| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK4 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 30688659 | SIGNOR-275450 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates | 12808134 | SIGNOR-252611 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates | 21798082 | SIGNOR-175675 |
| PPP2R5B | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates | 16495456 | SIGNOR-252615 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 15718470 | SIGNOR-252612 |
| PPP2CA | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 15367694 | SIGNOR-252614 |
| PPP2CA | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248626 |
| CAMKK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 10833263 | SIGNOR-252609 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates | 12167717 | SIGNOR-91354 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates | 10226025 | SIGNOR-67363 |
| PDPK1 | AKT1 | Thr308 | KDGATMKtFCGTPEY | phosphorylation up-regulates activity | 19951971 | SIGNOR-249629 |
| PP2CA_R1A_R2A | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates activity | 18042541 | SIGNOR-252613 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK4 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 30688659 | SIGNOR-275450 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 12808134 | SIGNOR-252611 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 21798082 | SIGNOR-175675 |
| PPP2R5B | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 16495456 | SIGNOR-252615 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 15718470 | SIGNOR-252612 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 15367694 | SIGNOR-252614 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 18160256 | SIGNOR-248626 |
| CAMKK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 10833263 | SIGNOR-252609 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 12167717 | SIGNOR-91354 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 10226025 | SIGNOR-67363 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PThr308 | phosphorylation up-regulates → | AKT1 | 19951971 | SIGNOR-249629 |
| PP2CA_R1A_R2A | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 18042541 | SIGNOR-252613 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK4 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-275450 |
| PDPK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-252611 |
| PDPK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-175675 |
| PPP2R5B | dephosphorylation down-regulates | AKT1 | SIGNOR-252615 |
| PDPK1 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252612 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252614 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248626 |
| CAMKK1 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252609 |
| PDPK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-91354 |
| PDPK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-67363 |
| PDPK1 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-249629 |
| PP2CA_R1A_R2A | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252613 |
