| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK2 | NF2 | Ser518 | DTDMKRLsMEIEKEK | phosphorylation down-regulates | 18071304 | SIGNOR-159768 |
| PPP1CB | NF2 | Ser518 | DTDMKRLsMEIEKEK | dephosphorylation up-regulates | 18071304 | SIGNOR-159836 |
| PAK1 | NF2 | Ser518 | DTDMKRLsMEIEKEK | phosphorylation down-regulates | 18071304 | SIGNOR-159764 |
| PRKACA | NF2 | Ser518 | DTDMKRLsMEIEKEK | phosphorylation down-regulates | 18071304 | SIGNOR-159844 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK2 | phosphorylation up-regulates → | NF2 PSer518 | phosphorylation down-regulates ⊣ | NF2 | 18071304 | SIGNOR-159768 |
| PPP1CB | dephosphorylation down-regulates ⊣ | NF2 PSer518 | dephosphorylation down-regulates ⊣ | NF2 | 18071304 | SIGNOR-159836 |
| PAK1 | phosphorylation up-regulates → | NF2 PSer518 | phosphorylation down-regulates ⊣ | NF2 | 18071304 | SIGNOR-159764 |
| PRKACA | phosphorylation up-regulates → | NF2 PSer518 | phosphorylation down-regulates ⊣ | NF2 | 18071304 | SIGNOR-159844 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK2 | phosphorylation down-regulates | NF2 | SIGNOR-159768 |
| PPP1CB | dephosphorylation → up-regulates | NF2 | SIGNOR-159836 |
| PAK1 | phosphorylation down-regulates | NF2 | SIGNOR-159764 |
| PRKACA | phosphorylation down-regulates | NF2 | SIGNOR-159844 |
