| + |
PRKACA | down-regulates activity 
phosphorylation
|
CIITA |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108569 |
Ser1050 |
AASLLRLsLYNNCIC |
Homo sapiens |
P-388D1 Cell |
| pmid |
sentence |
| 11416140 |
Downregulation of ciita function by protein kinase a (pka)-mediated phosphorylation phosphorylation at ciita serines 834 and 1050 accounts for the inhibitory effects of pka on ciita-driven class ii mhc transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108573 |
Ser834 |
QELPGRLsFLGTRLT |
Homo sapiens |
P-388D1 Cell |
| pmid |
sentence |
| 11416140 |
Downregulation of ciita function by protein kinase a (pka)-mediated phosphorylationphosphorylation at ciita serines 834 and 1050 accounts for the inhibitory effects of pka on ciita-driven class ii mhc transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates 
phosphorylation
|
CIITA |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150545 |
Ser280 |
TVHGLPTsPDRPGST |
Homo sapiens |
T-lymphocyte, Macrophage |
| pmid |
sentence |
| 17095509 |
We found that in these cells, lipopolysaccharide stimulates the expression of mhc ii genes via the activation of erk1/2, which is mediated by toll-like receptor 4. Erk1/2 then phosphorylates the serine at position 357, which is located in a degron of ciita isoform 1 that leads to its monoubiquitylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | up-regulates
phosphorylation
|
CIITA |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126250 |
Ser280 |
TVHGLPTsPDRPGST |
Homo sapiens |
|
| pmid |
sentence |
| 15210796 |
We show in this study that the nuclear localized form of ciita is a predominantly phosphorylated form of the protein, whereas cytoplasmic ciita is predominantly unphosphorylated. Novel phosphorylation sites were determined to be located within a region that contains serine residues 286, 288, and 293. Double mutations of these residues increased nuclear ciita, indicating that these sites are not required for nuclear import. Erk1/2-mediated phosphorylation of ciita down-regulates ciita activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160609 |
Ser280 |
TVHGLPTsPDRPGST |
Homo sapiens |
|
| pmid |
sentence |
| 18245089 |
We show in this study that the nuclear localized form of ciita is a predominantly phosphorylated form of the protein, whereas cytoplasmic ciita is predominantly unphosphorylated. Novel phosphorylation sites were determined to be located within a region that contains serine residues 286, 288, and 293. Double mutations of these residues increased nuclear ciita, indicating that these sites are not required for nuclear import. Erk1/2-mediated phosphorylation of ciita down-regulates ciita activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates
phosphorylation
|
CIITA |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160617 |
Ser288 |
PDRPGSTsPFAPSAT |
Homo sapiens |
|
| pmid |
sentence |
| 18245089 |
In this study we show that the extracellular signal-regulated kinases 1 and 2 (erk1/2) interact directly with ciita, targeting serine residues in the amino terminus of the protein, including serine 288. These data suggest a model whereby erk1/2-mediated phosphorylation of ciita down-regulates ciita activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | down-regulates
phosphorylation
|
CIITA |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126254 |
Ser288 |
PDRPGSTsPFAPSAT |
Homo sapiens |
|
| pmid |
sentence |
| 15210796 |
Erk1/2-mediated phosphorylation of ciita down-regulates ciita activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160613 |
Ser288 |
PDRPGSTsPFAPSAT |
Homo sapiens |
|
| pmid |
sentence |
| 18245089 |
Novel phosphorylation sites were determined to be located within a region that contains serine residues 286, 288, and 293. ... Erk1/2-mediated phosphorylation of ciita down-regulates ciita activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GSK3B | up-regulates
phosphorylation
|
CIITA |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158959 |
Ser373 |
VQARLERsSSKSLER |
Homo sapiens |
|
| pmid |
sentence |
| 17991736 |
Here we report that CIITA represses collagen transcription through a phosphorylation-dependent interaction between its proline/serine/threonine domain and co-repressor molecules such as histone deacetylase (HDAC2) and Sin3B. Mutation of a serine (S373A) in CIITA, within a glycogen synthase kinase 3 (GSK3) consensus site, decreases repression of collagen transcription by blocking interaction with Sin3B |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression 
transcriptional regulation
|
HLA-DOA |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254005 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11823510 |
Class II transactivator is required for maximal expression of HLA-DOB in B cells|HLA-DO, encoded by the HLA-DOA and HLA-DOB genes, has been shown to function as a modulator of Ag presentation. DNA microarray comparisons between B cells wild-type and mutant for the master regulator of MHC class II transcription, class II transactivator (CIITA), identified HLA-DOA and HLA-DOB as being up-regulated by CIITA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | down-regulates
phosphorylation
|
CIITA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270173 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18245089 |
In this study we show that the extracellular signal-regulated kinases 1 and 2 (erk1/2) interact directly with ciita, targeting serine residues in the amino terminus of the protein, including serine 288. These data suggest a model whereby erk1/2-mediated phosphorylation of ciita down-regulates ciita activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity
transcriptional regulation
|
CIITA |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255752 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9551976 |
A role for STAT1 in regulation of the CIITA promoter is shown by the rescue of IFN-gamma induction by expression of STAT1 in STAT1-defective U3A cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DRA |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254008 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 10886240 |
These results indicate that impaired up-regulation of HLA-DR in response to IFN-gamma results from insufficient induction of CIITA, but not from the signal from IFN-gamma receptor to the nucleus. The abnormal regulation of HLA-DR expression caused by impaired induction of CIITA may affect CD4+ T cell development in thymoma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates activity
binding
|
RFX5 |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240980 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 9177217 |
RFX5 can activate transcription only in cooperation with CIITA. RFX5 and CIITA associate to form a complex capable of activating transcription from class II major histocompatibility complex promoters. In this complex, promoter specificity is determined by the DNA binding domain of RFX5 and the general transcription apparatus is recruited by the acidic activation domain of CIITA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF2 | up-regulates quantity by expression
transcriptional regulation
|
CIITA |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271681 |
|
|
|
|
| pmid |
sentence |
| 11464288 |
In addition to IRF-1, IRF-2, another member of the IRF family, also activates the human CIITA type IV promoter, and IRF-2 cooperates with IRF-1 to activate the promoter in transient transfection assays. |
|
| Publications: |
1 |
| + |
HDAC2 | down-regulates quantity by repression
deacetylation
|
CIITA |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254231 |
|
|
Homo sapiens |
Macrophage, Smooth Muscle Cell |
| pmid |
sentence |
| 19041327 |
We report that CIITA and histone deacetylase 2 (HDAC2) interact in smooth muscle cells and macrophages as assayed by co-immunoprecipitations. HDAC2 deacetylates CIITA whereas both the HDAC inhibitor trichostatin A (TSA) and over-expression of HDAC2 interfering RNA increase CIITA acetylation. HDAC2 down-regulates CIITA recruitment to target promoters as evidenced by chromatin immunoprecipitation assays, and suppresses MHC II activation and collagen repression mediated by CIITA in luciferase reporter assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DRB1 |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253976 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 10886240 |
These results indicate that impaired up-regulation of HLA-DR in response to IFN-gamma results from insufficient induction of CIITA, but not from the signal from IFN-gamma receptor to the nucleus. The abnormal regulation of HLA-DR expression caused by impaired induction of CIITA may affect CD4+ T cell development in thymoma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
CIITA |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249498 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19029990 |
STAT1 binds as a homodimer to cis elements known as gammaactivated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among others. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | down-regulates 
transcriptional regulation
|
IL4 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254499 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 10946277 |
We identified two domains of CIITA that interact with two distinct domains of CBP/p300 that are also recognized by NF-AT. CIITA mutants that retain the ability to interact with CBP/p300 are sufficient to inhibit NF-AT-mediated IL-4 gene expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | down-regulates
phosphorylation
|
CIITA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270067 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18245089 |
In this study we show that the extracellular signal-regulated kinases 1 and 2 (erk1/2) interact directly with ciita, targeting serine residues in the amino terminus of the protein, including serine 288. These data suggest a model whereby erk1/2-mediated phosphorylation of ciita down-regulates ciita activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DPB1 |
0.512 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254006 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11889043 |
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation|We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DMB |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254010 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11889043 |
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation|We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254014 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 9300700 |
The class II transactivator (CIITA) is a highly specific transcription factor that activates only genes known to be involved in the class II MHC processing pathway, including class II MHC, invariant chain, and HLA-DMA/B genes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-F |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254018 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11137213 |
HLA-E is inducible by CIITA through the SXY regulatory module. HLA-F is inducible by NF-kappaB through the kappaB1 site of enhancer A, is responsive to IFN-gamma through the ISRE, and is inducible by CIITA |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-A |
0.522 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254020 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 10329350 |
Transfection of CIITA in JEG-3 cells also upregulated functional HLA-B and HLA-C expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DQB1 |
0.519 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254017 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11332992 |
The class II transactivator (CIITA) regulates expression of the classical and non-classical MHC class II genes, HLA-DR, -DP, -DQ and -DM, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates
transcriptional regulation
|
CIITA |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256249 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21576360 |
When IFN-γ binds to its receptor, the receptor-associated protein tyrosine kinases Janus kinase I (JAK1) and JAK2 are activated (37). This leads to the phosphorylation of STAT1, which then dimerizes, translocates to the nucleus, and activates its target promoters, including the pIV promoter of Ciita |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DMA |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254004 |
|
|
|
|
| pmid |
sentence |
| 9300700 |
The class II transactivator (CIITA) is a highly specific transcription factor that activates only genes known to be involved in the class II MHC processing pathway, including class II MHC, invariant chain, and HLA-DMA/B genes. |
|
| Publications: |
1 |
| + |
PRDM1 | down-regulates quantity by repression
transcriptional regulation
|
CIITA |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99116 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 12626569 |
The positive regulatory domain i binding factor 1 (prdi-bf1 or blimp-1) protein represses the transcription of specific target genes, including c-myc, the mhc class ii trans-activator, pax-5, and cd23b |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DOB |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254015 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11823510 |
Class II transactivator is required for maximal expression of HLA-DOB in B cells|HLA-DO, encoded by the HLA-DOA and HLA-DOB genes, has been shown to function as a modulator of Ag presentation. DNA microarray comparisons between B cells wild-type and mutant for the master regulator of MHC class II transcription, class II transactivator (CIITA), identified HLA-DOA and HLA-DOB as being up-regulated by CIITA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DRB4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254012 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 10886240 |
These results indicate that impaired up-regulation of HLA-DR in response to IFN-gamma results from insufficient induction of CIITA, but not from the signal from IFN-gamma receptor to the nucleus. The abnormal regulation of HLA-DR expression caused by impaired induction of CIITA may affect CD4+ T cell development in thymoma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA |
transcriptional regulation
|
HLA-G |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254021 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11137218 |
The X1 box is the binding site for the ubiquitous RFX complex consisting of three subunits; the X2 box is bound by the X2BP/ATF/CREB family factors. The basic S-X-Y regulatory module interacts with CIITA, which is expressed constitutively in APCs, but may be inducible in others cell types by IFN-gamma|We propose that the X region in the HLA-G gene promoter might participate to the combination of factors which play a role in HLA-G gene activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DRB3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254011 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10886240 |
These results indicate that impaired up-regulation of HLA-DR in response to IFN-gamma results from insufficient induction of CIITA, but not from the signal from IFN-gamma receptor to the nucleus. The abnormal regulation of HLA-DR expression caused by impaired induction of CIITA may affect CD4+ T cell development in thymoma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | down-regulates
binding
|
MYOG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255111 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28163303 |
During early stages of myogenesis, CIITA binds directly to myogenin (MYOG) and inactivates it, preventing MYOG-mediated induction of myogenic genes that are required for muscle differentiation and function |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DRB5 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254013 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 10886240 |
These results indicate that impaired up-regulation of HLA-DR in response to IFN-gamma results from insufficient induction of CIITA, but not from the signal from IFN-gamma receptor to the nucleus. The abnormal regulation of HLA-DR expression caused by impaired induction of CIITA may affect CD4+ T cell development in thymoma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-E |
0.498 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254019 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11137213 |
HLA-E is inducible by CIITA through the SXY regulatory module. HLA-F is inducible by NF-kappaB through the kappaB1 site of enhancer A, is responsive to IFN-gamma through the ISRE, and is inducible by CIITA |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | down-regulates quantity by repression
transcriptional regulation
|
S100A4 |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253776 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17143014 |
IFN-gamma represses S100A4 promoter activity through induction of the class II transactivator (CIITA). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-C |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253775 |
|
|
Homo sapiens |
JEG-3 Cell |
| pmid |
sentence |
| 11053628 |
Transfection of CIITA in JEG-3 cells also upregulated functional HLA-B and HLA-C expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CIITA
- 
- 