Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PPP2R5B	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	dephosphorylation down-regulates	16495456	SIGNOR-252615
PDPK1	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	phosphorylation up-regulates activity	15718470	SIGNOR-252612
PPP2CA	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	dephosphorylation down-regulates activity	15367694	SIGNOR-252614
PPP2CA	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	dephosphorylation down-regulates activity	18160256	SIGNOR-248626
CAMKK1	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	phosphorylation up-regulates activity	10833263	SIGNOR-252609
PDPK1	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	phosphorylation up-regulates	12167717	SIGNOR-91354
PDPK1	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	phosphorylation up-regulates	10226025	SIGNOR-67363
PDPK1	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	phosphorylation up-regulates activity	19951971	SIGNOR-249629
PP2CA_R1A_R2A	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	dephosphorylation down-regulates activity	18042541	SIGNOR-252613
MAPK4	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	phosphorylation up-regulates activity	30688659	SIGNOR-275450
PDPK1	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	phosphorylation up-regulates	12808134	SIGNOR-252611
PDPK1	AKT1	Thr308 View in OncoXplorer	KDGATMKtFCGTPEY	phosphorylation up-regulates	21798082	SIGNOR-175675

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PPP2R5B	dephosphorylation down-regulates ⊣	AKT1 PThr308	dephosphorylation up-regulates →	AKT1	16495456	SIGNOR-252615
PDPK1	phosphorylation up-regulates →	AKT1 PThr308	phosphorylation up-regulates →	AKT1	15718470	SIGNOR-252612
PPP2CA	dephosphorylation down-regulates ⊣	AKT1 PThr308	dephosphorylation up-regulates →	AKT1	15367694	SIGNOR-252614
PPP2CA	dephosphorylation down-regulates ⊣	AKT1 PThr308	dephosphorylation up-regulates →	AKT1	18160256	SIGNOR-248626
CAMKK1	phosphorylation up-regulates →	AKT1 PThr308	phosphorylation up-regulates →	AKT1	10833263	SIGNOR-252609
PDPK1	phosphorylation up-regulates →	AKT1 PThr308	phosphorylation up-regulates →	AKT1	12167717	SIGNOR-91354
PDPK1	phosphorylation up-regulates →	AKT1 PThr308	phosphorylation up-regulates →	AKT1	10226025	SIGNOR-67363
PDPK1	phosphorylation up-regulates →	AKT1 PThr308	phosphorylation up-regulates →	AKT1	19951971	SIGNOR-249629
PP2CA_R1A_R2A	dephosphorylation down-regulates ⊣	AKT1 PThr308	dephosphorylation up-regulates →	AKT1	18042541	SIGNOR-252613
MAPK4	phosphorylation up-regulates →	AKT1 PThr308	phosphorylation up-regulates →	AKT1	30688659	SIGNOR-275450
PDPK1	phosphorylation up-regulates →	AKT1 PThr308	phosphorylation up-regulates →	AKT1	12808134	SIGNOR-252611
PDPK1	phosphorylation up-regulates →	AKT1 PThr308	phosphorylation up-regulates →	AKT1	21798082	SIGNOR-175675

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PPP2R5B	dephosphorylation down-regulates	AKT1	SIGNOR-252615
PDPK1	phosphorylation → up-regulates activity	AKT1	SIGNOR-252612
PPP2CA	dephosphorylation → down-regulates activity	AKT1	SIGNOR-252614
PPP2CA	dephosphorylation → down-regulates activity	AKT1	SIGNOR-248626
CAMKK1	phosphorylation → up-regulates activity	AKT1	SIGNOR-252609
PDPK1	phosphorylation → up-regulates	AKT1	SIGNOR-91354
PDPK1	phosphorylation → up-regulates	AKT1	SIGNOR-67363
PDPK1	phosphorylation → up-regulates activity	AKT1	SIGNOR-249629
PP2CA_R1A_R2A	dephosphorylation → down-regulates activity	AKT1	SIGNOR-252613
MAPK4	phosphorylation → up-regulates activity	AKT1	SIGNOR-275450
PDPK1	phosphorylation → up-regulates	AKT1	SIGNOR-252611
PDPK1	phosphorylation → up-regulates	AKT1	SIGNOR-175675