| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | AKT1 | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 20186153 | SIGNOR-163961 |
| PPP1CB | AKT1 | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 20186153 | SIGNOR-163965 |
| MAPK8 | AKT1 | Thr450 | TAQMITItPPDQDDS | phosphorylation up-regulates activity | 16306447 | SIGNOR-252426 |
| mTORC2 | AKT1 | Thr450 | TAQMITItPPDQDDS | phosphorylation up-regulates activity | 18566586 | SIGNOR-252438 |
| PPP2CA | AKT1 | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 11839802 | SIGNOR-252616 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | dephosphorylation down-regulates ⊣ | AKT1 PThr450 | dephosphorylation up-regulates → | AKT1 | 20186153 | SIGNOR-163961 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AKT1 PThr450 | dephosphorylation up-regulates → | AKT1 | 20186153 | SIGNOR-163965 |
| MAPK8 | phosphorylation up-regulates → | AKT1 PThr450 | phosphorylation up-regulates → | AKT1 | 16306447 | SIGNOR-252426 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PThr450 | phosphorylation up-regulates → | AKT1 | 18566586 | SIGNOR-252438 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PThr450 | dephosphorylation up-regulates → | AKT1 | 11839802 | SIGNOR-252616 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP1CA | dephosphorylation down-regulates | AKT1 | SIGNOR-163961 |
| PPP1CB | dephosphorylation down-regulates | AKT1 | SIGNOR-163965 |
| MAPK8 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252426 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252438 |
| PPP2CA | dephosphorylation down-regulates | AKT1 | SIGNOR-252616 |
