| Name | GRK5 |
| ID | P34947 |
| Role | kinase |
| Enzymatic Domains |
RGS 53-171 PROSITE-ProRule
Protein kinase 186-448 PROSITE-ProRule
AGC-kinase C-terminal 449-514 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK5 | LRP6 | – | phosphorylation up-regulates | 2787365 | SIGNOR-23330 | |
| GRK5 | TP53 | Thr55 | DDIEQWFtEDPGPDE | phosphorylation down-regulates | 20124405 | SIGNOR-163707 |
| GRK5 | ADRB2 | Ser396 | GHQGTVPsDNIDSQG | phosphorylation unknown | 8662852 | SIGNOR-251195 |
| GRK5 | ADRB2 | Ser401 | VPSDNIDsQGRNCST | phosphorylation unknown | 8662852 | SIGNOR-251196 |
| GRK5 | ADRB2 | Ser407 | DSQGRNCsTNDSLL | phosphorylation unknown | 8662852 | SIGNOR-251197 |
| GRK5 | ADRB2 | Ser411 | RNCSTNDsLL | phosphorylation unknown | 8662852 | SIGNOR-251198 |
| GRK5 | ADRB2 | Thr384 | LCEDLPGtEDFVGHQ | phosphorylation unknown | 8662852 | SIGNOR-251199 |
| GRK5 | ADRB2 | Thr393 | DFVGHQGtVPSDNID | phosphorylation unknown | 8662852 | SIGNOR-251200 |
| GRK5 | NR3C2 | – | phosphorylation down-regulates | 32326036 | SIGNOR-278478 | |
| GRK5 | BDKRB2 | Ser366 | EPIQMENsMGTLRTS | phosphorylation down-regulates activity | 11517230 | SIGNOR-251210 |
| GRK5 | BDKRB2 | Ser373 | SMGTLRTsISVERQI | phosphorylation down-regulates activity | 11517230 | SIGNOR-251208 |
| GRK5 | BDKRB2 | Ser375 | GTLRTSIsVERQIHK | phosphorylation down-regulates activity | 11517230 | SIGNOR-251209 |
| GRK5 | NTSR1 | – | phosphorylation up-regulates activity | 26120872 | SIGNOR-278234 | |
| GRK5 | GRK5 | Ser484 | VLDIEQFsTVKGVNL | phosphorylation up-regulates activity | 8144599 | SIGNOR-251201 |
| GRK5 | GRK5 | Thr485 | LDIEQFStVKGVNLD | phosphorylation up-regulates activity | 8144599 | SIGNOR-251202 |
| GRK5 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 16957079 | SIGNOR-149372 |
| GRK5 | ST13 | Ser346 | AQNPANMsKYQSNPK | phosphorylation up-regulates activity | 21728385 | SIGNOR-262877 |
| GRK5 | CXCR4 | Ser339 | GKRGGHSsVSTESES | phosphorylation down-regulates quantity | 24632620 | SIGNOR-279740 |
| GRK5 | SNCB | Ser118 | LMEPEGEsYEDPPQE | phosphorylation down-regulates activity | 10852916 | SIGNOR-251203 |
| GRK5 | HDAC5 | – | phosphorylation down-regulates activity | 23658733 | SIGNOR-279045 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK5 | phosphorylation up-regulates → | TP53 PThr55 | phosphorylation down-regulates ⊣ | TP53 | 20124405 | SIGNOR-163707 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PSer396 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251195 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PSer401 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251196 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PSer407 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251197 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PSer411 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251198 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PThr384 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251199 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PThr393 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251200 |
| GRK5 | phosphorylation up-regulates → | BDKRB2 PSer366 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251210 |
| GRK5 | phosphorylation up-regulates → | BDKRB2 PSer373 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251208 |
| GRK5 | phosphorylation up-regulates → | BDKRB2 PSer375 | phosphorylation down-regulates ⊣ | BDKRB2 | 11517230 | SIGNOR-251209 |
| GRK5 | phosphorylation up-regulates → | GRK5 PSer484 | phosphorylation up-regulates → | GRK5 | 8144599 | SIGNOR-251201 |
| GRK5 | phosphorylation up-regulates → | GRK5 PThr485 | phosphorylation up-regulates → | GRK5 | 8144599 | SIGNOR-251202 |
| GRK5 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 16957079 | SIGNOR-149372 |
| GRK5 | phosphorylation up-regulates → | ST13 PSer346 | phosphorylation up-regulates → | ST13 | 21728385 | SIGNOR-262877 |
| GRK5 | phosphorylation up-regulates → | CXCR4 PSer339 | phosphorylation down-regulates ⊣ | CXCR4 | 24632620 | SIGNOR-279740 |
| GRK5 | phosphorylation up-regulates → | SNCB PSer118 | phosphorylation down-regulates ⊣ | SNCB | 10852916 | SIGNOR-251203 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK5 | phosphorylation → up-regulates | LRP6 | SIGNOR-23330 |
| GRK5 | phosphorylation down-regulates | TP53 | SIGNOR-163707 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251195 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251196 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251197 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251198 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251199 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251200 |
| GRK5 | phosphorylation down-regulates | NR3C2 | SIGNOR-278478 |
| GRK5 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251210 |
| GRK5 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251208 |
| GRK5 | phosphorylation → down-regulates activity | BDKRB2 | SIGNOR-251209 |
| GRK5 | phosphorylation → up-regulates activity | NTSR1 | SIGNOR-278234 |
| GRK5 | phosphorylation → up-regulates activity | GRK5 | SIGNOR-251201 |
| GRK5 | phosphorylation → up-regulates activity | GRK5 | SIGNOR-251202 |
| GRK5 | phosphorylation → down-regulates activity | SNCA | SIGNOR-149372 |
| GRK5 | phosphorylation → up-regulates activity | ST13 | SIGNOR-262877 |
| GRK5 | phosphorylation → down-regulates quantity | CXCR4 | SIGNOR-279740 |
| GRK5 | phosphorylation → down-regulates activity | SNCB | SIGNOR-251203 |
| GRK5 | phosphorylation → down-regulates activity | HDAC5 | SIGNOR-279045 |