| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | MCM4 | Ser54 | ELQPMPTsPGVDLQS | phosphorylation down-regulates activity | 12714602 | SIGNOR-100885 |
| CDK1 | MCM4 | Thr19 | GSRRGRAtPAQTPRS | phosphorylation down-regulates activity | 12714602 | SIGNOR-100877 |
| CDK2 | MCM4 | Thr110 | PRSGVRGtPVRQRPD | phosphorylation down-regulates activity | 12714602 | SIGNOR-100889 |
| CyclinA2/CDK2 | MCM4 | Ser54 | ELQPMPTsPGVDLQS | phosphorylation down-regulates | 12714602 | SIGNOR-217348 |
| CDC7 | MCM4 | – | phosphorylation up-regulates | 21070963 | SIGNOR-169453 | |
| ATR | MCM4 | – | phosphorylation up-regulates | 21070963 | SIGNOR-169412 | |
| CyclinA2/CDK2 | MCM4 | Ser32 | RSEDARSsPSQRRRG | phosphorylation down-regulates | 12714602 | SIGNOR-217344 |
| CDK2 | MCM4 | Ser32 | RSEDARSsPSQRRRG | phosphorylation down-regulates activity | 12714602 | SIGNOR-100881 |
| CDK2 | MCM4 | Thr19 | GSRRGRAtPAQTPRS | phosphorylation down-regulates activity | 12714602 | SIGNOR-100893 |
| CyclinA2/CDK2 | MCM4 | Thr110 | PRSGVRGtPVRQRPD | phosphorylation down-regulates | 12714602 | SIGNOR-217352 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | MCM4 PSer54 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-100885 |
| CDK1 | phosphorylation up-regulates → | MCM4 PThr19 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-100877 |
| CDK2 | phosphorylation up-regulates → | MCM4 PThr110 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-100889 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MCM4 PSer54 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-217348 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MCM4 PSer32 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-217344 |
| CDK2 | phosphorylation up-regulates → | MCM4 PSer32 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-100881 |
| CDK2 | phosphorylation up-regulates → | MCM4 PThr19 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-100893 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MCM4 PThr110 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-217352 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → down-regulates activity | MCM4 | SIGNOR-100885 |
| CDK1 | phosphorylation → down-regulates activity | MCM4 | SIGNOR-100877 |
| CDK2 | phosphorylation → down-regulates activity | MCM4 | SIGNOR-100889 |
| CyclinA2/CDK2 | phosphorylation down-regulates | MCM4 | SIGNOR-217348 |
| CDC7 | phosphorylation → up-regulates | MCM4 | SIGNOR-169453 |
| ATR | phosphorylation → up-regulates | MCM4 | SIGNOR-169412 |
| CyclinA2/CDK2 | phosphorylation down-regulates | MCM4 | SIGNOR-217344 |
| CDK2 | phosphorylation → down-regulates activity | MCM4 | SIGNOR-100881 |
| CDK2 | phosphorylation → down-regulates activity | MCM4 | SIGNOR-100893 |
| CyclinA2/CDK2 | phosphorylation down-regulates | MCM4 | SIGNOR-217352 |
