| Name | TTK |
| ID | P33981 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 525-791 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TTK | BUB1 | Thr461 | SKVQPSPtVHTKEAL | phosphorylation up-regulates activity | 28072388 | SIGNOR-278255 |
| TTK | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates | 15618221 | SIGNOR-132665 |
| TTK | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181064 |
| TTK | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates | 19332559 | SIGNOR-184931 |
| TTK | MAPT | – | phosphorylation up-regulates activity | 11257498 | SIGNOR-279132 | |
| TTK | NT5E | – | phosphorylation up-regulates activity | 29502948 | SIGNOR-280157 | |
| TTK | MAP4 | Ser928 | SRLATNTsAPDLKNV | phosphorylation down-regulates quantity by destabilization | 31253867 | SIGNOR-277458 |
| TTK | MAP4 | Thr927 | LSRLATNtSAPDLKN | phosphorylation down-regulates quantity by destabilization | 31253867 | SIGNOR-277462 |
| TTK | TTK | Thr675 | ANQMQPDtTSVVKDS | phosphorylation down-regulates | 18680479 | SIGNOR-179904 |
| TTK | TTK | Thr806 | NQMAKGTtEEMKYVL | phosphorylation down-regulates | 18680479 | SIGNOR-179908 |
| TTK | TTK | Ser582 | LNKLQQHsDKIIRLY | phosphorylation up-regulates | 18680479 | SIGNOR-179896 |
| TTK | TTK | Ser742 | QQIINQIsKLHAIID | phosphorylation up-regulates | 18680479 | SIGNOR-179900 |
| TTK | TTK | Ser677 | QMQPDTTsVVKDSQV | phosphorylation up-regulates | 19120698 | SIGNOR-183022 |
| TTK | TTK | Thr676 | NQMQPDTtSVVKDSQ | phosphorylation up-regulates | 19120698 | SIGNOR-183026 |
| TTK | TTK | Thr686 | VKDSQVGtVNYMPPE | phosphorylation up-regulates | 19120698 | SIGNOR-183030 |
| TTK | TTK | Ser214 | TVLTAQEsFSGSLGH | phosphorylation up-regulates activity | 26119734 | SIGNOR-276217 |
| TTK | TTK | Ser321 | SKPSGNDsCELRNLK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276213 |
| TTK | TTK | Ser362 | TLKNKTEsSLLAKLE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276201 |
| TTK | TTK | Ser363 | LKNKTESsLLAKLEE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276209 |
| TTK | TTK | Ser37 | EDLTDELsLNKISAD | phosphorylation up-regulates activity | 26119734 | SIGNOR-276207 |
| TTK | TTK | Thr12 | DLSGRELtIDSIMNK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276203 |
| TTK | TTK | Thr33 | KFKNEDLtDELSLNK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276205 |
| TTK | TTK | Thr371 | LLAKLEEtKEYQEPE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276211 |
| TTK | TTK | Thr564 | LEEADNQtLDSYRNE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276215 |
| TTK | HSPA9 | Ser65 | IDLGTTNsCVAVMEG | phosphorylation up-regulates | 17573779 | SIGNOR-156181 |
| TTK | HSPA9 | Thr62 | VVGIDLGtTNSCVAV | phosphorylation up-regulates | 17573779 | SIGNOR-156185 |
| TTK | BLM | – | phosphorylation up-regulates activity | 23700430 | SIGNOR-280156 | |
| TTK | MDM2 | Thr306 | LADYWKCtSCNEMNP | phosphorylation up-regulates activity | 26531827 | SIGNOR-279315 |
| TTK | MDM2 | Thr4 | tNMSVPTD | phosphorylation up-regulates activity | 26531827 | SIGNOR-279314 |
| TTK | CENPE | – | phosphorylation up-regulates activity | 18342609 | SIGNOR-278999 | |
| TTK | MAD2L1 | – | phosphorylation up-regulates activity | 18541701 | SIGNOR-252036 | |
| TTK | CDCA8 | – | phosphorylation up-regulates | 18243099 | SIGNOR-160604 | |
| TTK | CDCA8 | Thr169 | KRSSRANtVTPAVGR | phosphorylation up-regulates | 19530738 | SIGNOR-186143 |
| TTK | CDCA8 | Thr230 | DSKEIFLtVPVGGGE | phosphorylation up-regulates | 19530738 | SIGNOR-186147 |
| TTK | CDCA8 | Thr88 | QALEEAAtADLDITE | phosphorylation up-regulates | 19530738 | SIGNOR-186151 |
| TTK | CDCA8 | Thr94 | ATADLDItEINKLTA | phosphorylation up-regulates | 19530738 | SIGNOR-186155 |
| TTK | ARHGEF17 | – | phosphorylation down-regulates activity | 26953350 | SIGNOR-279352 | |
| TTK | USP16 | Ser415 | VEDEDQDsEEEKDND | phosphorylation down-regulates quantity by destabilization | 28380042 | SIGNOR-277350 |
| TTK | USP16 | Thr554 | EVLTSSPtRNLNGAY | phosphorylation down-regulates quantity by destabilization | 28380042 | SIGNOR-277351 |
| TTK | MAD1L1 | – | phosphorylation up-regulates activity | 18541701 | SIGNOR-279000 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TTK | phosphorylation up-regulates → | BUB1 PThr461 | phosphorylation up-regulates → | BUB1 | 28072388 | SIGNOR-278255 |
| TTK | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 15618221 | SIGNOR-132665 |
| TTK | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181064 |
| TTK | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 19332559 | SIGNOR-184931 |
| TTK | phosphorylation up-regulates → | MAP4 PSer928 | phosphorylation down-regulates ⊣ | MAP4 | 31253867 | SIGNOR-277458 |
| TTK | phosphorylation up-regulates → | MAP4 PThr927 | phosphorylation down-regulates ⊣ | MAP4 | 31253867 | SIGNOR-277462 |
| TTK | phosphorylation up-regulates → | TTK PThr675 | phosphorylation down-regulates ⊣ | TTK | 18680479 | SIGNOR-179904 |
| TTK | phosphorylation up-regulates → | TTK PThr806 | phosphorylation down-regulates ⊣ | TTK | 18680479 | SIGNOR-179908 |
| TTK | phosphorylation up-regulates → | TTK PSer582 | phosphorylation up-regulates → | TTK | 18680479 | SIGNOR-179896 |
| TTK | phosphorylation up-regulates → | TTK PSer742 | phosphorylation up-regulates → | TTK | 18680479 | SIGNOR-179900 |
| TTK | phosphorylation up-regulates → | TTK PSer677 | phosphorylation up-regulates → | TTK | 19120698 | SIGNOR-183022 |
| TTK | phosphorylation up-regulates → | TTK PThr676 | phosphorylation up-regulates → | TTK | 19120698 | SIGNOR-183026 |
| TTK | phosphorylation up-regulates → | TTK PThr686 | phosphorylation up-regulates → | TTK | 19120698 | SIGNOR-183030 |
| TTK | phosphorylation up-regulates → | TTK PSer214 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276217 |
| TTK | phosphorylation up-regulates → | TTK PSer321 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276213 |
| TTK | phosphorylation up-regulates → | TTK PSer362 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276201 |
| TTK | phosphorylation up-regulates → | TTK PSer363 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276209 |
| TTK | phosphorylation up-regulates → | TTK PSer37 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276207 |
| TTK | phosphorylation up-regulates → | TTK PThr12 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276203 |
| TTK | phosphorylation up-regulates → | TTK PThr33 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276205 |
| TTK | phosphorylation up-regulates → | TTK PThr371 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276211 |
| TTK | phosphorylation up-regulates → | TTK PThr564 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276215 |
| TTK | phosphorylation up-regulates → | HSPA9 PSer65 | phosphorylation up-regulates → | HSPA9 | 17573779 | SIGNOR-156181 |
| TTK | phosphorylation up-regulates → | HSPA9 PThr62 | phosphorylation up-regulates → | HSPA9 | 17573779 | SIGNOR-156185 |
| TTK | phosphorylation up-regulates → | MDM2 PThr306 | phosphorylation up-regulates → | MDM2 | 26531827 | SIGNOR-279315 |
| TTK | phosphorylation up-regulates → | MDM2 PThr4 | phosphorylation up-regulates → | MDM2 | 26531827 | SIGNOR-279314 |
| TTK | phosphorylation up-regulates → | CDCA8 PThr169 | phosphorylation up-regulates → | CDCA8 | 19530738 | SIGNOR-186143 |
| TTK | phosphorylation up-regulates → | CDCA8 PThr230 | phosphorylation up-regulates → | CDCA8 | 19530738 | SIGNOR-186147 |
| TTK | phosphorylation up-regulates → | CDCA8 PThr88 | phosphorylation up-regulates → | CDCA8 | 19530738 | SIGNOR-186151 |
| TTK | phosphorylation up-regulates → | CDCA8 PThr94 | phosphorylation up-regulates → | CDCA8 | 19530738 | SIGNOR-186155 |
| TTK | phosphorylation up-regulates → | USP16 PSer415 | phosphorylation down-regulates ⊣ | USP16 | 28380042 | SIGNOR-277350 |
| TTK | phosphorylation up-regulates → | USP16 PThr554 | phosphorylation down-regulates ⊣ | USP16 | 28380042 | SIGNOR-277351 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TTK | phosphorylation → up-regulates activity | BUB1 | SIGNOR-278255 |
| TTK | phosphorylation → up-regulates | CHEK2 | SIGNOR-132665 |
| TTK | phosphorylation down-regulates | ABL1 | SIGNOR-181064 |
| TTK | phosphorylation → up-regulates | TP53 | SIGNOR-184931 |
| TTK | phosphorylation → up-regulates activity | MAPT | SIGNOR-279132 |
| TTK | phosphorylation → up-regulates activity | NT5E | SIGNOR-280157 |
| TTK | phosphorylation down-regulates quantity by destabilization | MAP4 | SIGNOR-277458 |
| TTK | phosphorylation down-regulates quantity by destabilization | MAP4 | SIGNOR-277462 |
| TTK | phosphorylation down-regulates | TTK | SIGNOR-179904 |
| TTK | phosphorylation down-regulates | TTK | SIGNOR-179908 |
| TTK | phosphorylation → up-regulates | TTK | SIGNOR-179896 |
| TTK | phosphorylation → up-regulates | TTK | SIGNOR-179900 |
| TTK | phosphorylation → up-regulates | TTK | SIGNOR-183022 |
| TTK | phosphorylation → up-regulates | TTK | SIGNOR-183026 |
| TTK | phosphorylation → up-regulates | TTK | SIGNOR-183030 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276217 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276213 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276201 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276209 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276207 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276203 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276205 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276211 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276215 |
| TTK | phosphorylation → up-regulates | HSPA9 | SIGNOR-156181 |
| TTK | phosphorylation → up-regulates | HSPA9 | SIGNOR-156185 |
| TTK | phosphorylation → up-regulates activity | BLM | SIGNOR-280156 |
| TTK | phosphorylation → up-regulates activity | MDM2 | SIGNOR-279315 |
| TTK | phosphorylation → up-regulates activity | MDM2 | SIGNOR-279314 |
| TTK | phosphorylation → up-regulates activity | CENPE | SIGNOR-278999 |
| TTK | phosphorylation → up-regulates activity | MAD2L1 | SIGNOR-252036 |
| TTK | phosphorylation → up-regulates | CDCA8 | SIGNOR-160604 |
| TTK | phosphorylation → up-regulates | CDCA8 | SIGNOR-186143 |
| TTK | phosphorylation → up-regulates | CDCA8 | SIGNOR-186147 |
| TTK | phosphorylation → up-regulates | CDCA8 | SIGNOR-186151 |
| TTK | phosphorylation → up-regulates | CDCA8 | SIGNOR-186155 |
| TTK | phosphorylation → down-regulates activity | ARHGEF17 | SIGNOR-279352 |
| TTK | phosphorylation down-regulates quantity by destabilization | USP16 | SIGNOR-277350 |
| TTK | phosphorylation down-regulates quantity by destabilization | USP16 | SIGNOR-277351 |
| TTK | phosphorylation → up-regulates activity | MAD1L1 | SIGNOR-279000 |