Summary

Name NF2
Full Name Merlin
Synonyms Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomerlin, Schwannomin | SCH
Primary ID P35240
Links - -
Type protein
Relations 7
Function Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation NF2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation NF2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LATS2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LATS1 0.28
Publications: 1 Organism: Homo Sapiens