| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 11287630 | SIGNOR-106574 |
| IKBKB | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 12351658 | SIGNOR-251293 |
| DYRK1A | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation up-regulates quantity | 31723029 | SIGNOR-279520 |
| EIF2AK2 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 20685959 | SIGNOR-278310 |
| MAPK8 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates quantity by destabilization | 12510059 | SIGNOR-236591 |
| MAPK8 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates | 18728222 | SIGNOR-180532 |
| MAPK1 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates | 17242212 | SIGNOR-152418 |
| JNK | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates quantity by destabilization | 12510059 | SIGNOR-235777 |
| MAP2K7 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 17360977 | SIGNOR-217920 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 11287630 | SIGNOR-106574 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251293 |
| DYRK1A | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation up-regulates → | IRS1 | 31723029 | SIGNOR-279520 |
| EIF2AK2 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 20685959 | SIGNOR-278310 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-236591 |
| MAPK8 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 18728222 | SIGNOR-180532 |
| MAPK1 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 17242212 | SIGNOR-152418 |
| JNK | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 12510059 | SIGNOR-235777 |
| MAP2K7 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 17360977 | SIGNOR-217920 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → down-regulates activity | IRS1 | SIGNOR-106574 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251293 |
| DYRK1A | phosphorylation → up-regulates quantity | IRS1 | SIGNOR-279520 |
| EIF2AK2 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-278310 |
| MAPK8 | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-236591 |
| MAPK8 | phosphorylation down-regulates | IRS1 | SIGNOR-180532 |
| MAPK1 | phosphorylation down-regulates | IRS1 | SIGNOR-152418 |
| JNK | phosphorylation down-regulates quantity by destabilization | IRS1 | SIGNOR-235777 |
| MAP2K7 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-217920 |
