| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21592956 | SIGNOR-217869 |
| PPP1CC | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-252605 |
| PTPA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 21159657 | SIGNOR-252607 |
| PTPRF | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15896785 | SIGNOR-137246 |
| PPP1CB | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-252604 |
| PPP2CA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 15367694 | SIGNOR-252606 |
| PHLPP2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15808505 | SIGNOR-252602 |
| ILK | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 11313365 | SIGNOR-252596 |
| MTOR | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21157483 | SIGNOR-170604 |
| PHLPP2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248728 |
| PP1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-264658 |
| mTORC2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-252600 |
| PPP1CA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-252603 |
| PRKDC | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 18439899 | SIGNOR-252431 |
| TBK1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 21329883 | SIGNOR-252608 |
| LRRK2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 24916379 | SIGNOR-252598 |
| PHLPP1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15808505 | SIGNOR-252601 |
| mTORC2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21157483 | SIGNOR-217004 |
| MTOR | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-252599 |
| ACP1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 17353188 | SIGNOR-248455 |
| ILK | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 9736715 | SIGNOR-252597 |
| mTORC2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21592956 | SIGNOR-217012 |
| LRRK2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 21658387 | SIGNOR-174044 |
| PDK2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 19951971 | SIGNOR-249630 |
| PDPK1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates | 10226025 | SIGNOR-67367 |
| PHLPP1 | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 19261608 | SIGNOR-248327 |
| PPP2CA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 18160256 | SIGNOR-248628 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21592956 | SIGNOR-217869 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-252605 |
| PTPA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 21159657 | SIGNOR-252607 |
| PTPRF | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 15896785 | SIGNOR-137246 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-252604 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 15367694 | SIGNOR-252606 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 15808505 | SIGNOR-252602 |
| ILK | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 11313365 | SIGNOR-252596 |
| MTOR | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21157483 | SIGNOR-170604 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 19261608 | SIGNOR-248728 |
| PP1 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-264658 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 15718470 | SIGNOR-252600 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-252603 |
| PRKDC | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 18439899 | SIGNOR-252431 |
| TBK1 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21329883 | SIGNOR-252608 |
| LRRK2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 24916379 | SIGNOR-252598 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 15808505 | SIGNOR-252601 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21157483 | SIGNOR-217004 |
| MTOR | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 15718470 | SIGNOR-252599 |
| ACP1 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 17353188 | SIGNOR-248455 |
| ILK | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 9736715 | SIGNOR-252597 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21592956 | SIGNOR-217012 |
| LRRK2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21658387 | SIGNOR-174044 |
| PDK2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 19951971 | SIGNOR-249630 |
| PDPK1 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 10226025 | SIGNOR-67367 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 19261608 | SIGNOR-248327 |
| PPP2CA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 18160256 | SIGNOR-248628 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → up-regulates activity | AKT1 | SIGNOR-217869 |
| PPP1CC | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252605 |
| PTPA | dephosphorylation down-regulates | AKT1 | SIGNOR-252607 |
| PTPRF | dephosphorylation down-regulates | AKT1 | SIGNOR-137246 |
| PPP1CB | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252604 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252606 |
| PHLPP2 | dephosphorylation down-regulates | AKT1 | SIGNOR-252602 |
| ILK | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252596 |
| MTOR | phosphorylation → up-regulates activity | AKT1 | SIGNOR-170604 |
| PHLPP2 | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248728 |
| PP1 | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-264658 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252600 |
| PPP1CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252603 |
| PRKDC | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252431 |
| TBK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-252608 |
| LRRK2 | phosphorylation → up-regulates | AKT1 | SIGNOR-252598 |
| PHLPP1 | dephosphorylation down-regulates | AKT1 | SIGNOR-252601 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-217004 |
| MTOR | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252599 |
| ACP1 | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248455 |
| ILK | phosphorylation → up-regulates | AKT1 | SIGNOR-252597 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-217012 |
| LRRK2 | phosphorylation → up-regulates | AKT1 | SIGNOR-174044 |
| PDK2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-249630 |
| PDPK1 | phosphorylation → up-regulates | AKT1 | SIGNOR-67367 |
| PHLPP1 | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248327 |
| PPP2CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-248628 |
