR-137246 |
| SRC | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates activity | 12600984 | SIGNOR-252621 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates | 21798082 | SIGNOR-175675 |
| mTORC2 | AKT1 | Ser477 | PQFSYSAsGTA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252441 |
| CyclinA2/CDK2 | AKT1 | Thr479 | FSYSASGtA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252443 |
| INPP4B | AKT1 | – | dephosphorylation down-regulates activity | 24070612 | SIGNOR-277106 | |
| MTOR | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21157483 | SIGNOR-170604 |
| CyclinA2/CDK2 | AKT1 | Ser477 | PQFSYSAsGTA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252440 |
| PPP1CA | AKT1 | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 20186153 | SIGNOR-163961 |
| PTK6 | AKT1 | Tyr326 | EVLEDNDyGRAVDWW | phosphorylation up-regulates | 20606012 | SIGNOR-252622 |
| PPP1CC | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-252605 |
| RET | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 15994200 | SIGNOR-252619 |
| PPP1CB | AKT1 | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 20186153 | SIGNOR-163965 |
| MAPK8 | AKT1 | Thr450 | TAQMITItPPDQDDS | phosphorylation up-regulates activity | 16306447 | SIGNOR-252426 |
| PPP2CA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248628 |
| PPP1CA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-252603 |
| PPP1CB | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-252604 |
| PPP2R5B | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates | 16495456 | SIGNOR-252615 |
| PHLPP2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248728 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 15718470 | SIGNOR-252612 |
| PPP2CA | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-252614 |
| PPP2CA | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248626 |
| CSNK2A1 | AKT1 | Ser129 | SGSPSDNsGAEEMEV | phosphorylation up-regulates | 21735093 | SIGNOR-252595 |
| mTORC2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-252600 |
| PHLPP1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15808505 | SIGNOR-252601 |
| GSK3A | AKT1 | Thr312 | TMKTFCGtPEYLAPE | phosphorylation down-regulates activity | 23142783 | SIGNOR-252434 |
| PDPK1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 10226025 | SIGNOR-67367 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMKK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 10833263 | SIGNOR-252609 |
| MTOR | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21592956 | SIGNOR-217869 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 12167717 | SIGNOR-91354 |
| TNK2 | phosphorylation up-regulates → | AKT1 PTyr176 | phosphorylation up-regulates → | AKT1 | 20333297 | SIGNOR-252446 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 10226025 | SIGNOR-67363 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 19951971 | SIGNOR-249629 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21592956 | SIGNOR-217012 |
| LRRK2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 24916379 | SIGNOR-252598 |
| SRC | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 11445557 | SIGNOR-252620 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PThr450 | phosphorylation up-regulates → | AKT1 | 18566586 | SIGNOR-252438 |
| ACP1 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 17353188 | SIGNOR-248455 |
| PTPA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 21159657 | SIGNOR-252607 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21157483 | SIGNOR-217004 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 15367694 | SIGNOR-252606 |
| PP2CA_R1A_R2A | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 18042541 | SIGNOR-252613 |
| MAPK4 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 30688659 | SIGNOR-275450 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PThr450 | dephosphorylation up-regulates → | AKT1 | 11839802 | SIGNOR-252616 |
| PTK6 | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 20606012 | SIGNOR-252618 |
| MTOR | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 15718470 | SIGNOR-252599 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 12808134 | SIGNOR-252611 |
| PRKDC | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 18439899 | SIGNOR-252431 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 19261608 | SIGNOR-248327 |
| LRRK2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21658387 | SIGNOR-174044 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PThr479 | phosphorylation up-regulates → | AKT1 | 24670654 | SIGNOR-252444 |
| TBK1 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21329883 | SIGNOR-252608 |
| SRC | phosphorylation up-regulates → | AKT1 PTyr326 | phosphorylation up-regulates → | AKT1 | 11445557 | SIGNOR-252623 |
| AKT1 | phosphorylation up-regulates → | AKT1 PThr72 | phosphorylation up-regulates → | AKT1 | 16549426 | SIGNOR-276054 |
| ILK | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 9736715 | SIGNOR-252597 |
| PTK6 | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 15994200 | SIGNOR-252617 |
| PDK2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 19951971 | SIGNOR-249630 |
| ILK | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 11313365 | SIGNOR-252596 |
| CSNK2A1 | phosphorylation up-regulates → | AKT1 PSer129 | phosphorylation up-regulates → | AKT1 | 15818404 | SIGNOR-135203 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 15808505 | SIGNOR-252602 |
| AKT1 | phosphorylation up-regulates → | AKT1 PSer246 | phosphorylation up-regulates → | AKT1 | 16549426 | SIGNOR-276055 |
| PP1 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-264658 |
| PTPRF | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 15896785 | SIGNOR-137246 |
| SRC | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 12600984 | SIGNOR-252621 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 21798082 | SIGNOR-175675 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer477 | phosphorylation up-regulates → | AKT1 | 24670654 | SIGNOR-252441 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | AKT1 PThr479 | phosphorylation up-regulates → | AKT1 | 24670654 | SIGNOR-252443 |
| MTOR | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21157483 | SIGNOR-170604 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | AKT1 PSer477 | phosphorylation up-regulates → | AKT1 | 24670654 | SIGNOR-252440 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AKT1 PThr450 | dephosphorylation up-regulates → | AKT1 | 20186153 | SIGNOR-163961 |
| PTK6 | phosphorylation up-regulates → | AKT1 PTyr326 | phosphorylation up-regulates → | AKT1 | 20606012 | SIGNOR-252622 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-252605 |
| RET | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 15994200 | SIGNOR-252619 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AKT1 PThr450 | dephosphorylation up-regulates → | AKT1 | 20186153 | SIGNOR-163965 |
| MAPK8 | phosphorylation up-regulates → | AKT1 PThr450 | phosphorylation up-regulates → | AKT1 | 16306447 | SIGNOR-252426 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 18160256 | SIGNOR-248628 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-252603 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-252604 |
| PPP2R5B | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 16495456 | SIGNOR-252615 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 19261608 | SIGNOR-248728 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 15718470 | SIGNOR-252612 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 15367694 | SIGNOR-252614 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 18160256 | SIGNOR-248626 |
| CSNK2A1 | phosphorylation up-regulates → | AKT1 PSer129 | phosphorylation up-regulates → | AKT1 | 21735093 | SIGNOR-252595 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 15718470 | SIGNOR-252600 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 15808505 | SIGNOR-252601 |
| GSK3A | phosphorylation up-regulates → | AKT1 PThr312 | phosphorylation down-regulates ⊣ | AKT1 | 23142783 | SIGNOR-252434 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 10226025 | SIGNOR-67367 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMKK1 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252609 |
| MTOR | phosphorylation → up-regulates activity | AKT1 | SIGNOR-217869 |
| PDPK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-91354 |
| TNK2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252446 |
| PDPK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-67363 |
| PDPK1 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-249629 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-217012 |
| LRRK2 | phosphorylation → up-regulates | AKT1 | SIGNOR-252598 |
| SRC | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252620 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252438 |
| ACP1 | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248455 |
| PTPA | dephosphorylation down-regulates | AKT1 | SIGNOR-252607 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-217004 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252606 |
| PP2CA_R1A_R2A | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252613 |
| MAPK4 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-275450 |
| PPP2CA | dephosphorylation down-regulates | AKT1 | SIGNOR-252616 |
| PI3K | phosphorylation → up-regulates activity | AKT1 | SIGNOR-255106 |
| PTK6 | phosphorylation → up-regulates | AKT1 | SIGNOR-252618 |
| MTOR | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252599 |
| PDPK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-252611 |
| PRKDC | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252431 |
| PHLPP1 | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248327 |
| LRRK2 | phosphorylation → up-regulates | AKT1 | SIGNOR-174044 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252444 |
| TBK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-252608 |
| SRC | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252623 |
| PDK1 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-278973 |
| PDPK2P | phosphorylation → up-regulates | AKT1 | SIGNOR-252628 |
| PPP2CB | dephosphorylation down-regulates | AKT1 | SIGNOR-252636 |
| AKT1 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-276054 |
| ILK | phosphorylation → up-regulates | AKT1 | SIGNOR-252597 |
| PTK6 | phosphorylation → up-regulates | AKT1 | SIGNOR-252617 |
| PDK2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-249630 |
| ILK | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252596 |
| CSNK2A1 | phosphorylation → up-regulates | AKT1 | SIGNOR-135203 |
| PHLPP2 | dephosphorylation down-regulates | AKT1 | SIGNOR-252602 |
| AKT1 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-276055 |
| PP1 | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-264658 |
| PTPN1 | dephosphorylation down-regulates | AKT1 | SIGNOR-252639 |
| PTPRF | dephosphorylation down-regulates | AKT1 | SIGNOR-137246 |
| SRC | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252621 |
| PDPK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-175675 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252441 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252443 |
| INPP4B | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-277106 |
| MTOR | phosphorylation → up-regulates activity | AKT1 | SIGNOR-170604 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252440 |
| PPP1CA | dephosphorylation down-regulates | AKT1 | SIGNOR-163961 |
| PTK6 | phosphorylation → up-regulates | AKT1 | SIGNOR-252622 |
| PPP1CC | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252605 |
| RET | phosphorylation → up-regulates | AKT1 | SIGNOR-252619 |
| PPP1CB | dephosphorylation down-regulates | AKT1 | SIGNOR-163965 |
| MAPK8 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252426 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248628 |
| PPP1CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252603 |
| PPP1CB | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252604 |
| PPP2R5B | dephosphorylation down-regulates | AKT1 | SIGNOR-252615 |
| PHLPP2 | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248728 |
| PDPK1 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252612 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252614 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248626 |
| CSNK2A1 | phosphorylation → up-regulates | AKT1 | SIGNOR-252595 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252600 |
| PHLPP1 | dephosphorylation down-regulates | AKT1 | SIGNOR-252601 |
| GSK3A | phosphorylation → down-regulates activity | AKT1 | SIGNOR-252434 |
| PDPK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-67367 |