| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | MC4R | Ser330 | GGLCDLSsRY | phosphorylation down-regulates activity | 12639913 | SIGNOR-249673 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | phosphorylation up-regulates → | MC4R PSer330 | phosphorylation down-regulates ⊣ | MC4R | 12639913 | SIGNOR-249673 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK2 | phosphorylation → down-regulates activity | MC4R | SIGNOR-249673 |