| Name | TTK |
| ID | P33981 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 525-791 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | TTK | Thr458 | CKTPSSNtLDDYMSC | phosphorylation up-regulates activity | 26119734 | SIGNOR-276222 |
| PLK1 | TTK | Ser363 | LKNKTESsLLAKLEE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276208 |
| TTK | TTK | Thr12 | DLSGRELtIDSIMNK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276203 |
| PLK1 | TTK | Thr371 | LLAKLEEtKEYQEPE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276210 |
| TTK | TTK | Ser677 | QMQPDTTsVVKDSQV | phosphorylation up-regulates | 19120698 | SIGNOR-183022 |
| PLK1 | TTK | Ser333 | NLKSVQNsHFKEPLV | phosphorylation up-regulates activity | 26119734 | SIGNOR-276197 |
| PLK1 | TTK | Thr33 | KFKNEDLtDELSLNK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276204 |
| PLK1 | TTK | Ser321 | SKPSGNDsCELRNLK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276212 |
| CDK2 | TTK | Thr468 | DYMSCFRtPVVKNDF | phosphorylation up-regulates quantity by stabilization | 20861309 | SIGNOR-279398 |
| TTK | TTK | Thr676 | NQMQPDTtSVVKDSQ | phosphorylation up-regulates | 19120698 | SIGNOR-183026 |
| PLK1 | TTK | Thr210 | LSASTVLtAQESFSG | phosphorylation up-regulates activity | 26119734 | SIGNOR-276219 |
| TTK | TTK | Ser362 | TLKNKTEsSLLAKLE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276201 |
| PLK1 | TTK | Ser291 | CDVKTDDsVVPCFMK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276199 |
| TTK | TTK | Thr371 | LLAKLEEtKEYQEPE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276211 |
| TTK | TTK | Thr686 | VKDSQVGtVNYMPPE | phosphorylation up-regulates | 19120698 | SIGNOR-183030 |
| TTK | TTK | Ser582 | LNKLQQHsDKIIRLY | phosphorylation up-regulates | 18680479 | SIGNOR-179896 |
| CHEK2 | TTK | Thr288 | SPDCDVKtDDSVVPC | phosphorylation up-regulates | 19151762 | SIGNOR-242665 |
| PLK1 | TTK | Thr594 | RLYDYEItDQYIYMV | phosphorylation up-regulates activity | 26119734 | SIGNOR-276221 |
| TTK | TTK | Thr806 | NQMAKGTtEEMKYVL | phosphorylation down-regulates | 18680479 | SIGNOR-179908 |
| TTK | TTK | Ser363 | LKNKTESsLLAKLEE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276209 |
| PLK1 | TTK | Ser362 | TLKNKTEsSLLAKLE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276200 |
| TTK | TTK | Thr675 | ANQMQPDtTSVVKDS | phosphorylation down-regulates | 18680479 | SIGNOR-179904 |
| PLK1 | TTK | Ser345 | PLVSDEKsSELIITD | phosphorylation up-regulates activity | 26119734 | SIGNOR-276198 |
| PLK1 | TTK | Ser37 | EDLTDELsLNKISAD | phosphorylation up-regulates activity | 26119734 | SIGNOR-276206 |
| TTK | TTK | Ser742 | QQIINQIsKLHAIID | phosphorylation up-regulates | 18680479 | SIGNOR-179900 |
| PLK1 | TTK | Thr564 | LEEADNQtLDSYRNE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276214 |
| PLK1 | TTK | – | phosphorylation up-regulates activity | 26119734 | SIGNOR-278246 | |
| TTK | TTK | Ser321 | SKPSGNDsCELRNLK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276213 |
| PLK1 | TTK | Thr12 | DLSGRELtIDSIMNK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276202 |
| PLK1 | TTK | Ser108 | DKYGQNEsFARIQVR | phosphorylation up-regulates activity | 26119734 | SIGNOR-276220 |
| PLK1 | TTK | Thr46 | NKISADTtDNSGTVN | phosphorylation up-regulates activity | 26119734 | SIGNOR-276218 |
| PLK1 | TTK | Ser214 | TVLTAQEsFSGSLGH | phosphorylation up-regulates activity | 26119734 | SIGNOR-276216 |
| TTK | TTK | Ser214 | TVLTAQEsFSGSLGH | phosphorylation up-regulates activity | 26119734 | SIGNOR-276217 |
| TTK | TTK | Ser37 | EDLTDELsLNKISAD | phosphorylation up-regulates activity | 26119734 | SIGNOR-276207 |
| TTK | TTK | Thr33 | KFKNEDLtDELSLNK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276205 |
| CHEK2 | TTK | Thr288 | SPDCDVKtDDSVVPC | phosphorylation unknown | 19151762 | SIGNOR-183470 |
| TTK | TTK | Thr564 | LEEADNQtLDSYRNE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276215 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | TTK PThr458 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276222 |
| PLK1 | phosphorylation up-regulates → | TTK PSer363 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276208 |
| TTK | phosphorylation up-regulates → | TTK PThr12 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276203 |
| PLK1 | phosphorylation up-regulates → | TTK PThr371 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276210 |
| TTK | phosphorylation up-regulates → | TTK PSer677 | phosphorylation up-regulates → | TTK | 19120698 | SIGNOR-183022 |
| PLK1 | phosphorylation up-regulates → | TTK PSer333 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276197 |
| PLK1 | phosphorylation up-regulates → | TTK PThr33 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276204 |
| PLK1 | phosphorylation up-regulates → | TTK PSer321 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276212 |
| CDK2 | phosphorylation up-regulates → | TTK PThr468 | phosphorylation up-regulates → | TTK | 20861309 | SIGNOR-279398 |
| TTK | phosphorylation up-regulates → | TTK PThr676 | phosphorylation up-regulates → | TTK | 19120698 | SIGNOR-183026 |
| PLK1 | phosphorylation up-regulates → | TTK PThr210 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276219 |
| TTK | phosphorylation up-regulates → | TTK PSer362 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276201 |
| PLK1 | phosphorylation up-regulates → | TTK PSer291 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276199 |
| TTK | phosphorylation up-regulates → | TTK PThr371 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276211 |
| TTK | phosphorylation up-regulates → | TTK PThr686 | phosphorylation up-regulates → | TTK | 19120698 | SIGNOR-183030 |
| TTK | phosphorylation up-regulates → | TTK PSer582 | phosphorylation up-regulates → | TTK | 18680479 | SIGNOR-179896 |
| CHEK2 | phosphorylation up-regulates → | TTK PThr288 | phosphorylation up-regulates → | TTK | 19151762 | SIGNOR-242665 |
| PLK1 | phosphorylation up-regulates → | TTK PThr594 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276221 |
| TTK | phosphorylation up-regulates → | TTK PThr806 | phosphorylation down-regulates ⊣ | TTK | 18680479 | SIGNOR-179908 |
| TTK | phosphorylation up-regulates → | TTK PSer363 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276209 |
| PLK1 | phosphorylation up-regulates → | TTK PSer362 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276200 |
| TTK | phosphorylation up-regulates → | TTK PThr675 | phosphorylation down-regulates ⊣ | TTK | 18680479 | SIGNOR-179904 |
| PLK1 | phosphorylation up-regulates → | TTK PSer345 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276198 |
| PLK1 | phosphorylation up-regulates → | TTK PSer37 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276206 |
| TTK | phosphorylation up-regulates → | TTK PSer742 | phosphorylation up-regulates → | TTK | 18680479 | SIGNOR-179900 |
| PLK1 | phosphorylation up-regulates → | TTK PThr564 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276214 |
| TTK | phosphorylation up-regulates → | TTK PSer321 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276213 |
| PLK1 | phosphorylation up-regulates → | TTK PThr12 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276202 |
| PLK1 | phosphorylation up-regulates → | TTK PSer108 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276220 |
| PLK1 | phosphorylation up-regulates → | TTK PThr46 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276218 |
| PLK1 | phosphorylation up-regulates → | TTK PSer214 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276216 |
| TTK | phosphorylation up-regulates → | TTK PSer214 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276217 |
| TTK | phosphorylation up-regulates → | TTK PSer37 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276207 |
| TTK | phosphorylation up-regulates → | TTK PThr33 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276205 |
| CHEK2 | phosphorylation up-regulates → | TTK PThr288 | phosphorylation down-regulates ⊣ | TTK | 19151762 | SIGNOR-183470 |
| TTK | phosphorylation up-regulates → | TTK PThr564 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276215 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276222 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276208 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276203 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276210 |
| TTK | phosphorylation → up-regulates | TTK | SIGNOR-183022 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276197 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276204 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276212 |
| CDK2 | phosphorylation → up-regulates quantity by stabilization | TTK | SIGNOR-279398 |
| TTK | phosphorylation → up-regulates | TTK | SIGNOR-183026 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276219 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276201 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276199 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276211 |
| TTK | phosphorylation → up-regulates | TTK | SIGNOR-183030 |
| TTK | phosphorylation → up-regulates | TTK | SIGNOR-179896 |
| CHEK2 | phosphorylation → up-regulates | TTK | SIGNOR-242665 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276221 |
| TTK | phosphorylation down-regulates | TTK | SIGNOR-179908 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276209 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276200 |
| TTK | phosphorylation down-regulates | TTK | SIGNOR-179904 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276198 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276206 |
| TTK | phosphorylation → up-regulates | TTK | SIGNOR-179900 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276214 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-278246 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276213 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276202 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276220 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276218 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276216 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276217 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276207 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276205 |
| CHEK2 | phosphorylation → unknown | TTK | SIGNOR-183470 |
| TTK | phosphorylation → up-regulates activity | TTK | SIGNOR-276215 |