Summary

Name GRK5
Full Name G protein-coupled receptor kinase 5
Synonyms G protein-coupled receptor kinase GRK5 | GPRK5
Primary ID P34947
Links - -
Type protein
Relations 16
Function Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation SNCB 0.326
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation SNCA 0.618
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ST13 0.274
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BDKRB2 0.461
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ADRB2 0.68
Publications: 6 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRK5 0.2
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.383
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.528
Publications: 1 Organism: Homo Sapiens