| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | IRS1 | Ser24 | GYLRKPKsMHKRFFV | phosphorylation down-regulates activity | 16574739 | SIGNOR-145398 |
| CSNK2B | IRS1 | Ser24 | GYLRKPKsMHKRFFV | phosphorylation unknown | 8349691 | SIGNOR-251072 |
| PLK1 | IRS1 | Ser24 | GYLRKPKsMHKRFFV | phosphorylation down-regulates activity | 15849359 | SIGNOR-135688 |
| CSNK2A1 | IRS1 | Ser24 | GYLRKPKsMHKRFFV | phosphorylation unknown | 8349691 | SIGNOR-250907 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | IRS1 PSer24 | phosphorylation down-regulates ⊣ | IRS1 | 16574739 | SIGNOR-145398 |
| CSNK2B | phosphorylation up-regulates → | IRS1 PSer24 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-251072 |
| PLK1 | phosphorylation up-regulates → | IRS1 PSer24 | phosphorylation down-regulates ⊣ | IRS1 | 15849359 | SIGNOR-135688 |
| CSNK2A1 | phosphorylation up-regulates → | IRS1 PSer24 | phosphorylation down-regulates ⊣ | IRS1 | 8349691 | SIGNOR-250907 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → down-regulates activity | IRS1 | SIGNOR-145398 |
| CSNK2B | phosphorylation → unknown | IRS1 | SIGNOR-251072 |
| PLK1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-135688 |
| CSNK2A1 | phosphorylation → unknown | IRS1 | SIGNOR-250907 |
