| + |
GRK5 | down-regulates activity 
phosphorylation
|
SNCB |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251203 |
Ser118 |
LMEPEGEsYEDPPQE |
in vitro |
|
| pmid |
sentence |
| 10852916 |
GRK5 prefers alpha-synuclein as a substrate. GRK-mediated phosphorylation inhibits synuclein's interaction with both phospholipids and PLD2. Mutation of Ser118 practically abolishes β-synuclein phosphorylation by both GRK2 and GRK5 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
GRK5 | down-regulates activity
phosphorylation
|
SNCA |
0.652 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149372 |
Ser129 |
NEAYEMPsEEGYQDY |
Homo sapiens |
|
| pmid |
sentence |
| 16957079 |
Grk5 phosphorylated ser-129 of alpha-synuclein at the plasma membrane and induced translocation of phosphorylated alpha-synuclein to the perikaryal area. Grk5-catalyzed phosphorylation also promoted the formation of soluble oligomers and aggregates of alpha-synuclein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK5 | down-regulates quantity
phosphorylation
|
CXCR4 |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279740 |
Ser339 |
GKRGGHSsVSTESES |
Homo sapiens |
|
| pmid |
sentence |
| 24632620 |
Conversely, GRK5 knock-down in cells with low WIP1 expression inhibited CXCR4 phosphorylation, increased cell membrane expression of CXCR4, and promoted medulloblastoma growth.|Transfection of GRK5 into D556-WIP1 cells increased Ser339 phosphorylation of CXCR4 and reduced proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK5 | up-regulates activity 
phosphorylation
|
ST13 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262877 |
Ser346 |
AQNPANMsKYQSNPK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21728385 |
An in vitro screen for novel GRK substrates revealed Hsp70 interacting protein (Hip) as a substrate. GRK5, but not GRK2, bound to and stoichiometrically phosphorylated Hip in vitro. The primary binding domain of GRK5 was mapped to residues 303-319 on Hip, while the major site of phosphorylation was identified to be Ser-346. GRK5 also bound to and phosphorylated Hip on Ser-346 in cells.we found that the phosphorylation of Ser-346 was required for proper agonist-induced internalization of the chemokine receptor CXCR4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK5 | down-regulates activity
phosphorylation
|
BDKRB2 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251210 |
Ser366 |
EPIQMENsMGTLRTS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11517230 |
Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GRKs may phosphorylate the B2R and that the various GRKs, even without apparent effect on total GPCR phosphorylation levels, may induce distinct phosphorylation patterns with possible functional consequences for receptor desensitization and sequestration. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251208 |
Ser373 |
SMGTLRTsISVERQI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11517230 |
Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GRKs may phosphorylate the B2R and that the various GRKs, even without apparent effect on total GPCR phosphorylation levels, may induce distinct phosphorylation patterns with possible functional consequences for receptor desensitization and sequestration. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251209 |
Ser375 |
GTLRTSIsVERQIHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11517230 |
Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GRKs may phosphorylate the B2R and that the various GRKs, even without apparent effect on total GPCR phosphorylation levels, may induce distinct phosphorylation patterns with possible functional consequences for receptor desensitization and sequestration. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
GRK5 | unknown
phosphorylation
|
ADRB2 |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251195 |
Ser396 |
GHQGTVPsDNIDSQG |
in vitro |
|
| pmid |
sentence |
| 8662852 |
we report the identification of the sites of GRK2- and GRK5-mediated beta2AR phosphorylation. six are phosphorylated by GRK5 (Thr-384, Thr-393, Ser-396, Ser-401, Ser-407, and Ser-411). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251196 |
Ser401 |
VPSDNIDsQGRNCST |
in vitro |
|
| pmid |
sentence |
| 8662852 |
we report the identification of the sites of GRK2- and GRK5-mediated beta2AR phosphorylation. six are phosphorylated by GRK5 (Thr-384, Thr-393, Ser-396, Ser-401, Ser-407, and Ser-411). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251197 |
Ser407 |
DSQGRNCsTNDSLL |
in vitro |
|
| pmid |
sentence |
| 8662852 |
we report the identification of the sites of GRK2- and GRK5-mediated beta2AR phosphorylation. six are phosphorylated by GRK5 (Thr-384, Thr-393, Ser-396, Ser-401, Ser-407, and Ser-411). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251198 |
Ser411 |
RNCSTNDsLL |
in vitro |
|
| pmid |
sentence |
| 8662852 |
we report the identification of the sites of GRK2- and GRK5-mediated beta2AR phosphorylation. six are phosphorylated by GRK5 (Thr-384, Thr-393, Ser-396, Ser-401, Ser-407, and Ser-411). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251199 |
Thr384 |
LCEDLPGtEDFVGHQ |
in vitro |
|
| pmid |
sentence |
| 8662852 |
we report the identification of the sites of GRK2- and GRK5-mediated beta2AR phosphorylation. six are phosphorylated by GRK5 (Thr-384, Thr-393, Ser-396, Ser-401, Ser-407, and Ser-411). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251200 |
Thr393 |
DFVGHQGtVPSDNID |
in vitro |
|
| pmid |
sentence |
| 8662852 |
we report the identification of the sites of GRK2- and GRK5-mediated beta2AR phosphorylation. six are phosphorylated by GRK5 (Thr-384, Thr-393, Ser-396, Ser-401, Ser-407, and Ser-411). |
|
| Publications: |
6 |
Organism: |
In Vitro |
| + |
GRK5 | up-regulates activity
phosphorylation
|
GRK5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251201 |
Ser484 |
VLDIEQFsTVKGVNL |
in vitro |
|
| pmid |
sentence |
| 8144599 |
Autophosphorylation of GRK5 occurs primarily at residues Ser-484 and Thr-485. Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251202 |
Thr485 |
LDIEQFStVKGVNLD |
in vitro |
|
| pmid |
sentence |
| 8144599 |
Autophosphorylation of GRK5 occurs primarily at residues Ser-484 and Thr-485. Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
GRK5 | down-regulates
phosphorylation
|
TP53 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163707 |
Thr55 |
DDIEQWFtEDPGPDE |
Homo sapiens |
|
| pmid |
sentence |
| 20124405 |
Grk5, but not grk2 or grk6, phosphorylates p53 at thr-55, which promotes the degradation of p53, leading to inhibition of p53-dependent apoptotic response to genotoxic damage. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK5 | down-regulates
phosphorylation
|
NR3C2 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278478 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32326036 |
We report that GRK5 phosphorylates and inhibits the cardiac MR whereas GRK2 phosphorylates and desensitizes GPER. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PDGFRB | up-regulates activity
phosphorylation
|
GRK5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279642 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19092051 |
Purified GRK5 was tyrosine-phosphorylated by the wild-type PDGFRbeta to a stoichiometry of 0.8 mol phosphate/mol GRK5, an extent approximately 5 times greater than observed with a Y857F PDGFRbeta mutant that fails to phosphorylate exogenous substrates but autophosphorylates and activates Src normally.|We conclude that GRK5 tyrosyl phosphorylation is required for the activation of GRK5 by the PDGFRbeta, but not by the beta(2)-adrenergic receptor, and that by activating GRK5, the PDGFRbeta triggers its own desensitization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK5 | down-regulates activity
phosphorylation
|
HDAC5 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279045 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23658733 |
GRK5 phosphorylates and promotes the nuclear export of the histone deacetylase, HDAC5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK5 | up-regulates activity
phosphorylation
|
NTSR1 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278234 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26120872 |
Here we report the unique phosphorylation\nof NTSR1 by GRK2 and GRK5, which belong to the GRK2 and GRK4 subfamilies,\nrespectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRK5 | up-regulates
phosphorylation
|
LRP6 |
0.57 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-23330 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2787365 |
we found that g protein-coupled receptor kinases 5 and 6 (grk5/6), traditionally known to phosphorylate and desensitize 7tm g protein-coupled receptors, directly phosphorylate the pppsp motifs on single transmembrane lrp6 and regulate wnt/lrp6 signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
GRK5
- 
- 