| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | MCM4 | Thr19 | GSRRGRAtPAQTPRS | phosphorylation down-regulates activity | 12714602 | SIGNOR-100893 |
| CDK1 | MCM4 | Thr19 | GSRRGRAtPAQTPRS | phosphorylation down-regulates activity | 12714602 | SIGNOR-100877 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | MCM4 PThr19 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-100893 |
| CDK1 | phosphorylation up-regulates → | MCM4 PThr19 | phosphorylation down-regulates ⊣ | MCM4 | 12714602 | SIGNOR-100877 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → down-regulates activity | MCM4 | SIGNOR-100893 |
| CDK1 | phosphorylation → down-regulates activity | MCM4 | SIGNOR-100877 |