| Name | NF2 |
| ID | P35240 |
| Role | substrate |
| Enzymatic Domains |
FERM 22-311 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK | NF2 | – | phosphorylation down-regulates | 18071304 | SIGNOR-269976 | |
| TNIK | NF2 | Thr576 | GGSSKHNtIKKLTLQ | phosphorylation up-regulates activity | 33495197 | SIGNOR-278385 |
| PRKACA | NF2 | Ser10 | GAIASRMsFSSLKRK | phosphorylation up-regulates | 18071304 | SIGNOR-159840 |
| PAK2 | NF2 | Ser518 | DTDMKRLsMEIEKEK | phosphorylation down-regulates | 18071304 | SIGNOR-159768 |
| TNIK | NF2 | Ser13 | ASRMSFSsLKRKQPK | phosphorylation up-regulates activity | 33495197 | SIGNOR-278388 |
| PPP1CB | NF2 | Ser518 | DTDMKRLsMEIEKEK | dephosphorylation up-regulates | 18071304 | SIGNOR-159836 |
| TNIK | NF2 | Ser315 | MRRRKADsLEVQQMK | phosphorylation up-regulates activity | 33495197 | SIGNOR-278387 |
| PAK1 | NF2 | Ser518 | DTDMKRLsMEIEKEK | phosphorylation down-regulates | 18071304 | SIGNOR-159764 |
| TNIK | NF2 | Thr272 | SYSDKEFtIKPLDKK | phosphorylation up-regulates activity | 33495197 | SIGNOR-278386 |
| PRKCA | NF2 | – | phosphorylation down-regulates activity | 24481838 | SIGNOR-280081 | |
| PRKACA | NF2 | Ser518 | DTDMKRLsMEIEKEK | phosphorylation down-regulates | 18071304 | SIGNOR-159844 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TNIK | phosphorylation up-regulates → | NF2 PThr576 | phosphorylation up-regulates → | NF2 | 33495197 | SIGNOR-278385 |
| PRKACA | phosphorylation up-regulates → | NF2 PSer10 | phosphorylation up-regulates → | NF2 | 18071304 | SIGNOR-159840 |
| PAK2 | phosphorylation up-regulates → | NF2 PSer518 | phosphorylation down-regulates ⊣ | NF2 | 18071304 | SIGNOR-159768 |
| TNIK | phosphorylation up-regulates → | NF2 PSer13 | phosphorylation up-regulates → | NF2 | 33495197 | SIGNOR-278388 |
| PPP1CB | dephosphorylation down-regulates ⊣ | NF2 PSer518 | dephosphorylation down-regulates ⊣ | NF2 | 18071304 | SIGNOR-159836 |
| TNIK | phosphorylation up-regulates → | NF2 PSer315 | phosphorylation up-regulates → | NF2 | 33495197 | SIGNOR-278387 |
| PAK1 | phosphorylation up-regulates → | NF2 PSer518 | phosphorylation down-regulates ⊣ | NF2 | 18071304 | SIGNOR-159764 |
| TNIK | phosphorylation up-regulates → | NF2 PThr272 | phosphorylation up-regulates → | NF2 | 33495197 | SIGNOR-278386 |
| PRKACA | phosphorylation up-regulates → | NF2 PSer518 | phosphorylation down-regulates ⊣ | NF2 | 18071304 | SIGNOR-159844 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK | phosphorylation down-regulates | NF2 | SIGNOR-269976 |
| TNIK | phosphorylation → up-regulates activity | NF2 | SIGNOR-278385 |
| PRKACA | phosphorylation → up-regulates | NF2 | SIGNOR-159840 |
| PAK2 | phosphorylation down-regulates | NF2 | SIGNOR-159768 |
| TNIK | phosphorylation → up-regulates activity | NF2 | SIGNOR-278388 |
| PPP1CB | dephosphorylation → up-regulates | NF2 | SIGNOR-159836 |
| TNIK | phosphorylation → up-regulates activity | NF2 | SIGNOR-278387 |
| PAK1 | phosphorylation down-regulates | NF2 | SIGNOR-159764 |
| TNIK | phosphorylation → up-regulates activity | NF2 | SIGNOR-278386 |
| PRKCA | phosphorylation → down-regulates activity | NF2 | SIGNOR-280081 |
| PRKACA | phosphorylation down-regulates | NF2 | SIGNOR-159844 |