Entity Details

Name IRS1_Ser616
ID P35568
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKCDIRS1Ser616DDGYMPMsPGVAPVPphosphorylation
down-regulates activity		15143153SIGNOR-124737
MAPK8IRS1Ser616DDGYMPMsPGVAPVPphosphorylation
down-regulates activity		12510059SIGNOR-96944
DYRK1AIRS1Ser616DDGYMPMsPGVAPVPphosphorylation
up-regulates quantity		31723029SIGNOR-279521
MTORIRS1Ser616DDGYMPMsPGVAPVPphosphorylation
down-regulates activity		11287630SIGNOR-106582
MAPK3IRS1Ser616DDGYMPMsPGVAPVPphosphorylation
down-regulates activity		15001544SIGNOR-123177
MAPK1IRS1Ser616DDGYMPMsPGVAPVPphosphorylation
down-regulates activity		15001544SIGNOR-123173
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKCDphosphorylation
up-regulates
→
IRS1
PSer616		phosphorylation
down-regulates
⊣		IRS115143153SIGNOR-124737
MAPK8phosphorylation
up-regulates
→
IRS1
PSer616		phosphorylation
down-regulates
⊣		IRS112510059SIGNOR-96944
DYRK1Aphosphorylation
up-regulates
→
IRS1
PSer616		phosphorylation
up-regulates
→		IRS131723029SIGNOR-279521
MTORphosphorylation
up-regulates
→
IRS1
PSer616		phosphorylation
down-regulates
⊣		IRS111287630SIGNOR-106582
MAPK3phosphorylation
up-regulates
→
IRS1
PSer616		phosphorylation
down-regulates
⊣		IRS115001544SIGNOR-123177
MAPK1phosphorylation
up-regulates
→
IRS1
PSer616		phosphorylation
down-regulates
⊣		IRS115001544SIGNOR-123173
Regulator Mechanism/Effect Target SIGNOR-ID
PRKCDphosphorylation
→
down-regulates activity 		IRS1SIGNOR-124737
MAPK8phosphorylation
→
down-regulates activity 		IRS1SIGNOR-96944
DYRK1Aphosphorylation
→
up-regulates quantity 		IRS1SIGNOR-279521
MTORphosphorylation
→
down-regulates activity 		IRS1SIGNOR-106582
MAPK3phosphorylation
→
down-regulates activity 		IRS1SIGNOR-123177
MAPK1phosphorylation
→
down-regulates activity 		IRS1SIGNOR-123173