Summary

Name AKT1
Full Name RAC-alpha serine/threonine-protein kinase
Synonyms Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha | PKB, RAC
Primary ID P31749
Links - -
Type protein
Relations 388
Pathways Adipogenesis, FAP: PDGFR alpha, FLT3-ITD signaling, Myofiber: IGF1R, P38 Signaling and Myogenesis, Parkinson, Satellite: IGF1, Satellite: miRNA network
Inhibitors perifosine; 3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]-4-piperidinyl]-1H-benzimidazol-2-one; GSK690693; PF-04691502; (2s)-1-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-Phenylpropan-2-Amine; MK-2206
Function AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (By similarity). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase) (PubMed:11154276). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis (PubMed:11154276). AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1 (PubMed:12150915). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization (PubMed:10358075). In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319' (PubMed:10358075). FOXO3 and FOXO4 are phosphorylated on equivalent sites (PubMed:10358075). AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein) (PubMed:9829964). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (PubMed:9829964). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (PubMed:12176338, PubMed:12964941). AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png deacetylation AKT1 0.626
Publications: 1 Organism: Mus Musculus
Tissue: Heart
+ down-regulates quantity by destabilization img/direct_inhibition.png desumoylation AKT1 0.286
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png sumoylation AKT1 0.388
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT1 0.492
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation YBX1 0.581
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.757
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation LARP1 0.294
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation H3-3A 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PALLD 0.422
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation FANCA 0.474
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PEA15 0.537
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TENT2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS3 0.874
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.815
Publications: 4 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.762
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, FLT3-ITD signaling, Glioblastoma Multiforme
+ up-regulates activity img/direct-activation.png phosphorylation DOCK6 0.385
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation KDM5A 0.31
Publications: 5 Organism: In Vitro
+ img/unknown.png phosphorylation RANBP3 0.371
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation YAP1 0.619
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.38
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.503
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation MST1R 0.536
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CCDC88A 0.621
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ZYX 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DNMT1 0.548
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MXD1 0.37
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NCOR1 0.441
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.834
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation GAB2 0.687
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation MDM2 0.803
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation LONP1 0.256
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EP300 0.684
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation BAX 0.503
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation MDM2 0.803
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation MDM2 0.803
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
Pathways:FLT3-ITD signaling
+ img/unknown.png phosphorylation HMOX1 0.583
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KHSRP 0.691
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.768
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.768
Publications: 2 Organism: In Vitro, Homo Sapiens
Pathways:Parkinson
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO4 0.755
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation FOXO4 0.755
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.909
Publications: 7 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization FOXO 0.909
Publications: 10 Organism: Homo Sapiens, In Vitro, Mus Musculus
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPA1 0.427
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A 0.616
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EZH2 0.62
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation HTRA2 0.332
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson
+ down-regulates activity img/direct_inhibition.png phosphorylation AR 0.611
Publications: 2 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation AR 0.611
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TMIGD2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TERT 0.722
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BLVRA 0.303
Publications: 1
+ down-regulates quantity img/direct_inhibition.png phosphorylation SYTL1 0.367
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MTOR 0.928
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Glioblastoma Multiforme, Parkinson
+ up-regulates img/direct-activation.png phosphorylation TP53RK 0.302
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.909
Publications: 4 Organism: , Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.908
Publications: 4 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.908
Publications: 3
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1 0.866
Publications: 3 Organism: In Vitro, Mus Musculus
Pathways:Adipogenesis, IGF and Myogenesis
+ up-regulates quantity img/direct-activation.png phosphorylation ITCH 0.327
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.683
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Myotube
Pathways:Adipogenesis
+ img/unknown.png phosphorylation ARFIP2 0.476
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CCT2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation METTL1 0.341
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CFLAR 0.487
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CHEK1 0.443
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1C 0.461
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TARBP2 0.2
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PHF20 0.531
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PDE3B 0.678
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation PDE3B 0.678
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.582
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SH3RF1 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIKFYVE 0.513
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation GATA1 0.533
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BMI1 0.455
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization FOXO1 0.866
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:Adipogenesis, IGF and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation ATG4B
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CLK2 0.399
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ADRB2 0.366
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NR4A1 0.718
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VCP 0.527
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.471
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Glioblastoma Multiforme
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation MDM4 0.528
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TTC3 0.405
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation VIM 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation ACOT4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K8 0.534
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GATA2 0.544
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ img/unknown.png phosphorylation HTT 0.575
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TWIST1 0.457
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EIF4B 0.408
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation USP14 0.441
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation USP4 0.482
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ACLY 0.444
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation PDCD4 0.454
Publications: 3 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation PFKFB3 0.444
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.642
Publications: 4 Organism: Homo Sapiens
Tissue: Heart
+ img/unknown.png phosphorylation PFKFB2 0.642
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.766
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.928
Publications: 3 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Glioblastoma Multiforme, Parkinson
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.634
Publications: 6 Organism: Homo Sapiens, Mus Musculus
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.887
Publications: 4 Organism: Homo Sapiens, Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.73
Publications: 5 Organism: Homo Sapiens
Tissue: Brain
Pathways:Adipogenesis, FLT3-ITD signaling, Glioblastoma Multiforme, IGF and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.418
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.388
Publications: 2 Organism: Homo Sapiens
Pathways:Parkinson
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.752
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.766
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.74
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.772
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.772
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.752
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.394
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.438
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.395
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.744
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.351
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.33
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.43
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPN1 0.732
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation CARHSP1 0.352
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.799
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ img/unknown.png phosphorylation ACAP1 0.5
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPARGC1A 0.463
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ img/unknown.png phosphorylation YWHAZ 0.656
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SH2B2 0.41
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation SH2B2 0.41
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation COPS6 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NUAK1 0.267
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NIBAN1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NOS3 0.874
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ILF3 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K11 0.411
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.525
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAC1 0.713
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DLC1 0.513
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation ATXN1 0.422
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ZRANB1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP2K4 0.577
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.687
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.712
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2L11 0.592
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation XIAP 0.642
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary Cancer Cell
Pathways:Parkinson
+ down-regulates activity img/direct_inhibition.png phosphorylation, GSK3B 0.778
Publications: 3 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Adipogenesis, FLT3-ITD signaling, IGF and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation ZFP36L1 0.64
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.812
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation MVD 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation RARA 0.58
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DAB2IP 0.516
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AGAP2 0.515
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRAK1 0.396
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STK3 0.363
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STK4 0.408
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PARK7 0.484
Publications: 1
+ down-regulates quantity img/direct_inhibition.png phosphorylation RNF11 0.472
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation UBE2S 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation, binding CDKN1B 0.845
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDCA7 0.349
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PLN 0.295
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ALYREF 0.464
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHUK 0.648
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation POU5F1 0.478
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation S1PR1 0.691
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AKT1S1 0.776
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.73
Publications: 2 Organism: Homo Sapiens,
Pathways:Adipogenesis, FLT3-ITD signaling, Glioblastoma Multiforme, IGF and Myogenesis
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.645
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.388
Publications: 1
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.275
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.669
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation AKT1 0.616
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation LTB4R2 0.391
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TKT 0.289
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK2 0.337
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.395
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.438
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.441
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.887
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SKI 0.342
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCYL1 0.259
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HK2 0.464
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRPK2 0.482
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation WNK1 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PIK3R6 0.422
Publications: 1
+ img/unknown.png phosphorylation TBC1D4 0.757
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS3 0.381
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGB3 0.593
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TIFA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TAL1 0.388
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.439
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.66
Publications: 3 Organism: Homo Sapiens, Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.45
Publications: 3 Organism: Homo Sapiens
Tissue: Prostate Gland
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.331
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TBC1D4 0.757
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination AKT1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A1 0.571
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png AKT1 0.785
Publications: 4 Organism: Homo Sapiens
Tissue: Colonic Cancer Cell, Breast Cancer Cell
Pathways:FLT3-ITD signaling
+ up-regulates activity img/indirect-activation.png AKT1 0.812
Publications: 4 Organism: Homo Sapiens
Tissue: Breast Cancer Cell, Colonic Cancer Cell
Pathways:Glioblastoma Multiforme, IGF and Myogenesis
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.483
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation mTORC1 0.72
Publications: 2 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ down-regulates img/direct_inhibition.png chemical inhibition AKT1 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation AKT1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AKT1 0.8
Publications: 2 Organism: Homo Sapiens,
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.732
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AKT1 0.473
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png AKT1 0.634
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT1 0.525
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png AKT1 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/direct-activation.png binding AKT1 0.345
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DLX5 0.269
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.845
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AKT1 0.599
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO1 0.866
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, IGF and Myogenesis
+ up-regulates activity img/indirect-activation.png AKT1 0.448
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/direct-activation.png binding AKT1 0.824
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png AKT1 0.746
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation P300/PCAF 0.597
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding HK1 0.463
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png AKT1 0.468
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:FLT3-ITD signaling
+ up-regulates img/indirect-activation.png AKT1 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT1 0.453
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SP7 0.44
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PRKACA 0.254
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SLC2A4 0.573
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization AKT1 0.8
Publications: 3 Organism: Homo Sapiens
Pathways:Adipogenesis, FLT3-ITD signaling, Glioblastoma Multiforme
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC 0.778
Publications: 2 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png AKT1 0.387
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png AKT1 0.451
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding SMAD3 0.648
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation mTORC1 0.72
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Glioblastoma Multiforme
+ down-regulates activity img/direct_inhibition.png cleavage AKT1 0.629
Publications: 1 Organism: In Vitro
Pathways:Parkinson
+ down-regulates img/indirect_inhibition.png AKT1 0.367
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MEF2D 0.584
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png cleavage AKT1 0.629
Publications: 1 Organism: In Vitro
+ down-regulates img/indirect_inhibition.png FAS 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png AKT1 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Fibrosis 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding AKT1 0.685
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AKT1 0.8
Publications: 2 Organism: In Vitro
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Glioblastoma Multiforme
+ down-regulates activity img/indirect_inhibition.png AKT1 0.252
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FSTL1 0.398
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png AKT1 0.49
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/indirect-activation.png AKT1 0.411
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MEF2C 0.531
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates img/indirect-activation.png AKT1 0.502
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation IMPDH2 0.396
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.298
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding AKT1 0.663
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PHB2 0.504
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.785
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation FOXO6 0.635
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AKT1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/indirect_inhibition.png AKT1 0.662
Publications: 2 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ up-regulates img/direct-activation.png relocalization AKT1 0.451
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation Hexokinase 0.504
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STK3/4 0.408
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT1 0.405
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation IKK-complex 0.639
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/indirect-activation.png AKT1 0.401
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png chemical activation AKT1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MTOR 0.928
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:FLT3-ITD signaling, Glioblastoma Multiforme, Parkinson
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation AKT1 0.478
Publications: 1 Organism: Homo Sapiens