Summary

Name CIITA
Full Name MHC class II transactivator
Synonyms CIITA | MHC2TA
Primary ID P33076
Links - -
Type protein
Relations 35
Function Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation CIITA 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png deacetylation CIITA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation IL4 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CIITA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MYOG 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DMA 0.14
Publications: 1
+ up-regulates activity img/direct-activation.png binding RFX5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png transcriptional regulation CIITA 0.23
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-C 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation S100A4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CIITA 0.23
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DPB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DMB 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-E 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-F 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png transcriptional regulation HLA-G 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation CIITA 0.23
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DOA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DOB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DQB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRB3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRB4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRB5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-A 0.14
Publications: 1 Organism: Homo Sapiens