Summary

Name MC4R
Full Name Melanocortin receptor 4
Synonyms MC4-R
Primary ID P32245
Links - -
Type protein
Relations 27
Pathways Leptin Signaling
Function Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation MC4R 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MC4R 0.312
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MC4R 0.524
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNA12 0.251
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Food intake 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ down-regulates activity img/direct_inhibition.png binding MC4R 0.508
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png binding MC4R 0.768
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png binding MC4R 0.8
Publications: 1
Tissue: Hypothalamus
+ up-regulates activity img/direct-activation.png binding GNAL 0.273
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MC4R 0.772
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png binding GNAS 0.497
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png chemical activation MC4R 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA14 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAQ 0.251
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MC4R 0.52
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png binding MC4R 0.768
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png GNAS 0.497
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI3 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAZ 0.254
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MC4R 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain