Entity Details

Name GRK5
ID P34947
Role substrate
Enzymatic Domains
RGS 53-171
PROSITE-ProRule
Protein kinase 186-448
PROSITE-ProRule
AGC-kinase C-terminal 449-514
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GRK5GRK5Thr485LDIEQFStVKGVNLDphosphorylation
up-regulates activity		8144599SIGNOR-251202
GRK5GRK5Ser484VLDIEQFsTVKGVNLphosphorylation
up-regulates activity		8144599SIGNOR-251201
PDGFRBGRK5–phosphorylation
up-regulates activity		19092051SIGNOR-279642
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GRK5phosphorylation
up-regulates
→
GRK5
PThr485		phosphorylation
up-regulates
→		GRK58144599SIGNOR-251202
GRK5phosphorylation
up-regulates
→
GRK5
PSer484		phosphorylation
up-regulates
→		GRK58144599SIGNOR-251201
Regulator Mechanism/Effect Target SIGNOR-ID
GRK5phosphorylation
→
up-regulates activity 		GRK5SIGNOR-251202
GRK5phosphorylation
→
up-regulates activity 		GRK5SIGNOR-251201
PDGFRBphosphorylation
→
up-regulates activity 		GRK5SIGNOR-279642