Summary

Name TTK
Full Name Dual specificity protein kinase TTK
Synonyms Phosphotyrosine picked threonine-protein kinase, PYT | MPS1, MPS1L1
Primary ID P33981
Links - -
Type protein
Relations 23
Inhibitors 1124329-14-1
Function Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation TTK
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HSPA9 0.72
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDCA8 0.96
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TTK 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TTK 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TTK
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHEK2 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.23
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TTK
Publications: 1
+ down-regulates img/direct_inhibition.png chemical inhibition TTK
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAD2L1
Publications: 1
+ up-regulates img/indirect-activation.png unknown TTK
Publications: 1 Organism: Homo Sapiens