| Name | CIITA |
| ID | P33076 |
| Role | substrate |
| Enzymatic Domains |
NACHT 414-724 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | CIITA | Ser280 | TVHGLPTsPDRPGST | phosphorylation up-regulates | 17095509 | SIGNOR-150545 |
| MAPK1 | CIITA | Ser280 | TVHGLPTsPDRPGST | phosphorylation up-regulates | 15210796 | SIGNOR-126250 |
| MAPK1 | CIITA | Ser288 | PDRPGSTsPFAPSAT | phosphorylation down-regulates | 15210796 | SIGNOR-126254 |
| GSK3B | CIITA | Ser373 | VQARLERsSSKSLER | phosphorylation up-regulates | 17991736 | SIGNOR-158959 |
| MAPK1 | CIITA | Ser288 | PDRPGSTsPFAPSAT | phosphorylation down-regulates | 18245089 | SIGNOR-160613 |
| MAPK3 | CIITA | Ser288 | PDRPGSTsPFAPSAT | phosphorylation down-regulates | 18245089 | SIGNOR-160617 |
| ERK1/2 | CIITA | – | phosphorylation down-regulates | 18245089 | SIGNOR-270173 | |
| PRKACA | CIITA | Ser834 | QELPGRLsFLGTRLT | phosphorylation down-regulates activity | 11416140 | SIGNOR-108573 |
| MAPK1 | CIITA | Ser280 | TVHGLPTsPDRPGST | phosphorylation up-regulates | 18245089 | SIGNOR-160609 |
| Gbeta | CIITA | – | phosphorylation down-regulates | 18245089 | SIGNOR-270067 | |
| PRKACA | CIITA | Ser1050 | AASLLRLsLYNNCIC | phosphorylation down-regulates activity | 11416140 | SIGNOR-108569 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | CIITA PSer280 | phosphorylation up-regulates → | CIITA | 17095509 | SIGNOR-150545 |
| MAPK1 | phosphorylation up-regulates → | CIITA PSer280 | phosphorylation up-regulates → | CIITA | 15210796 | SIGNOR-126250 |
| MAPK1 | phosphorylation up-regulates → | CIITA PSer288 | phosphorylation down-regulates ⊣ | CIITA | 15210796 | SIGNOR-126254 |
| GSK3B | phosphorylation up-regulates → | CIITA PSer373 | phosphorylation up-regulates → | CIITA | 17991736 | SIGNOR-158959 |
| MAPK1 | phosphorylation up-regulates → | CIITA PSer288 | phosphorylation down-regulates ⊣ | CIITA | 18245089 | SIGNOR-160613 |
| MAPK3 | phosphorylation up-regulates → | CIITA PSer288 | phosphorylation down-regulates ⊣ | CIITA | 18245089 | SIGNOR-160617 |
| PRKACA | phosphorylation up-regulates → | CIITA PSer834 | phosphorylation down-regulates ⊣ | CIITA | 11416140 | SIGNOR-108573 |
| MAPK1 | phosphorylation up-regulates → | CIITA PSer280 | phosphorylation up-regulates → | CIITA | 18245089 | SIGNOR-160609 |
| PRKACA | phosphorylation up-regulates → | CIITA PSer1050 | phosphorylation down-regulates ⊣ | CIITA | 11416140 | SIGNOR-108569 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates | CIITA | SIGNOR-150545 |
| MAPK1 | phosphorylation → up-regulates | CIITA | SIGNOR-126250 |
| MAPK1 | phosphorylation down-regulates | CIITA | SIGNOR-126254 |
| GSK3B | phosphorylation → up-regulates | CIITA | SIGNOR-158959 |
| MAPK1 | phosphorylation down-regulates | CIITA | SIGNOR-160613 |
| MAPK3 | phosphorylation down-regulates | CIITA | SIGNOR-160617 |
| ERK1/2 | phosphorylation down-regulates | CIITA | SIGNOR-270173 |
| PRKACA | phosphorylation → down-regulates activity | CIITA | SIGNOR-108573 |
| MAPK1 | phosphorylation → up-regulates | CIITA | SIGNOR-160609 |
| Gbeta | phosphorylation down-regulates | CIITA | SIGNOR-270067 |
| PRKACA | phosphorylation → down-regulates activity | CIITA | SIGNOR-108569 |