Summary

Name MCM4
Full Name DNA replication licensing factor MCM4
Synonyms CDC21 homolog, P1-CDC21 | CDC21
Primary ID P33991
Links - -
Type protein
Relations 11
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation MCM4 0.757
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MCM4 0.685
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MCM4 0.614
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MCM 0.759
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCM4 0.714
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCM4 0.957
Publications: 1 Organism: Homo Sapiens