| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | dephosphorylation down-regulates | 10660596 | SIGNOR-74860 |
| INSR | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | phosphorylation up-regulates activity | 7651388 | SIGNOR-236745 |
| INSR | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | phosphorylation up-regulates activity | 12220227 | SIGNOR-236725 |
| PTPN11 | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | dephosphorylation down-regulates | 7515062 | SIGNOR-27028 |
| IGF1R | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | phosphorylation up-regulates | 17827393 | SIGNOR-157750 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr896 | dephosphorylation up-regulates → | IRS1 | 10660596 | SIGNOR-74860 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr896 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236745 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr896 | phosphorylation up-regulates → | IRS1 | 12220227 | SIGNOR-236725 |
| PTPN11 | dephosphorylation down-regulates ⊣ | IRS1 PTyr896 | dephosphorylation up-regulates → | IRS1 | 7515062 | SIGNOR-27028 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr896 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157750 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-74860 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236745 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236725 |
| PTPN11 | dephosphorylation down-regulates | IRS1 | SIGNOR-27028 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157750 |
