| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | TTK | Thr288 | SPDCDVKtDDSVVPC | phosphorylation unknown | 19151762 | SIGNOR-183470 |
| CHEK2 | TTK | Thr288 | SPDCDVKtDDSVVPC | phosphorylation up-regulates | 19151762 | SIGNOR-242665 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | TTK PThr288 | phosphorylation down-regulates ⊣ | TTK | 19151762 | SIGNOR-183470 |
| CHEK2 | phosphorylation up-regulates → | TTK PThr288 | phosphorylation up-regulates → | TTK | 19151762 | SIGNOR-242665 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK2 | phosphorylation → unknown | TTK | SIGNOR-183470 |
| CHEK2 | phosphorylation → up-regulates | TTK | SIGNOR-242665 |
