Entity Details

Name IKBKB_Ser527
ID P35568
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
IKBKBIRS1Ser527RFRKRTHsAGTSPTIphosphorylation
down-regulates activity		12351658SIGNOR-251296
RPS6KB1IRS1Ser527RFRKRTHsAGTSPTIphosphorylation
down-regulates quantity by destabilization		18498745SIGNOR-236595
RPS6KB1IRS1Ser527RFRKRTHsAGTSPTIphosphorylation
down-regulates activity		16914728SIGNOR-148903
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
IKBKBphosphorylation
up-regulates
→
IRS1
PSer527		phosphorylation
down-regulates
⊣		IRS112351658SIGNOR-251296
RPS6KB1phosphorylation
up-regulates
→
IRS1
PSer527		phosphorylation
down-regulates
⊣		IRS118498745SIGNOR-236595
RPS6KB1phosphorylation
up-regulates
→
IRS1
PSer527		phosphorylation
down-regulates
⊣		IRS116914728SIGNOR-148903
Regulator Mechanism/Effect Target SIGNOR-ID
IKBKBphosphorylation
→
down-regulates activity 		IRS1SIGNOR-251296
RPS6KB1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		IRS1SIGNOR-236595
RPS6KB1phosphorylation
→
down-regulates activity 		IRS1SIGNOR-148903