Summary

Name IRS1
Full Name Insulin receptor substrate 1
Synonyms IRS-1
Primary ID P35568
Links - -
Type protein
Relations 124
Pathways AMPK Signaling, Insulin Receptor, IGF and Myogenesis, Adipogenesis, Luminal Breast Cancer, MTOR Signaling, mTOR cancer
Function May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.08
Publications: 3 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.58
Publications: 6 Organism: Mus Musculus, Homo Sapiens
Tissue: Ovary, Myotube, Brain
Pathways:MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.22
Publications: 1 Organism: Cricetulus Griseus
+ img/unknown.png phosphorylation IRS1 0.08
Publications: 6 Organism: In Vitro
+ img/unknown.png phosphorylation IRS1 0.08
Publications: 6 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.22
Publications: 10 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:Adipogenesis, Insulin Receptor, Luminal Breast Cancer
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.18
Publications: 9 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.14
Publications: 7 Organism: Rattus Norvegicus, Homo Sapiens
Tissue: Kidney
Pathways:MTOR Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.18
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.08
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.22
Publications: 3 Organism: Homo Sapiens
Tissue: Kidney, Muscle, Skeletal Muscle
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.58
Publications: 3 Organism: Mus Musculus
Pathways:MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation IRS1 0.17
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation IRS1 0.08
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.17
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation IRS1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.67
Publications: 10 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png dephosphorylation IRS1 0.28
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IRS1 0.63
Publications: 11 Organism: Cricetulus Griseus, Homo Sapiens, Rattus Norvegicus
Pathways:Adipogenesis, AMPK Signaling, Insulin Receptor, Luminal Breast Cancer, mTOR cancer, MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.08
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding PI3K 0.14
Publications: 3 Organism: Homo Sapiens, Rattus Norvegicus
Tissue: Lung Cancer Cell, Skeletal Muscle
Pathways:mTOR cancer
+ up-regulates activity img/direct-activation.png binding PIK3CA 0.45
Publications: 1 Organism: Homo Sapiens
Tissue: Lung Cancer Cell
Pathways:AMPK Signaling, Luminal Breast Cancer, mTOR cancer, MTOR Signaling, IGF and Myogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:AMPK Signaling, MTOR Signaling
+ down-regulates img/indirect_inhibition.png IRS1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png IRS1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, AMPK Signaling, Insulin Receptor, mTOR cancer, MTOR Signaling
+ up-regulates activity img/direct-activation.png binding PIK3CB 0.36
Publications: 2 Organism: Mus Musculus
Tissue: Muscle
Pathways:Adipogenesis, Insulin Receptor
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.48
Publications: 1 Organism: Rattus Norvegicus
Tissue: Skeletal Muscle
Pathways:MTOR Signaling, IGF and Myogenesis
+ up-regulates img/indirect-activation.png IRS1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png IRS1 0.14
Publications: 1 Organism: Rattus Norvegicus
Tissue: Kidney
Pathways:Adipogenesis, AMPK Signaling, Insulin Receptor, mTOR cancer, MTOR Signaling
+ down-regulates activity img/indirect_inhibition.png IRS1 0.48
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Luminal Breast Cancer, mTOR cancer, MTOR Signaling, IGF and Myogenesis
+ down-regulates activity img/indirect_inhibition.png IRS1 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:mTOR cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png dephosphorylation IRS1 0.08
Publications: 1 Organism: In Vitro
Pathways:Insulin Receptor
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding IRS1 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/indirect_inhibition.png IRS1 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png phosphorylation IRS1 0.08
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding GRB2 0.60
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Insulin Receptor, Luminal Breast Cancer
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.32
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Lung, Smooth Muscle