Entity Details

Name MC4R
ID P32245
Role substrate
Enzymatic Domains
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKACAMC4RSer329LGGLCDLsSRYphosphorylation
down-regulates activity		12639913SIGNOR-250016
PRKACAMC4RThr312RSQELRKtFKEIICCphosphorylation
down-regulates activity		12639913SIGNOR-250017
GRK2MC4RThr312RSQELRKtFKEIICCphosphorylation
down-regulates activity		12639913SIGNOR-247770
GRK2MC4RSer329LGGLCDLsSRYphosphorylation
down-regulates activity		12639913SIGNOR-251453
GRK2MC4RSer330GGLCDLSsRYphosphorylation
down-regulates activity		12639913SIGNOR-249673
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKACAphosphorylation
up-regulates
→
MC4R
PSer329		phosphorylation
down-regulates
⊣		MC4R12639913SIGNOR-250016
PRKACAphosphorylation
up-regulates
→
MC4R
PThr312		phosphorylation
down-regulates
⊣		MC4R12639913SIGNOR-250017
GRK2phosphorylation
up-regulates
→
MC4R
PThr312		phosphorylation
down-regulates
⊣		MC4R12639913SIGNOR-247770
GRK2phosphorylation
up-regulates
→
MC4R
PSer329		phosphorylation
down-regulates
⊣		MC4R12639913SIGNOR-251453
GRK2phosphorylation
up-regulates
→
MC4R
PSer330		phosphorylation
down-regulates
⊣		MC4R12639913SIGNOR-249673
Regulator Mechanism/Effect Target SIGNOR-ID
PRKACAphosphorylation
→
down-regulates activity 		MC4RSIGNOR-250016
PRKACAphosphorylation
→
down-regulates activity 		MC4RSIGNOR-250017
GRK2phosphorylation
→
down-regulates activity 		MC4RSIGNOR-247770
GRK2phosphorylation
→
down-regulates activity 		MC4RSIGNOR-251453
GRK2phosphorylation
→
down-regulates activity 		MC4RSIGNOR-249673