| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK6 | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 15994200 | SIGNOR-252617 |
| SRC | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates activity | 12600984 | SIGNOR-252621 |
| RET | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 15994200 | SIGNOR-252619 |
| SRC | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates activity | 11445557 | SIGNOR-252620 |
| PTK6 | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 20606012 | SIGNOR-252618 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK6 | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 15994200 | SIGNOR-252617 |
| SRC | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 12600984 | SIGNOR-252621 |
| RET | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 15994200 | SIGNOR-252619 |
| SRC | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 11445557 | SIGNOR-252620 |
| PTK6 | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 20606012 | SIGNOR-252618 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK6 | phosphorylation → up-regulates | AKT1 | SIGNOR-252617 |
| SRC | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252621 |
| RET | phosphorylation → up-regulates | AKT1 | SIGNOR-252619 |
| SRC | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252620 |
| PTK6 | phosphorylation → up-regulates | AKT1 | SIGNOR-252618 |
