| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation down-regulates | 14579029 | SIGNOR-118877 |
| INSR | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation up-regulates activity | 7651388 | SIGNOR-236741 |
| INSR | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation up-regulates activity | 11416002 | SIGNOR-236709 |
| IGF1R | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation up-regulates | 17827393 | SIGNOR-157746 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation down-regulates ⊣ | IRS1 | 14579029 | SIGNOR-118877 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236741 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation up-regulates → | IRS1 | 11416002 | SIGNOR-236709 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157746 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK9 | phosphorylation down-regulates | IRS1 | SIGNOR-118877 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236741 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236709 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157746 |
