| + |
PRKACA | down-regulates quantity by destabilization 
phosphorylation
|
IRS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235675 |
Ser1100 |
QGCRRRHsSETFSST |
Homo sapiens |
|
| pmid |
sentence |
| 17360977 |
Tyrosine phosphorylation of IRS-1 initiates insulin signaling, whereas serine/threonine phosphorylation alters the ability of IRS-1 to transduce the insulin signalInsulin increased the phosphorylation of Ser312, Ser616, Ser636, Ser892, Ser1101, and Ser1223 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236729 |
Ser1222 |
ESSSTRRsSEDLSAY |
Homo sapiens |
|
| pmid |
sentence |
| 17360977 |
Tyrosine phosphorylation of IRS-1 initiates insulin signaling, whereas serine/threonine phosphorylation alters the ability of IRS-1 to transduce the insulin signalInsulin increased the phosphorylation of Ser312, Ser616, Ser636, Ser892, Ser1101, and Ser1223 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236603 |
Ser1223 |
SSSTRRSsEDLSAYA |
Homo sapiens |
|
| pmid |
sentence |
| 17360977 |
Tyrosine phosphorylation of IRS-1 initiates insulin signaling, whereas serine/threonine phosphorylation alters the ability of IRS-1 to transduce the insulin signalInsulin increased the phosphorylation of Ser312, Ser616, Ser636, Ser892, Ser1101, and Ser1223 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
RPS6KB1 | down-regulates activity
phosphorylation
|
IRS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127904 |
Ser1101 |
GCRRRHSsETFSSTP |
Mus musculus |
|
| pmid |
sentence |
| 15306821 |
Nevertheless, s6k1-deficient mice remain sensitive to insulin owing to the apparent loss of a negative feedback loop from s6k1 to insulin receptor substrate 1 (irs1), which blunts s307 and s636/s639 phosphorylation; thus under conditions of nutrient satiation s6k1 negatively regulates insulin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51216 |
Ser270 |
EFRPRSKsQSSSNCS |
Homo sapiens |
|
| pmid |
sentence |
| 9312143 |
Turnover of the active fraction of irs1 involves raptor-mtor- and s6k1-dependent serine phosphorylation in cell culture models of tuberous sclerosiss6k1 phosphorylates irs1 in vitro on multiple residues showing strong preference for rxrxxs/t over s/t,p sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127908 |
Ser307 |
TRRSRTEsITATSPA |
Mus musculus |
|
| pmid |
sentence |
| 15306821 |
Nevertheless, s6k1-deficient mice remain sensitive to insulin owing to the apparent loss of a negative feedback loop from s6k1 to insulin receptor substrate 1 (irs1), which blunts s307 and s636/s639 phosphorylation; thus under conditions of nutrient satiation s6k1 negatively regulatesinsulin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148903 |
Ser527 |
RFRKRTHsAGTSPTI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16914728 |
Turnover of the active fraction of irs1 involves raptor-mtor- and s6k1-dependent serine phosphorylation in cell culture models of tuberous sclerosiss6k1 phosphorylates irs1 in vitro on multiple residues showing strong preference for rxrxxs/t over s/t,p sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127912 |
Ser636 |
SGDYMPMsPKSVSAP |
Mus musculus |
|
| pmid |
sentence |
| 15306821 |
Nevertheless, s6k1-deficient mice remain sensitive to insulin owing to the apparent loss of a negative feedback loop from s6k1 to insulin receptor substrate 1 (irs1), which blunts s307 and s636/s639 phosphorylation; thus under conditions of nutrient satiation s6k1 negatively regulatesinsulin. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127203 |
Ser639 |
YMPMSPKsVSAPQQI |
Mus musculus |
|
| pmid |
sentence |
| 15306821 |
Nevertheless, s6k1-deficient mice remain sensitive to insulin owing to the apparent loss of a negative feedback loop from s6k1 to insulin receptor substrate 1 (irs1), which blunts s307 and s636/s639 phosphorylation; thus under conditions of nutrient satiation s6k1 negatively regulatesinsulin. |
|
| Publications: |
6 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Ovary, Myotube, Brain |
| Pathways: | Insulin Signaling, MTOR Signaling |
| + |
PRKCZ | down-regulates quantity by destabilization
phosphorylation
|
IRS1 |
0.732 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236022 |
Ser1101 |
GCRRRHSsETFSSTP |
Homo sapiens |
|
| pmid |
sentence |
| 17360977 |
Tyrosine phosphorylation of IRS-1 initiates insulin signaling, whereas serine/threonine phosphorylation alters the ability of IRS-1 to transduce the insulin signalInsulin increased the phosphorylation of Ser312, Ser616, Ser636, Ser892, Ser1101, and Ser1223 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
PRKCD | down-regulates activity
phosphorylation
|
IRS1 |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249267 |
Ser1101 |
GCRRRHSsETFSSTP |
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 15364919 |
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124737 |
Ser616 |
DDGYMPMsPGVAPVP |
Homo sapiens |
|
| pmid |
sentence |
| 15143153 |
These results indicate that activation of protein kinase c stimulates a kinase which can phosphorylate insulin receptor substrate-1 at serine 612, resulting in an inhibition of insulin signaling in the cell these data suggest that: 1) activation of pkctheta contributes to ikk and jnk activation by ffas;2) ikk and jnk mediate pkctheta signals for irs-1 serine phosphorylation and degradation; ser-302 phosphorylation is dependent on pi 3-kinase/mtor, whereas ser-307 depends on c-jun nh2-terminal kinase to inhibit irs1 tyrosine phosphorylation. Ser-636 is located around the pi 3-kinase binding site and, therefore, thought to inhibit pi 3-kinase signaling. |
|
| Publications: |
2 |
Organism: |
Cricetulus Griseus, Homo Sapiens |
| + |
PRKCQ | down-regulates activity
phosphorylation
|
IRS1 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260906 |
Ser1101 |
GCRRRHSsETFSSTP |
Mus musculus |
|
| pmid |
sentence |
| 15364919 |
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CSNK2B |
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4.0
IRS1
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