| Name | IRS1 |
| ID | P35568 |
| Role | substrate |
| Enzymatic Domains |
PH 12-115 PROSITE-ProRule
IRS-type PTB 160-264 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KB1 | IRS1 | Ser639 | YMPMSPKsVSAPQQI | phosphorylation down-regulates quantity by destabilization | 18498745 | SIGNOR-236599 |
| GSK3B | IRS1 | – | phosphorylation down-regulates quantity by destabilization | 20466847 | SIGNOR-279183 | |
| IGF1R | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation up-regulates | 17827393 | SIGNOR-157746 |
| INSR | IRS1 | Tyr941 | EETGTEEyMKMDLGP | phosphorylation up-regulates activity | 7651388 | SIGNOR-235975 |
| MAPK8 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates quantity by destabilization | 12510059 | SIGNOR-236591 |
| INSR | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | phosphorylation up-regulates activity | 12220227 | SIGNOR-236725 |
| JAK1 | IRS1 | – | phosphorylation up-regulates activity | 9305869 | SIGNOR-251343 | |
| INSR | IRS1 | Tyr465 | GEEELSNyICMGGKG | phosphorylation up-regulates activity | 7651388 | SIGNOR-236713 |
| IKBKB | IRS1 | Ser341 | GTMSRPAsVDGSPVS | phosphorylation down-regulates activity | 12351658 | SIGNOR-251294 |
| MTOR | IRS1 | Ser639 | YMPMSPKsVSAPQQI | phosphorylation down-regulates activity | 11287630 | SIGNOR-106590 |
| PTPN11 | IRS1 | Tyr1179 | GLENGLNyIDLDLVK | dephosphorylation down-regulates | 7515062 | SIGNOR-27024 |
| MAPK8 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates | 18728222 | SIGNOR-180532 |
| IKBKB | IRS1 | Ser272 | RPRSKSQsSSNCSNP | phosphorylation down-regulates activity | 12351658 | SIGNOR-251290 |
| MTOR | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates activity | 11287630 | SIGNOR-106578 |
| CSNK2B | IRS1 | Ser99 | HFAIAADsEAEQDSW | phosphorylation unknown | 8349691 | SIGNOR-251074 |
| RPS6KB1 | IRS1 | Ser270 | EFRPRSKsQSSSNCS | phosphorylation down-regulates activity | 9312143 | SIGNOR-51216 |
| MAPK1 | IRS1 | Ser636 | SGDYMPMsPKSVSAP | phosphorylation down-regulates activity | 12510059 | SIGNOR-249407 |
| CSNK2B | IRS1 | Thr811 | ADDSSSStSSDSLGG | phosphorylation unknown | 8349691 | SIGNOR-251075 |
| PTEN | IRS1 | Ser307 | TRRSRTEsITATSPA | dephosphorylation down-regulates activity | 25645159 | SIGNOR-277078 |
| SIK2 | IRS1 | Ser794 | QHLRLSTsSGRLLYA | phosphorylation unknown | 12624099 | SIGNOR-99055 |
| MAPK3 | IRS1 | Ser636 | SGDYMPMsPKSVSAP | phosphorylation down-regulates activity | 12510059 | SIGNOR-249409 |
| PRKACA | IRS1 | Ser1100 | QGCRRRHsSETFSST | phosphorylation down-regulates quantity by destabilization | 17360977 | SIGNOR-235675 |
| INSR | IRS1 | Tyr612 | TLHTDDGyMPMSPGV | phosphorylation up-regulates activity | 7651388 | SIGNOR-236756 |
| RPS6KB1 | IRS1 | Ser639 | YMPMSPKsVSAPQQI | phosphorylation down-regulates activity | 15306821 | SIGNOR-127203 |
| MAPK9 | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates | 9335553 | SIGNOR-52696 |
| MAPK9 | IRS1 | Tyr612 | TLHTDDGyMPMSPGV | phosphorylation down-regulates | 14579029 | SIGNOR-118873 |
| MTOR | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 9335553 | SIGNOR-52700 |
| CSNK2A1 | IRS1 | Thr811 | ADDSSSStSSDSLGG | phosphorylation unknown | 8349691 | SIGNOR-250910 |
| RPS6KB1 | IRS1 | Ser527 | RFRKRTHsAGTSPTI | phosphorylation down-regulates quantity by destabilization | 18498745 | SIGNOR-236595 |
| PRKCA | IRS1 | Ser24 | GYLRKPKsMHKRFFV | phosphorylation down-regulates activity | 16574739 | SIGNOR-145398 |
| Gbeta | IRS1 | – | phosphorylation down-regulates activity | 12510059 | SIGNOR-269997 | |
| MAPK1 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates | 17242212 | SIGNOR-152418 |
| LTK | IRS1 | – | phosphorylation up-regulates | 9223670 | SIGNOR-49531 | |
| IGF1R | IRS1 | Tyr989 | VPSSRGDyMTMQMSC | phosphorylation up-regulates | 17827393 | SIGNOR-157758 |
| RPS6K | IRS1 | – | phosphorylation down-regulates quantity by destabilization | 21798082 | SIGNOR-252787 | |
| MAPK8 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 14579029 | SIGNOR-118857 |
| CSNK2B | IRS1 | Ser24 | GYLRKPKsMHKRFFV | phosphorylation unknown | 8349691 | SIGNOR-251072 |
| RPS6KB1 | IRS1 | Ser527 | RFRKRTHsAGTSPTI | phosphorylation down-regulates activity | 16914728 | SIGNOR-148903 |
| CSNK2A1 | IRS1 | Ser99 | HFAIAADsEAEQDSW | phosphorylation unknown | 8349691 | SIGNOR-250909 |
| PRKCZ | IRS1 | Ser1101 | GCRRRHSsETFSSTP | phosphorylation down-regulates quantity by destabilization | 17360977 | SIGNOR-236022 |
| MAPK8 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 12510059 | SIGNOR-96936 |
| CSNK2B | IRS1 | Ser330 | SFRVRASsDGEGTMS | phosphorylation unknown | 8349691 | SIGNOR-251073 |
| JNK | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates quantity by destabilization | 12510059 | SIGNOR-235777 |
| MAPK8 | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates | 14579029 | SIGNOR-118861 |
| RPS6KB1 | IRS1 | Ser636 | SGDYMPMsPKSVSAP | phosphorylation down-regulates activity | 15306821 | SIGNOR-127912 |
| MAPK9 | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation down-regulates | 14579029 | SIGNOR-118877 |
| PLK1 | IRS1 | Ser24 | GYLRKPKsMHKRFFV | phosphorylation down-regulates activity | 15849359 | SIGNOR-135688 |
| MAP2K7 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 17360977 | SIGNOR-217920 |
| PTPN11 | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | dephosphorylation down-regulates | 7515062 | SIGNOR-27028 |
| INSR | IRS1 | Tyr989 | VPSSRGDyMTMQMSC | phosphorylation up-regulates activity | 7651388 | SIGNOR-235979 |
| PRKCZ | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 15069075 | SIGNOR-236760 |
| RPS6KB1 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 15306821 | SIGNOR-127908 |
| PRKCZ | IRS1 | Ser323 | MVGGKPGsFRVRASS | phosphorylation down-regulates | 15069075 | SIGNOR-123738 |
| CSNK2A1 | IRS1 | Thr88 | KHLVALYtRDEHFAI | phosphorylation unknown | 8349691 | SIGNOR-250911 |
| SIK2 | IRS1 | Ser794 | QHLRLSTsSGRLLYA | phosphorylation unknown | 12624099 | SIGNOR-99059 |
| CSNK2A1 | IRS1 | Ser24 | GYLRKPKsMHKRFFV | phosphorylation unknown | 8349691 | SIGNOR-250907 |
| IGF1R | IRS1 | Tyr941 | EETGTEEyMKMDLGP | phosphorylation up-regulates | 17827393 | SIGNOR-157754 |
| IGF1R | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | phosphorylation up-regulates | 17827393 | SIGNOR-157750 |
| IKBKB | IRS1 | Ser531 | RTHSAGTsPTITHQK | phosphorylation down-regulates activity | 12351658 | SIGNOR-251297 |
| PRKCQ | IRS1 | Ser1101 | GCRRRHSsETFSSTP | phosphorylation down-regulates activity | 15364919 | SIGNOR-260906 |
| RPS6KA1 | IRS1 | – | phosphorylation down-regulates quantity by destabilization | 21798082 | SIGNOR-175687 | |
| MEK1/2 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 11160134 | SIGNOR-244784 |
| INSR | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation up-regulates activity | 7651388 | SIGNOR-236741 |
| IGF1R | IRS1 | Tyr1179 | GLENGLNyIDLDLVK | phosphorylation up-regulates | 17827393 | SIGNOR-157730 |
| IGF1R | IRS1 | – | phosphorylation up-regulates | 15829723 | SIGNOR-255104 | |
| IGF1R | IRS1 | – | phosphorylation up-regulates | 21798082 | SIGNOR-175665 | |
| MAPK3 | IRS1 | Ser616 | DDGYMPMsPGVAPVP | phosphorylation down-regulates activity | 15001544 | SIGNOR-123177 |
| IKBKB | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 12351658 | SIGNOR-251292 |
| MTOR | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 11287630 | SIGNOR-106574 |
| PRKACA | IRS1 | Ser1222 | ESSSTRRsSEDLSAY | phosphorylation down-regulates quantity by destabilization | 17360977 | SIGNOR-236729 |
| IGF1R | IRS1 | Tyr612 | TLHTDDGyMPMSPGV | phosphorylation up-regulates | 17827393 | SIGNOR-157742 |
| PRKCD | IRS1 | Ser323 | MVGGKPGsFRVRASS | phosphorylation down-regulates | 15069075 | SIGNOR-123734 |
| IGF1R | IRS1 | Tyr465 | GEEELSNyICMGGKG | phosphorylation up-regulates | 17827393 | SIGNOR-157738 |
| IKBKB | IRS1 | Ser274 | RSKSQSSsNCSNPIS | phosphorylation down-regulates activity | 12351658 | SIGNOR-251291 |
| MTOR | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 11287630 | SIGNOR-106570 |
| IKBKB | IRS1 | Ser268 | SDEFRPRsKSQSSSN | phosphorylation down-regulates activity | 12351658 | SIGNOR-251288 |
| PTPN11 | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | dephosphorylation down-regulates | 10660596 | SIGNOR-74860 |
| PTPN13 | IRS1 | – | dephosphorylation down-regulates activity | 17638892 | SIGNOR-277053 | |
| ERK1/2 | IRS1 | – | phosphorylation down-regulates activity | 12510059 | SIGNOR-270132 | |
| PRKCD | IRS1 | Ser616 | DDGYMPMsPGVAPVP | phosphorylation down-regulates activity | 15143153 | SIGNOR-124737 |
| IKBKB | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 12351658 | SIGNOR-251293 |
| MAPK9 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 14579029 | SIGNOR-118881 |
| PTPN11 | IRS1 | Tyr1179 | GLENGLNyIDLDLVK | dephosphorylation down-regulates | 10660596 | SIGNOR-74856 |
| MAPK8 | IRS1 | Ser636 | SGDYMPMsPKSVSAP | phosphorylation down-regulates activity | 12510059 | SIGNOR-96948 |
| MAP2K1 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 11160134 | SIGNOR-236611 |
| IKBKB | IRS1 | Ser270 | EFRPRSKsQSSSNCS | phosphorylation down-regulates activity | 12351658 | SIGNOR-251289 |
| IKBKB | IRS1 | Ser527 | RFRKRTHsAGTSPTI | phosphorylation down-regulates activity | 12351658 | SIGNOR-251296 |
| SIK2 | IRS1 | Ser794 | QHLRLSTsSGRLLYA | phosphorylation down-regulates quantity | 24841198 | SIGNOR-265745 |
| INSR | IRS1 | Tyr612 | TLHTDDGyMPMSPGV | phosphorylation up-regulates activity | 11416002 | SIGNOR-235971 |
| INSR | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation up-regulates activity | 11416002 | SIGNOR-236709 |
| CSNK2B | IRS1 | Thr88 | KHLVALYtRDEHFAI | phosphorylation unknown | 8349691 | SIGNOR-251076 |
| IKBKB | IRS1 | Ser345 | RPASVDGsPVSPSTN | phosphorylation down-regulates activity | 12351658 | SIGNOR-251295 |
| PRKCD | IRS1 | Ser1101 | GCRRRHSsETFSSTP | phosphorylation down-regulates activity | 15364919 | SIGNOR-249267 |
| INSR | IRS1 | Tyr1229 | SSEDLSAyASISFQK | phosphorylation up-regulates activity | 12220227 | SIGNOR-235983 |
| PRKCD | IRS1 | Ser323 | MVGGKPGsFRVRASS | phosphorylation down-regulates | 16611834 | SIGNOR-146105 |
| PRKACA | IRS1 | Ser1223 | SSSTRRSsEDLSAYA | phosphorylation down-regulates quantity by destabilization | 17360977 | SIGNOR-236603 |
| IL4R | IRS1 | – | phosphorylation up-regulates | 12704343 | SIGNOR-100768 | |
| DYRK1A | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation up-regulates quantity | 31723029 | SIGNOR-279520 |
| CSNK2A1 | IRS1 | Thr502 | TPGTGLGtSPALAGD | phosphorylation unknown | 8349691 | SIGNOR-250906 |
| IGF1R | IRS1 | Tyr1229 | SSEDLSAyASISFQK | phosphorylation up-regulates | 17827393 | SIGNOR-157734 |
| MTOR | IRS1 | Ser636 | SGDYMPMsPKSVSAP | phosphorylation down-regulates activity | 11287630 | SIGNOR-106586 |
| RPS6KB1 | IRS1 | Ser1101 | GCRRRHSsETFSSTP | phosphorylation down-regulates activity | 15306821 | SIGNOR-127904 |
| MTOR | IRS1 | Ser616 | DDGYMPMsPGVAPVP | phosphorylation down-regulates activity | 11287630 | SIGNOR-106582 |
| EIF2AK2 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 20685959 | SIGNOR-278310 |
| DYRK1A | IRS1 | Ser616 | DDGYMPMsPGVAPVP | phosphorylation up-regulates quantity | 31723029 | SIGNOR-279521 |
| CSNK2A1 | IRS1 | Ser330 | SFRVRASsDGEGTMS | phosphorylation unknown | 8349691 | SIGNOR-250908 |
| MAPK1 | IRS1 | Ser616 | DDGYMPMsPGVAPVP | phosphorylation down-regulates activity | 15001544 | SIGNOR-123173 |
| MAPK8 | IRS1 | Ser616 | DDGYMPMsPGVAPVP | phosphorylation down-regulates activity | 12510059 | SIGNOR-96944 |
| CSNK2B | IRS1 | Thr502 | TPGTGLGtSPALAGD | phosphorylation unknown | 8349691 | SIGNOR-251077 |
| MAPK8 | IRS1 | Ser315 | ITATSPAsMVGGKPG | phosphorylation down-regulates | 12510059 | SIGNOR-96940 |
| PTPN1 | IRS1 | – | dephosphorylation down-regulates | 10660596 | SIGNOR-74852 | |
| INSR | IRS1 | Tyr1229 | SSEDLSAyASISFQK | phosphorylation up-regulates activity | 7651388 | SIGNOR-236752 |
| INSR | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | phosphorylation up-regulates activity | 7651388 | SIGNOR-236745 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer639 | phosphorylation down-regulates ⊣ | IRS1 | 18498745 | SIGNOR-236599 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157746 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr941 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-235975 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-236591 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr896 | phosphorylation up-regulates → | IRS1 | 12220227 | SIGNOR-236725 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr465 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236713 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer341 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251294 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer639 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106590 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr1179 | dephosphorylation up-regulates → | IRS1 | 7515062 | SIGNOR-27024 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 18728222 | SIGNOR-180532 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer272 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251290 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106578 |
| CSNK2B | phosphorylation up-regulates → | IRS1 PSer99 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-251074 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer270 | phosphorylation down-regulates ⊣ | IRS1 | 9312143 | SIGNOR-51216 |
| MAPK1 | phosphorylation up-regulates → | IRS1 PSer636 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-249407 |
| CSNK2B | phosphorylation up-regulates → | IRS1 PThr811 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-251075 |
| PTEN | dephosphorylation down-regulates ⊣ | IRS1 PSer307 | dephosphorylation up-regulates → | IRS1 | 25645159 | SIGNOR-277078 |
| SIK2 | phosphorylation up-regulates → | IRS1 PSer794 | phosphorylation down-regulates ⊣ | IRS1 | 12624099 | SIGNOR-99055 |
| MAPK3 | phosphorylation up-regulates → | IRS1 PSer636 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-249409 |
| PRKACA | phosphorylation up-regulates → | IRS1 PSer1100 | phosphorylation down-regulates ⊣ | IRS1 | 17360977 | SIGNOR-235675 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr612 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236756 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer639 | phosphorylation down-regulates ⊣ | IRS1 | 15306821 | SIGNOR-127203 |
| MAPK9 | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 9335553 | SIGNOR-52696 |
| MAPK9 | phosphorylation up-regulates → | IRS1 PTyr612 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118873 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 9335553 | SIGNOR-52700 |
| CSNK2A1 | phosphorylation up-regulates → | IRS1 PThr811 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-250910 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer527 | phosphorylation down-regulates ⊣ | IRS1 | 18498745 | SIGNOR-236595 |
| PRKCA | phosphorylation up-regulates → | IRS1 PSer24 | phosphorylation down-regulates ⊣ | IRS1 | 16574739 | SIGNOR-145398 |
| MAPK1 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 17242212 | SIGNOR-152418 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr989 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157758 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118857 |
| CSNK2B | phosphorylation up-regulates → | IRS1 PSer24 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-251072 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer527 | phosphorylation down-regulates ⊣ | IRS1 | 16914728 | SIGNOR-148903 |
| CSNK2A1 | phosphorylation up-regulates → | IRS1 PSer99 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-250909 |
| PRKCZ | phosphorylation up-regulates → | IRS1 PSer1101 | phosphorylation down-regulates ⊣ | IRS1 | 17360977 | SIGNOR-236022 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-96936 |
| CSNK2B | phosphorylation up-regulates → | IRS1 PSer330 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-251073 |
| JNK | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-235777 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118861 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer636 | phosphorylation down-regulates ⊣ | IRS1 | 15306821 | SIGNOR-127912 |
| MAPK9 | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118877 |
| PLK1 | phosphorylation up-regulates → | IRS1 PSer24 | phosphorylation down-regulates ⊣ | IRS1 | 15849359 | SIGNOR-135688 |
| MAP2K7 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 17360977 | SIGNOR-217920 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr896 | dephosphorylation up-regulates → | IRS1 | 7515062 | SIGNOR-27028 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr989 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-235979 |
| PRKCZ | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 15069075 | SIGNOR-236760 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 15306821 | SIGNOR-127908 |
| PRKCZ | phosphorylation up-regulates → | IRS1 PSer323 | phosphorylation down-regulates ⊣ | IRS1 | 15069075 | SIGNOR-123738 |
| CSNK2A1 | phosphorylation up-regulates → | IRS1 PThr88 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-250911 |
| SIK2 | phosphorylation up-regulates → | IRS1 PSer794 | phosphorylation down-regulates ⊣ | IRS1 | 12624099 | SIGNOR-99059 |
| CSNK2A1 | phosphorylation up-regulates → | IRS1 PSer24 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-250907 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr941 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157754 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr896 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157750 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer531 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251297 |
| PRKCQ | phosphorylation up-regulates → | IRS1 PSer1101 | phosphorylation down-regulates ⊣ | IRS1 | 15364919 | SIGNOR-260906 |
| MEK1/2 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 11160134 | SIGNOR-244784 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236741 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr1179 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157730 |
| MAPK3 | phosphorylation up-regulates → | IRS1 PSer616 | phosphorylation down-regulates ⊣ | IRS1 | 15001544 | SIGNOR-123177 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251292 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106574 |
| PRKACA | phosphorylation up-regulates → | IRS1 PSer1222 | phosphorylation down-regulates ⊣ | IRS1 | 17360977 | SIGNOR-236729 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr612 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157742 |
| PRKCD | phosphorylation up-regulates → | IRS1 PSer323 | phosphorylation down-regulates ⊣ | IRS1 | 15069075 | SIGNOR-123734 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr465 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157738 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer274 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251291 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106570 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer268 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251288 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr896 | dephosphorylation up-regulates → | IRS1 | 10660596 | SIGNOR-74860 |
| PRKCD | phosphorylation up-regulates → | IRS1 PSer616 | phosphorylation down-regulates ⊣ | IRS1 | 15143153 | SIGNOR-124737 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251293 |
| MAPK9 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118881 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr1179 | dephosphorylation up-regulates → | IRS1 | 10660596 | SIGNOR-74856 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer636 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-96948 |
| MAP2K1 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 11160134 | SIGNOR-236611 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer270 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251289 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer527 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251296 |
| SIK2 | phosphorylation up-regulates → | IRS1 PSer794 | phosphorylation down-regulates ⊣ | IRS1 | 24841198 | SIGNOR-265745 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr612 | phosphorylation up-regulates → | IRS1 | 11416002 | SIGNOR-235971 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation up-regulates → | IRS1 | 11416002 | SIGNOR-236709 |
| CSNK2B | phosphorylation up-regulates → | IRS1 PThr88 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-251076 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer345 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251295 |
| PRKCD | phosphorylation up-regulates → | IRS1 PSer1101 | phosphorylation down-regulates ⊣ | IRS1 | 15364919 | SIGNOR-249267 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr1229 | phosphorylation up-regulates → | IRS1 | 12220227 | SIGNOR-235983 |
| PRKCD | phosphorylation up-regulates → | IRS1 PSer323 | phosphorylation down-regulates ⊣ | IRS1 | 16611834 | SIGNOR-146105 |
| PRKACA | phosphorylation up-regulates → | IRS1 PSer1223 | phosphorylation down-regulates ⊣ | IRS1 | 17360977 | SIGNOR-236603 |
| DYRK1A | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation up-regulates → | IRS1 | 31723029 | SIGNOR-279520 |
| CSNK2A1 | phosphorylation up-regulates → | IRS1 PThr502 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-250906 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr1229 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157734 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer636 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106586 |
| RPS6KB1 | phosphorylation up-regulates → | IRS1 PSer1101 | phosphorylation down-regulates ⊣ | IRS1 | 15306821 | SIGNOR-127904 |
| MTOR | phosphorylation up-regulates → | IRS1 PSer616 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106582 |
| EIF2AK2 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 20685959 | SIGNOR-278310 |
| DYRK1A | phosphorylation up-regulates → | IRS1 PSer616 | phosphorylation up-regulates → | IRS1 | 31723029 | SIGNOR-279521 |
| CSNK2A1 | phosphorylation up-regulates → | IRS1 PSer330 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-250908 |
| MAPK1 | phosphorylation up-regulates → | IRS1 PSer616 | phosphorylation down-regulates ⊣ | IRS1 | 15001544 | SIGNOR-123173 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer616 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-96944 |
| CSNK2B | phosphorylation up-regulates → | IRS1 PThr502 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-251077 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer315 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-96940 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr1229 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236752 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr896 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236745 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KB1 | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-236599 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-279183 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157746 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-235975 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-236591 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236725 |
| JAK1 | phosphorylation → up-regulates activity | IRS1 | SIGNOR-251343 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236713 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251294 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106590 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-27024 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-180532 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251290 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106578 |
| CSNK2B | phosphorylation → unknown | IRS1 | SIGNOR-251074 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-51216 |
| MAPK1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-249407 |
| CSNK2B | phosphorylation → unknown | IRS1 | SIGNOR-251075 |
| PTEN | dephosphorylation → down-regulates activity | IRS1 | SIGNOR-277078 |
| SIK2 | phosphorylation → unknown | IRS1 | SIGNOR-99055 |
| MAPK3 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-249409 |
| PRKACA | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-235675 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236756 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-127203 |
| MAPK9 | phosphorylation down-regulates | IRS1 | SIGNOR-52696 |
| MAPK9 | phosphorylation down-regulates | IRS1 | SIGNOR-118873 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-52700 |
| CSNK2A1 | phosphorylation → unknown | IRS1 | SIGNOR-250910 |
| RPS6KB1 | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-236595 |
| PRKCA | phosphorylation → down-regulates activity | IRS1 | SIGNOR-145398 |
| Gbeta | phosphorylation → down-regulates activity | IRS1 | SIGNOR-269997 |
| MAPK1 | phosphorylation down-regulates | IRS1 | SIGNOR-152418 |
| LTK | phosphorylation → up-regulates | IRS1 | SIGNOR-49531 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157758 |
| RPS6K | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-252787 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-118857 |
| CSNK2B | phosphorylation → unknown | IRS1 | SIGNOR-251072 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-148903 |
| CSNK2A1 | phosphorylation → unknown | IRS1 | SIGNOR-250909 |
| PRKCZ | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-236022 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-96936 |
| CSNK2B | phosphorylation → unknown | IRS1 | SIGNOR-251073 |
| JNK | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-235777 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-118861 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-127912 |
| MAPK9 | phosphorylation down-regulates | IRS1 | SIGNOR-118877 |
| PLK1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-135688 |
| MAP2K7 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-217920 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-27028 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-235979 |
| PRKCZ | phosphorylation → down-regulates activity | IRS1 | SIGNOR-236760 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-127908 |
| PRKCZ | phosphorylation down-regulates | IRS1 | SIGNOR-123738 |
| CSNK2A1 | phosphorylation → unknown | IRS1 | SIGNOR-250911 |
| SIK2 | phosphorylation → unknown | IRS1 | SIGNOR-99059 |
| CSNK2A1 | phosphorylation → unknown | IRS1 | SIGNOR-250907 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157754 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157750 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251297 |
| PRKCQ | phosphorylation → down-regulates activity | IRS1 | SIGNOR-260906 |
| RPS6KA1 | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-175687 |
| MEK1/2 | phosphorylation down-regulates | IRS1 | SIGNOR-244784 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236741 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157730 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-255104 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-175665 |
| MAPK3 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-123177 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251292 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106574 |
| PRKACA | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-236729 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157742 |
| PRKCD | phosphorylation down-regulates | IRS1 | SIGNOR-123734 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157738 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251291 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106570 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251288 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-74860 |
| PTPN13 | dephosphorylation → down-regulates activity | IRS1 | SIGNOR-277053 |
| ERK1/2 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-270132 |
| PRKCD | phosphorylation → down-regulates activity | IRS1 | SIGNOR-124737 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251293 |
| MAPK9 | phosphorylation down-regulates | IRS1 | SIGNOR-118881 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-74856 |
| MAPK8 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-96948 |
| MAP2K1 | phosphorylation down-regulates | IRS1 | SIGNOR-236611 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251289 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251296 |
| SIK2 | phosphorylation → down-regulates quantity | IRS1 | SIGNOR-265745 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-235971 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236709 |
| CSNK2B | phosphorylation → unknown | IRS1 | SIGNOR-251076 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251295 |
| PRKCD | phosphorylation → down-regulates activity | IRS1 | SIGNOR-249267 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-235983 |
| PRKCD | phosphorylation down-regulates | IRS1 | SIGNOR-146105 |
| PRKACA | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-236603 |
| IL4R | phosphorylation → up-regulates | IRS1 | SIGNOR-100768 |
| DYRK1A | phosphorylation → up-regulates quantity | IRS1 | SIGNOR-279520 |
| CSNK2A1 | phosphorylation → unknown | IRS1 | SIGNOR-250906 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157734 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106586 |
| RPS6KB1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-127904 |
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106582 |
| EIF2AK2 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-278310 |
| DYRK1A | phosphorylation → up-regulates quantity | IRS1 | SIGNOR-279521 |
| CSNK2A1 | phosphorylation → unknown | IRS1 | SIGNOR-250908 |
| MAPK1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-123173 |
| MAPK8 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-96944 |
| CSNK2B | phosphorylation → unknown | IRS1 | SIGNOR-251077 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-96940 |
| PTPN1 | dephosphorylation down-regulates | IRS1 | SIGNOR-74852 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236752 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236745 |